Zobrazeno 1 - 10
of 184
pro vyhledávání: '"John N. Whitaker"'
Publikováno v:
Journal of Clinical Neuromuscular Disease. 18:21-27
Objectives We conducted a retrospective study analyzing the clinical features, laboratory findings, demographics, and long-term prognoses of patients with juvenile inflammatory myopathies to determine possible predictors indicating the use of aggress
Autor:
Anthony P. Nicholas, Kiran Gupta, Carey McInnis, Joshua D. Echols, Jeffrey L. King, Thiagarajan Sambandam, John N. Whitaker
Publikováno v:
The Journal of Comparative Neurology. 459:251-266
By using hybridoma technology, an IgM monoclonal antibody (F95) against multiple citrullinated synthetic and natural peptides was recently developed and used to stain immunohistochemically subsets of astrocytes and myelin basic protein (MBP) from sel
Autor:
John N. Whitaker, Anthony P. Nicholas
Publikováno v:
Glia. 37:328-336
Using hybridoma technology, an IgM monoclonal antibody (mAb), designated as F95, was developed against a deca-citrullinated peptide (DCP) consisting of 10 citrulline residues and a carboxyl Gly-Gly-Cys through which DCP was covalently linked to an ac
Publikováno v:
Current Opinion in Neurology. 14:765-769
Compression of cervical spinal cord secondary to cervical spondylosis or disc herniation can result in acute or chronic myelopathy. This may go unnoticed in patients with multiple sclerosis who frequently present with similar symptoms. A high index o
Myelin Antigen-Specific CD8+ T Cells Are Encephalitogenic and Produce Severe Disease in C57BL/6 Mice
Autor:
Di Liu, John N. Whitaker, Zhigang Huang, Deming Sun, Cedric S. Raine, Hartmut Wekerle, Christopher Coleclough
Publikováno v:
The Journal of Immunology. 166:7579-7587
Encephalitogenic T cells that mediate experimental autoimmune encephalomyelitis (EAE) are commonly assumed to be exclusively CD4+, but formal proof is still lacking. In this study, we report that synthetic peptides 35–55 from myelin oligodendrocyte
Autor:
Khurram Bashir, John N. Whitaker
Publikováno v:
Multiple Sclerosis Journal. 6:312-316
Patients presenting with isolated partial cervical myelopathy are at high risk for development of multiple sclerosis (MS), especially if lesions suggestive of demyelination are present on cranial magnetic resonance imaging (MRI). This risk is lower,
Autor:
Ligong Cao, L. R. Tranquill, Hubert Kalbacher, Roland M Martin, John N. Whitaker, Nicholas Ling
Publikováno v:
Multiple Sclerosis Journal. 6:220-225
Myelin basic protein (MBP), a candidate autoantigen in multiple sclerosis (MS), exists in different isoforms and charge isomers generated by differential splicing of exons and by a combination of posttranslational modifications, respectively. These v
Autor:
Mario A. Moscarello, Deming Sun, Ligong Cao, Tony F. Cruz, Samuel K. Ludwin, John N. Whitaker
Publikováno v:
Journal of Neuroimmunology. 108:103-111
Experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), is useful for preclinical testing for agents to be considered for treatment for this human demyelinating disease. Microtubules in lymphocytes play an importan
Autor:
John N. Whitaker, P. Gjörstrup, Fred D. Lublin, A. Linde, Jerry S. Wolinsky, H. C. Sullivan, Ponnada A. Narayana, John H. Noseworthy
Publikováno v:
Neurology. 54:1734-1741
Objective: To determine the safety and efficacy of roquinimex (linomide) in the management of relapsing-remitting and secondary progressive MS as monitored by MRI. Background: Preclinical studies and several short term randomized trials of linomide s
Publikováno v:
Archives of Biochemistry and Biophysics. 377:9-21
Multiple sclerosis (MS) is clinically heterogeneous and has an uncertain natural history. A high priority for more effective treatment of MS is an objective and feasible laboratory test for predicting the disease's course and response to treatments.