Zobrazeno 1 - 10
of 23
pro vyhledávání: '"John O. Onukwufor"'
Autor:
John O. Onukwufor, Collins Kamunde
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 289, Iss , Pp 117450- (2025)
Fish in their natural environments possess elaborate mechanisms that regulate physiological function to mitigate the adverse effects of multiple environmental stressors such as temperature, metals, and hypoxia. We investigated how warm acclimation af
Externí odkaz:
https://doaj.org/article/aabe80fca2ed4748ae95539dd6d29046
Autor:
John O. Onukwufor, M. Arsalan Farooqi, Anežka Vodičková, Shon A. Koren, Aksana Baldzizhar, Brandon J. Berry, Gisela Beutner, George A. Porter, Vsevolod Belousov, Alan Grossfield, Andrew P. Wojtovich
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Mitochondria regulate diverse cellular signalling processes in addition to producing energy. Here, the authors show a mitochondrial redox switch that, when activated, helps nematode worms sense conditions of low environmental oxygen.
Externí odkaz:
https://doaj.org/article/0ca5eb3f762f416595118bd779d947f4
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 692 (2022)
Alzheimer’s disease (AD) is a devastating progressive neurodegenerative disease characterized by neuronal dysfunction, and decreased memory and cognitive function. Iron is critical for neuronal activity, neurotransmitter biosynthesis, and energy ho
Externí odkaz:
https://doaj.org/article/0a221a7d6d5349e18589389d0617efc8
Publikováno v:
Antioxidants, Vol 8, Iss 8, p 285 (2019)
Mitochondrial reactive oxygen species (ROS) can be either detrimental or beneficial depending on the amount, duration, and location of their production. Mitochondrial complex I is a component of the electron transport chain and transfers electrons fr
Externí odkaz:
https://doaj.org/article/8f0a9baa8ccb43b38bf82c2827c4aca9
In nature, mosshead sculpins (Clinocottus globiceps) are challenged by fluctuations in temperature and oxygen levels in their environment. However, it is unclear how mosshead sculpins modulate the permeability of their branchial epithelia to water an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c54ff8d88db28f6bf6f861db5fa6a8e
https://doi.org/10.21203/rs.3.rs-2834006/v1
https://doi.org/10.21203/rs.3.rs-2834006/v1
Autor:
Aditi H Chaubey, Savannah E Sojka, John O Onukwufor, Meredith J Ezak, Matthew D Vandermeulen, Alexander Bowitch, Anežka Vodičková, Andrew P Wojtovich, Denise M Ferkey
Publikováno v:
Genetics. 223
Organisms rely on chemical cues in their environment to indicate the presence or absence of food, reproductive partners, predators, or other harmful stimuli. In the nematode Caenorhabditis elegans, the bilaterally symmetric pair of ASH sensory neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd5aa142f70f86d2bda8f8ff9ee23ac1
https://doi.org/10.1093/genetics/iyad017
https://doi.org/10.1093/genetics/iyad017
Autor:
John O. Onukwufor, Chris M. Wood
Publikováno v:
Zebrafish. 17:400-411
The traditional thesis of the osmorespiratory compromise is that low branchial water and ion permeability would be traded off for increased O2 permeability at times of elevated O2 demand. However, ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e82b1eb012e002ebf99063ac94b5ab7
https://doi.org/10.1089/zeb.2020.1947
https://doi.org/10.1089/zeb.2020.1947
Autor:
John O. Onukwufor, Chris M. Wood
Publikováno v:
Journal of Comparative Physiology B. 190:205-217
Our understanding is limited on how fish adjust the effective permeability of their branchial epithelium to ions and water while altering O2 uptake rate (MO2) with acute and chronic changes in temperature. We investigated the effects of acclimation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5af80ad42cee9ffd0a09a89e44057aa3
https://doi.org/10.1007/s00360-020-01259-4
https://doi.org/10.1007/s00360-020-01259-4
Autor:
John O. Onukwufor, M. Arsalan Farooqi, Anežka Vodičková, Shon A. Koren, Aksana Baldzizhar, Brandon J. Berry, Gisela Beutner, George A. Porter, Vsevolod Belousov, Alan Grossfield, Andrew P. Wojtovich
Publikováno v:
Nature communications. 13(1)
C. elegans react to metabolic distress caused by mismatches in oxygen and energy status via distinct behavioral responses. At the molecular level, these responses are coordinated by under-characterized, redox-sensitive processes, thought to initiate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea6f7edd810d6ae395715c31a92e362
https://pubmed.ncbi.nlm.nih.gov/35504873
https://pubmed.ncbi.nlm.nih.gov/35504873
Publikováno v:
Comparative biochemistry and physiology. Part A, Molecularintegrative physiology. 250
The osmorespiratory compromise hypothesis posits that respiratory epithelial characteristics and physiological regulatory mechanisms which promote gas permeability also increase permeability to ions and water. The hypothesis therefore predicts that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9115970da9a6af8760e953d9bfa72e73
https://pubmed.ncbi.nlm.nih.gov/32763468
https://pubmed.ncbi.nlm.nih.gov/32763468