Zobrazeno 1 - 10
of 13
pro vyhledávání: '"John O. Konz"'
Autor:
Rahnuma Wahid, Laina Mercer, Chris Gast, Tirza De Leon, Xavier Sáez-Llorens, Alan Fix, Andrew Macadam, Laura Stephens, Konstantin Chumakov, Saskia L. Smits, Marta Murreddu, Jennifer L. Konopka-Anstadt, M. Steven Oberste, Cara C. Burns, Raul Andino, Novilia Sjafri Bachtiar, Erman Tritama, Ananda S. Bandyopadhyay, Gabriela Aguirre, Ricardo Rüttimann, John O. Konz
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Novel oral poliovirus vaccine type 2 (nOPV2) is being developed to reduce the rare occurrence of disease and outbreaks associated with the genetic instability of the Sabin vaccine strains. Children aged 1 to 5 years were enrolled in two rela
Externí odkaz:
https://doaj.org/article/a5bc437be7da4f459a47f98cae18af83
Autor:
John O. Konz, Tim Schofield, Sarah Carlyle, Rahnuma Wahid, Azeem Ansari, Jeroen R.P.M. Strating, Ming Te Yeh, Hasmik Manukyan, Saskia L. Smits, Erman Tritama, Latri Rahmah, Dori Ugiyadi, Raul Andino, Majid Laassri, Konstantin Chumakov, Andrew Macadam
Publikováno v:
Vaccine: X, Vol 8, Iss , Pp 100102- (2021)
A novel, genetically-stabilized type 2 oral polio vaccine (nOPV2), developed to assist in the global polio eradication program, was recently the first-ever vaccine granted Emergency Use Listing by the WHO. Lot release tests for this vaccine included
Externí odkaz:
https://doaj.org/article/7805eacc4a144c3289cf7f764ff52931
Autor:
Rahnuma Wahid, Laina D Mercer, Tirza De Leon, Rodrigo DeAntonio, Xavier Sáez-Llorens, Andrew Macadam, Konstantin Chumakov, Jeroen Strating, Björn Koel, Jennifer L Konopka-Anstadt, M Steven Oberste, Cara C Burns, Raul Andino, Erman Tritama, Ananda S Bandyopadhyay, Gabriela Aguirre, Ricardo Rüttimann, Chris Gast, John O Konz
Publikováno v:
The Lancet Microbe. 3:e912-e921
Sabin strains used in oral poliovirus vaccines (OPV) can revert to virulence and, in rare instances, cause disease or generate vaccine-derived strains leading to outbreaks in areas of low immunisation coverage. A novel OPV2 (nOPV2) was designed to st
Autor:
Sangeetha L. Sagar, John O. Konz, Aaron R. Goerke, Michael E Laska, Rebecca C Livingood, Andrew J. Bett
Publikováno v:
Human Gene Therapy. 16:1346-1353
Recombinant adenoviruses continue to be a leading vector choice for gene transfer applications, with growing interest in the use of less prevalent serotypes, and of chimeras. As a result, the development of scaleable purification processes for altern
Publikováno v:
Biotechnology Progress. 14:393-409
Efforts to increase cell growth and protein yields need to be complemented by the maintenance of the quality of the protein produced. Elevated oxygen pressure or rapid increases in oxygen content can cause oxidative stress within the cells, leading t
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 434
Adenovirus vectors currently are being evaluated in gene delivery studies ranging from prophylactic vaccination to therapeutic gene therapy. The quantity of purified virus required for these studies necessitate that purification methods must shift fr
Publikováno v:
Gene Therapy Protocols ISBN: 9781603272476
Adenovirus vectors currently are being evaluated in gene delivery studies ranging from prophylactic vaccination to therapeutic gene therapy. The quantity of purified virus required for these studies necessitate that purification methods must shift fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9724e47063365e8b742842ed08e16ac
https://doi.org/10.1007/978-1-60327-248-3_2
https://doi.org/10.1007/978-1-60327-248-3_2
Publikováno v:
Biotechnology progress. 22(2)
Plasmid DNA purification development has been driven by the increased need for large quantities of highly purified, sterile plasmid DNA for clinical studies. Detailed characterization and development of the terminal sterile filtration process step is
Publikováno v:
Biotechnology progress. 21(4)
As the field of plasmid DNA-based vaccines and therapeutics matures, improved methods for impurity clearance monitoring are increasingly valuable for process development and scale-up. Residual host-cell RNA is a major impurity in current large-scale
Publikováno v:
Biotechnology progress. 21(2)
The clearance of host cell DNA is a critical goal for purification process development for recombinant Ad5 (rAd5) based vaccines and gene therapy products. We have evaluated the clearance of DNA by a rAd5 purification process utilizing nuclease diges