Distinct effects of AMPAR subunit depletion on spatial memory

Autor: Ahmed Eltokhi, Ilaria Bertocchi, Andrei Rozov, Vidar Jensen, Thilo Borchardt, Amy Taylor, Catia C. Proenca, John Nick P. Rawlins, David M. Bannerman, Rolf Sprengel

Publikováno v: iScience, Vol 26, Iss 11, Pp 108116- (2023)

Summary: Pharmacological studies established a role for AMPARs in the mammalian forebrain in spatial memory performance. Here we generated global GluA1/3 double knockout mice (Gria1/3−/−) and conditional knockouts lacking GluA1 and GluA3 AMPAR su

Externí odkaz: https://doaj.org/article/3d19046a94f54e098f4d4195cc9ae8b8

Author Correction: Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice

Autor: Ilaria Bertocchi, Ahmed Eltokhi, Andrey Rozov, Vivan Nguyễn Chi, Vidar Jensen, Thorsten Bus, Verena Pawlak, Marta Serafino, Hannah Sonntag, Boyi Yang, Nail Burnashev, Shi-Bin Li, Horst A. Obenhaus, Martin Both, Burkhard Niewoehner, Frank N. Single, Michael Briese, Thomas Boerner, Peter Gass, John Nick P. Rawlins, Georg Köhr, David M. Bannerman, Rolf Sprengel

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)

A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01717-x

Externí odkaz: https://doaj.org/article/1cf4af9fc14a435ebc358f2142fe71c9

Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice

Autor: Vidar Jensen, Nail Burnashev, Marta Serafino, Ahmed Eltokhi, Ilaria Bertocchi, Michael Briese, David M. Bannerman, Peter Gass, Thorsten Bus, Boyi Yang, Burkhard Niewoehner, Frank Nicolai Single, Thomas Boerner, Shi-Bin Li, Georg Köhr, Rolf Sprengel, John Nick P Rawlins, Hannah Sonntag, Andrey Rozov, Horst A. Obenhaus, Vivan Nguyen Chi, Verena Pawlak, Martin Both

Publikováno v: Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-21 (2021)
Communications Biology, Nature Publishing Group, 2021, 4, ⟨10.1038/s42003-020-01538-4⟩
Communications Biology, 2021, 4, ⟨10.1038/s42003-020-01538-4⟩

The NMDA receptor-mediated Ca2+ signaling during simultaneous pre- and postsynaptic activity is critically involved in synaptic plasticity and thus has a key role in the nervous system. In GRIN2-variant patients alterations of this coincidence detect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f3e8c2439e6ad74ae4bd47bbdd11b6
https://hdl.handle.net/11250/2979432