Zobrazeno 1 - 10
of 38
pro vyhledávání: '"John N. Brewin"'
Autor:
Deborah E. Daniels, Ivan Ferrer-Vicens, Joseph Hawksworth, Tatyana N. Andrienko, Elizabeth M. Finnie, Natalie S. Bretherton, Daniel C. J. Ferguson, A. Sofia. F. Oliveira, Jenn-Yeu A. Szeto, Marieangela C. Wilson, John N. Brewin, Jan Frayne
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract β-thalassemia is a prevalent genetic disorder causing severe anemia due to defective erythropoiesis, with few treatment options. Studying the underlying molecular defects is impeded by paucity of suitable patient material. In this study we
Externí odkaz:
https://doaj.org/article/9939683767224f40b2a842f9297fb596
Autor:
Viola Introini, Alejandro Marin-Menendez, Guilherme Nettesheim, Yen-Chun Lin, Silvia N. Kariuki, Adrian L. Smith, Letitia Jean, John N. Brewin, David C. Rees, Pietro Cicuta, Julian C. Rayner, Bridget S. Penman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Malaria parasites such as Plasmodium falciparum have exerted formidable selective pressures on the human genome. Of the human genetic variants associated with malaria protection, beta thalassaemia (a haemoglobinopathy) was the earliest to be
Externí odkaz:
https://doaj.org/article/e6afa95052a148bb94000f442cc19fc0
Autor:
Amina Nardo-Marino, Thomas H. Braunstein, Jesper Petersen, John N. Brewin, Mathis N. Mottelson, Thomas N. Williams, Jørgen A. L. Kurtzhals, David C. Rees, Andreas Glenthøj
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The spleen plays an important role in the body’s defence against bacterial infections. Measuring splenic function is of interest in multiple conditions, including sickle cell anaemia (SCA), where spleen injury occurs early in life. Unfortunately, t
Externí odkaz:
https://doaj.org/article/079074c556694ff5b1b8766f2f715cee
Autor:
David C.-Y. Lu, Rasiqh Wadud, Anke Hannemann, David C. Rees, John N. Brewin, John Stanley Gibson
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Red cells from patients with sickle cell anaemia (SCA) contain the abnormal haemoglobin HbS. Under hypoxic conditions, HbS polymerises and causes red cell sickling, a rise in intracellular Ca2+ and exposure of phosphatidylserine (PS). These changes m
Externí odkaz:
https://doaj.org/article/ebe75d5e74ca4d73a1ce09566d93a87d
Autor:
John N. Brewin, Helen Rooks, Kate Gardner, Harry Senior, Mrinmayi Morje, Hamel Patel, David Calvet, Pablo Bartolucci, Swee-Lay Thein, Stephan Menzel, David C. Rees
Publikováno v:
Haematologica, Vol 106, Iss 6 (2020)
Externí odkaz:
https://doaj.org/article/c28b2f15c0fa40b79880153968ee1f14
Autor:
Halima Al Balushi, Kobina Dufu, David C. Rees, John N. Brewin, Anke Hannemann, Donna Oksenberg, David C.‐Y. Lu, John S. Gibson
Publikováno v:
Physiological Reports, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Sickle cell anemia (SCA) is one of the commonest severe inherited disorders. Nevertheless, effective treatments remain inadequate and novel ones are avidly sought. A promising advance has been the design of novel compounds which react with h
Externí odkaz:
https://doaj.org/article/9c3d3183d1f64aec9f3a922b887157e1
Autor:
John N. Brewin, Amina Nardo‐Marino, Sara Stuart‐Smith, Sara El Hoss, Anke Hanneman, John Strouboulis, Stephan Menzel, John S. Gibson, David C. Rees
Publikováno v:
American Journal of Hematology. 97:1275-1285
Publikováno v:
Haematologica
Autor:
Amina Nardo‐Marino, Andreas Glenthøj, John N. Brewin, Jesper Petersen, Thomas H. Braunstein, Jørgen A. L. Kurtzhals, Thomas N. Williams, David C. Rees
Publikováno v:
Nardo-Marino, A, Glenthøj, A, Brewin, J N, Petersen, J, Braunstein, T H, Kurtzhals, J A L, Williams, T N & Rees, D C 2022, ' The significance of spleen size in children with sickle cell anemia ', American Journal of Hematology, vol. 97, no. 12, pp. 1520-1528 . https://doi.org/10.1002/ajh.26703
It is well established that splenic dysfunction occurs in early childhood in sickle cell anemia (SCA), although the determinants and consequences of splenic injury are not fully understood. In this study, we examined spleen size and splenic function
Autor:
Amina Nardo-Marino, Andreas Glenthøj, John N. Brewin, Jesper Petersen, Thomas H. Braunstein, Jørgen A.L. Kurtzhals, Thomas N. Williams, David C. Rees
Publikováno v:
Blood. 140:1639-1640