Zobrazeno 1 - 10
of 26
pro vyhledávání: '"John N. Mariani"'
Autor:
John N. Mariani, Benjamin Mansky, Pernille M. Madsen, Dennis Salinas, Deniz Kesmen, Nguyen P. T. Huynh, Nicholas J. Kuypers, Erin R. Kesel, Janna Bates, Casey Payne, Devin Chandler-Militello, Abdellatif Benraiss, Steven A. Goldman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Human glial progenitor cells (hGPCs) exhibit diminished expansion competence with age, as well as after recurrent demyelination. Using RNA-sequencing to compare the gene expression of fetal and adult hGPCs, we identify age-related changes in
Externí odkaz:
https://doaj.org/article/5d6bbb20559247ef91df3bdc2e5860bf
Autor:
Masaki Takasugi, Naoko Ohtani, Kazuaki Takemura, Stephan Emmrich, Frances T. Zakusilo, Yuya Yoshida, Nobuyuki Kutsukake, John N. Mariani, Martha S. Windrem, Devin Chandler-Militello, Steven A. Goldman, Junko Satoh, Shinji Ito, Andrei Seluanov, Vera Gorbunova
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113130- (2023)
Summary: The naked mole rat (NMR) is the longest-lived rodent, resistant to multiple age-related diseases including neurodegeneration. However, the mechanisms underlying the NMR’s resistance to neurodegenerative diseases remain elusive. Here, we is
Externí odkaz:
https://doaj.org/article/04f80f73b8014e2e83d91863b9a4d47c
Autor:
Martha S. Windrem, Steven J. Schanz, Lisa Zou, Devin Chandler-Militello, Nicholas J. Kuypers, Maiken Nedergaard, Yuan Lu, John N. Mariani, Steven A. Goldman
Publikováno v:
Cell Reports, Vol 31, Iss 7, Pp - (2020)
Summary: Neonatally transplanted human glial progenitor cells (hGPCs) can myelinate the brains of myelin-deficient shiverer mice, rescuing their phenotype and survival. Yet, it has been unclear whether implanted hGPCs are similarly able to remyelinat
Externí odkaz:
https://doaj.org/article/e1de419a98cd45748915eb59ead661be
Autor:
Maria Joana Osorio, John N. Mariani, Lisa Zou, Steven J. Schanz, Kate Heffernan, Adam Cornwell, Steven A. Goldman
Publikováno v:
Osorio, M J, Mariani, J N, Zou, L, Schanz, S J, Heffernan, K, Cornwell, A & Goldman, S A 2023, ' Glial progenitor cells of the adult human white and grey matter are contextually distinct ', Glia, vol. 71, no. 3, pp. 524-540 . https://doi.org/10.1002/glia.24291
Genomic analyses have revealed heterogeneity among glial progenitor cells (GPCs), but the compartment selectivity of human GPCs (hGPCs) is unclear. Here, we asked if GPCs of human grey and white brain matter are distinct in their architecture and ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0441d4589702f469309819dcba70240
https://doi.org/10.1002/glia.24291
https://doi.org/10.1002/glia.24291
Autor:
Maria Joana Osorio, John N. Mariani, Lisa Zou, Steven J. Schanz, Kate Heffernan, Adam Cornwell, Steven A. Goldman
Publikováno v:
Glia. 71
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e15be3e79c59a7fbf05fb01222d3d91a
https://doi.org/10.1002/glia.24204
https://doi.org/10.1002/glia.24204
Autor:
Abdellatif Benraiss, John N. Mariani, Ashley Tate, Pernille M. Madsen, Kathleen M. Clark, Kevin A. Welle, Renee Solly, Laetitia Capellano, Karen Bentley, Devin Chandler-Militello, Steven A. Goldman
Publikováno v:
Benraiss, A, Mariani, J N, Tate, A, Madsen, P M, Clark, K M, Welle, K A, Solly, R, Capellano, L, Bentley, K, Chandler-Militello, D & Goldman, S A 2022, ' A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice ', Cell Reports, vol. 40, no. 9, 111291 . https://doi.org/10.1016/j.celrep.2022.111291
Huntington’s disease (HD) is characterized by defective oligodendroglial differentiation and white matter disease. Here, we investigate the role of oligodendrocyte progenitor cell (OPC) dysfunction in adult myelin maintenance in HD. We first note a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbe5e536dd7841c848b9b470d4e5249
https://pubmed.ncbi.nlm.nih.gov/36044851
https://pubmed.ncbi.nlm.nih.gov/36044851
Autor:
Martha S. Windrem, Mikhail Osipovitch, Devin Chandler-Militello, Abdellatif Benraiss, Steven A. Goldman, Carlos Benitez Villanueva, John N. Mariani, Adam Cornwell
Publikováno v:
Benraiss, A, Mariani, J N, Osipovitch, M, Cornwell, A, Windrem, M S, Villanueva, C B, Chandler-Militello, D & Goldman, S A 2021, ' Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease ', Cell Reports, vol. 36, no. 1, 109308 . https://doi.org/10.1016/j.celrep.2021.109308
Glial pathology is a causal contributor to the striatal neuronal dysfunction of Huntington's disease (HD). We investigate mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b206d15dbfad3f84e0ea8f4d27df81c8
https://curis.ku.dk/portal/da/publications/cellintrinsic-glial-pathology-is-conserved-across-human-and-murine-models-of-huntingtons-disease(c3ca9d6a-32a3-4218-8682-ce9366a925d3).html
https://curis.ku.dk/portal/da/publications/cellintrinsic-glial-pathology-is-conserved-across-human-and-murine-models-of-huntingtons-disease(c3ca9d6a-32a3-4218-8682-ce9366a925d3).html
Publikováno v:
Goldman, S A, Mariani, J N & Madsen, P M 2021, ' Glial progenitor cell-based repair of the dysmyelinated brain : Progression to the clinic ', Seminars in Cell and Developmental Biology, vol. 116, pp. 62-70 . https://doi.org/10.1016/j.semcdb.2020.12.004
Semin Cell Dev Biol
Semin Cell Dev Biol
Demyelinating disorders of the central white matter are among the most prevalent and disabling conditions in neurology. Since myelin-producing oligodendrocytes comprise the principal cell type deficient or lost in these conditions, their replacement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfe5556dd2039b055ad6c88ea142728
https://curis.ku.dk/ws/files/334400670/nihms_1708427.pdf
https://curis.ku.dk/ws/files/334400670/nihms_1708427.pdf
Autor:
Erin R. Kesel, Nicholas J. Kuypers, Benjamin Mansky, Steven A. Goldman, Pernille M. Madsen, Nguyen P.T. Huynh, John N. Mariani, Devin Chandler-Militello, Abdellatif Benraiss
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9439179598ffd05a8749e4f44f88afc
https://doi.org/10.2139/ssrn.3950750
https://doi.org/10.2139/ssrn.3950750
Autor:
Devin Chandler-Militello, Steven A. Goldman, Abdellatif Benraiss, John N. Mariani, Laetitia Capellano, Renee Solly, Karen L. de Mesy Bentley, Ashley Tate
Publikováno v:
SSRN Electronic Journal.
Huntington’s disease (HD) is characterized by defective oligodendroglial differentiation and white matter disease. Here, we investigated the role of glial progenitor cell (GPC) dysfunction in adult myelin maintenance in HD. We first noted a progres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e409fcbcfe1390b43912b29a53f80ddd
https://doi.org/10.2139/ssrn.3921284
https://doi.org/10.2139/ssrn.3921284