Zobrazeno 1 - 10
of 195
pro vyhledávání: '"John O, Mason"'
Autor:
P. Barrett Paulk, Dala Eloubeidi, Mark Johnson, Thomas Swain, John O. Mason, Christine A. Curcio, Jason N. Crosson
Publikováno v:
BMC Ophthalmology, Vol 22, Iss 1, Pp 1-5 (2022)
Abstract Background The prognosis for patients with macula-off rhegmatogenous retinal detachment (RRD) and concomitant age-related macular degeneration (AMD) is not well known. The purpose of this study is to compare visual outcomes in macula-off RRD
Externí odkaz:
https://doaj.org/article/6d2ff6af04c646ce862a3dc90dfcdfa7
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/5f999fd6fbe94e8abffc53974636f8ff
Autor:
Martine Manuel, Kai Boon Tan, Zrinko Kozic, Michael Molinek, Tiago Sena Marcos, Maizatul Fazilah Abd Razak, Dániel Dobolyi, Ross Dobie, Beth E P Henderson, Neil C Henderson, Wai Kit Chan, Michael I Daw, John O Mason, David J Price
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001563 (2022)
The development of stable specialized cell types in multicellular organisms relies on mechanisms controlling inductive intercellular signals and the competence of cells to respond to such signals. In developing cerebral cortex, progenitors generate o
Externí odkaz:
https://doaj.org/article/e095303f3e8640019b40c0c448f676c2
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-14 (2020)
Abstract Some autism spectrum disorders (ASD) likely arise as a result of abnormalities during early embryonic development of the brain. Studying human embryonic brain development directly is challenging, mainly due to ethical and practical constrain
Externí odkaz:
https://doaj.org/article/4aa70421c284438e9b86fd6c26241e28
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0278147 (2022)
Cerebral organoids show great promise as tools to unravel the complex mechanisms by which the mammalian brain develops during embryogenesis. We generated mouse cerebral organoids harbouring constitutive or conditional mutations in Pax6, which encodes
Externí odkaz:
https://doaj.org/article/b3040076fbb049b7bbbb9ad43dd2e4b4
Autor:
Idoia Quintana-Urzainqui, Zrinko Kozić, Soham Mitra, Tian Tian, Martine Manuel, John O. Mason, David J. Price
Publikováno v:
iScience, Vol 10, Iss , Pp 171-191 (2018)
Summary: Differences in the growth and maturation of diverse forebrain tissues depend on region-specific transcriptional regulation. Individual transcription factors act simultaneously in multiple regions that develop very differently, raising questi
Externí odkaz:
https://doaj.org/article/b8ff80ce75ab4ab7bd30157f0c18bcb8
Autor:
Meredith E. Thomley, Cole N. Gross, Ana Preda-Naumescu, Kelly S. Chen, Thomas Swain, John O. Mason III, Jason N. Crosson
Publikováno v:
Journal of Ophthalmology, Vol 2021 (2021)
The purpose of this study was to assess outcomes in a real-world nonclinical trial setting of antivascular endothelial growth factor (VEGF) injections alone vs. focal laser combined with anti-VEGF injections in patients with branch retinal vein occlu
Externí odkaz:
https://doaj.org/article/62ae342227004180bb4bffdf2eb55f86
Publikováno v:
BMC Neuroscience, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background We studied whether regulation of Cdca7 (Cell division cycle associated 7) expression by transcription factor Pax6 contributes to Pax6’s cellular actions during corticogenesis. The function of Cdca7 in mediating Pax6’s effects
Externí odkaz:
https://doaj.org/article/51469a3dec834b8fa191f2e569cab10e
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The transcription factor Pax6 controls multiple aspects of forebrain development. Conditional deletion of Pax6 in embryonic mouse cortex causes increased proliferation of cortical progenitor cells and a concomitant decrease in neural differentiation.
Externí odkaz:
https://doaj.org/article/75b019f8b8bb4739bcb7c27362b9772f
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Pax6 is a key regulator of the rates of progenitor cell division in cerebral corticogenesis. Previous work has suggested that this action is mediated at least in part by regulation of the cell cycle gene Cdk6, which acts largely on the transition fro
Externí odkaz:
https://doaj.org/article/f1803148e5294bd590128f1882a11d64