Zobrazeno 1 - 10
of 184
pro vyhledávání: '"John O, Trent"'
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
DNA G-quadruplexes (G4s) are now widely accepted as viable targets in the pursuit of anticancer therapeutics. To date, few small molecules have been identified that exhibit selectivity for G4s over alternative forms of DNA, such as the ubiquitous dup
Externí odkaz:
https://doaj.org/article/222165cb4c8246be965eb0eccafe0b5a
Autor:
Lynn W DeLeeuw, Robert C Monsen, Vytautas Petrauskas, Robert D Gray, Lina Baranauskiene, Daumantas Matulis, John O Trent, Jonathan B Chaires
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245675 (2021)
The protein POT1 (Protection of Telomeres 1) is an integral part of the shelterin complex that protects the ends of human chromosomes from degradation or end fusions. It is the only component of shelterin that binds single-stranded DNA. We describe h
Externí odkaz:
https://doaj.org/article/d54a95b20059451db626866be17532dd
Publikováno v:
Nucleic Acids Research. 51:1943-1959
Genomic regions with high guanine content can fold into non-B form DNA four-stranded structures known as G-quadruplexes (G4s). Extensive in vivo investigations have revealed that promoter G4s are transcriptional regulators. Little structural informat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d409dfd27b7ed4585cb38cf1dbb4cb8
https://doi.org/10.1093/nar/gkad014
https://doi.org/10.1093/nar/gkad014
Autor:
John D. Belcher, Ping Zhang, Julia Nguyen, Zachary M. Kiser, Karl A. Nath, Jianjun Hu, John O. Trent, Gregory M. Vercellotti
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Myeloid differentiation factor-2 (MD-2) binds lipopolysaccharide (LPS) and initiates toll-like receptor-4 (TLR4) pro-inflammatory signaling. Heme also activates TLR4 signaling, but it is unknown if heme interacts with MD-2. Therefore, we examined MD-
Externí odkaz:
https://doaj.org/article/99eb18fc3b6b43cfa494c8c1667c1c26
Publikováno v:
Accounts of Chemical Research. 55:3242-3252
ConspectusG-quadruplexes (G4s) are distinctive four-stranded DNA or RNA structures found within cells that are thought to play functional roles in gene regulation and transcription, translation, recombination, and DNA damage/repair. While G4 structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d59aec458fa4302b2831a98ff83dbd
https://doi.org/10.1021/acs.accounts.2c00519
https://doi.org/10.1021/acs.accounts.2c00519
Supplementary figure 3 from Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic
Autor:
Virna D. Leaner, John O. Trent, Michael J. Birrer, Wei Wei, Dirk Lang, Kate Hadley, Liselotte Angus, Sarah Carden, Erin Strydom, Catherine Stowell, Tamara Stelma, Alicia Chi, Pauline J. van der Watt
Body mass graphs from in vivo studies showing no change in body weight over the treatment time-courses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a0fbe04af14fa266eb8fbe37925cef
https://doi.org/10.1158/1535-7163.22501620.v1
https://doi.org/10.1158/1535-7163.22501620.v1
Autor:
Virna D. Leaner, John O. Trent, Michael J. Birrer, Wei Wei, Dirk Lang, Kate Hadley, Liselotte Angus, Sarah Carden, Erin Strydom, Catherine Stowell, Tamara Stelma, Alicia Chi, Pauline J. van der Watt
IC50 values obtained from INI-43 treatment of cancer, transformed and normal cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5faad515903079a07dbccf8b8423f9b1
https://doi.org/10.1158/1535-7163.22501629.v1
https://doi.org/10.1158/1535-7163.22501629.v1
Autor:
Virna D. Leaner, John O. Trent, Michael J. Birrer, Wei Wei, Dirk Lang, Kate Hadley, Liselotte Angus, Sarah Carden, Erin Strydom, Catherine Stowell, Tamara Stelma, Alicia Chi, Pauline J. van der Watt
Karyopherin beta 1 (Kpnβ1) is a nuclear transport receptor that imports cargoes into the nucleus. Recently, elevated Kpnβ1 expression was found in certain cancers and Kpnβ1 silencing with siRNA was shown to induce cancer cell death. This study aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae6abcb98c5725fed39658f41912007b
https://doi.org/10.1158/1535-7163.c.6536847.v1
https://doi.org/10.1158/1535-7163.c.6536847.v1
Autor:
Virna D. Leaner, John O. Trent, Michael J. Birrer, Wei Wei, Dirk Lang, Kate Hadley, Liselotte Angus, Sarah Carden, Erin Strydom, Catherine Stowell, Tamara Stelma, Alicia Chi, Pauline J. van der Watt
Chemical compounds identified in the in silico screen that display IC50 values of less than 50uM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4005ade69fdf7d2c521b15ee6461b138
https://doi.org/10.1158/1535-7163.22501617
https://doi.org/10.1158/1535-7163.22501617
Supplementary figure 1 from Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic
Autor:
Virna D. Leaner, John O. Trent, Michael J. Birrer, Wei Wei, Dirk Lang, Kate Hadley, Liselotte Angus, Sarah Carden, Erin Strydom, Catherine Stowell, Tamara Stelma, Alicia Chi, Pauline J. van der Watt
Dose-response curves showing cell line responses to INI-43 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a70520e5c0a7430da83031231e3e09d
https://doi.org/10.1158/1535-7163.22501626
https://doi.org/10.1158/1535-7163.22501626