Zobrazeno 1 - 10
of 37
pro vyhledávání: '"John N. Calley"'
Autor:
Steven M. Bray, Jeeyun Lee, Seung Tae Kim, Joon Young Hur, Philip J. Ebert, John N. Calley, Isabella H. Wulur, Thejaswini Gopalappa, Swee Seong Wong, Hui-Rong Qian, Jason C. Ting, Jiangang Liu, Melinda D. Willard, Ruslan D. Novosiadly, Young Suk Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Amit Aggarwal, Hee Cheol Kim, Christoph Reinhard
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Anti-EGFR antibodies are effective in therapies for late-stage colorectal cancer (CRC); however, many tumours are unresponsive or develop resistance. We performed genomic analysis of intrinsic and acquired resistance to anti-EGFR therapy in
Externí odkaz:
https://doaj.org/article/f456fa8deb9947ea89d5b6e8de43eb83
Autor:
Do-Hyun Nam, Christoph Reinhard, Catherine F. Whittington, Jiangang Liu, Jason C. Ting, Amit Aggarwal, Shripad V. Bhagwat, Hye Kyung Hong, Sheng-Bin Peng, Philip J. Ebert, Steven M. Bray, Woo Yong Lee, John N. Calley, Robert A. Wild, Swee Seong Wong, Yong Beom Cho, Song Wu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Metastasis is the primary cause of cancer mortality. The primary tumors of colorectal cancer (CRC) often metastasize to the liver. In this study, we have collected 122 samples from 45 CRC patients. Among them, 32 patients have primary tumors, adjacen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fab650116b630c34dbd42e6faf6e4e
http://link.springer.com/article/10.1038/s41598-020-67842-5
http://link.springer.com/article/10.1038/s41598-020-67842-5
Autor:
Pierre R. Bushel, Jianying Li, Han Wu, Frank Day, John N. Calley, Florian Caiment, Raegan O’Lone, Aaron P. Smith, Alison H. Harrill
Publikováno v:
Rna Biology, 17(5), 630-636. Landes Bioscience
RNA Biol
RNA Biol
MicroRNAs (miRNAs) are small RNAs that regulate mRNA expression and have been targeted as biomarkers of organ damage and disease. To explore the utility of miRNAs to assess injury to specific tissues, a tissue atlas of miRNA abundance was constructed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78381f7f8b966659542836a37b45c90
https://doi.org/10.1080/15476286.2020.1724715
https://doi.org/10.1080/15476286.2020.1724715
Autor:
Thejaswini Gopalappa, Joon Young Hur, John N. Calley, Isabella H. Wulur, Jeeyun Lee, Philip J. Ebert, Steven M. Bray, Ruslan D. Novosiadly, Jiangang Liu, Melinda D. Willard, Seung Tae Kim, Amit Aggarwal, Young Suk Park, Swee Seong Wong, Hui Rong Qian, Joon Oh Park, Ho Yeong Lim, Hee Cheol Kim, Won Ki Kang, Christoph Reinhard, Jason C. Ting
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Anti-EGFR antibodies are effective in therapies for late-stage colorectal cancer (CRC); however, many tumours are unresponsive or develop resistance. We performed genomic analysis of intrinsic and acquired resistance to anti-EGFR therapy in prospecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de14fcfac08a919f8125f92abff8b706
https://pubmed.ncbi.nlm.nih.gov/31653970
https://pubmed.ncbi.nlm.nih.gov/31653970
Autor:
Patricio O'Donnell, Christian Schubert, Tony Kam-Thong, Wayne C. Drevets, Amy Deep-Soboslay, Nicholas J. Brandon, David C. Airey, Andrew E. Jaffe, Laurent Essioux, James E. Scherschel, Mitsuyuki Matsumoto, Thomas M. Hyde, David A. Collier, Philip J. Ebert, Hartmuth C. Kolb, Michael Didriksen, Yushi Liu, Hui-Rong Qian, Alan J. Cross, Joo Heon Shin, Daniel R. Weinberger, Qi Wang, Kalpana M. Merchant, Laura Nisenbaum, Jens R. Wendland, Hualin S. Xi, Maura L. Furey, Richard E. Straub, John N. Calley, Ryan M. Smith, Cara L. Ruble, Jie Quan, Enrico Domenici, Ashley R. Winslow, Joel E. Kleinman, Husseini K. Manji, Takeshi Saito, Brian J. Eastwood, Hong Wang, Yankai Jia
Publikováno v:
Neuron. 88:1078-1083
We outline an ambitious project to characterize the genetic and epigenetic regulation of multiple facets of transcription in distinct brain regions across the human lifespan in samples of major neuropsychiatric disorders and controls. Initially focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6ebd47d9f461330d72fc5b6ac25e14
https://doi.org/10.1016/j.neuron.2015.10.047
https://doi.org/10.1016/j.neuron.2015.10.047
Autor:
Joon Young Hur, Hui-Rong Qian, Philip J. Ebert, Sun Young Kim, Hee Cheol Kim, Ruslan D. Novosiadly, Steven M. Bray, Christoph Reinhard, Jiangang Liu, Thejaswini Gopalappa, Isabella H. Wulur, Amit Aggarwal, Won Ki Kang, Jason C. Ting, Seung Tae Kim, Jeeyun Lee, Melinda D. Willard, John N. Calley, Ho Yeong Lim, Young Suk Park, Joon Oh Park, Swee Seong Wong
Publikováno v:
SSRN Electronic Journal.
Background: Anti-EGFR antibodies are effective therapies for many late-stage colorectal cancer (CRC) patients; however, many tumors are unresponsive or develop resistance. Methods: We performed whole exome sequencing and RNA sequencing of 25 CRC pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::653a4924c079ece3cac8d6031ead691c
https://doi.org/10.2139/ssrn.3307683
https://doi.org/10.2139/ssrn.3307683
Publikováno v:
International Journal of Systematic and Evolutionary Microbiology. 64:1166-1172
A novel bacterial strain, CMG1240T, was isolated in 1988 from mixed soil samples collected from the United States and South America in a selective enrichment medium with guar gum as the sole carbon source. This microbial isolate showed β-mannanolyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb7b63d1bb5ee54d3a0e6fc3bc9d32b
https://doi.org/10.1099/ijs.0.054726-0
https://doi.org/10.1099/ijs.0.054726-0
Autor:
Peter Davies, John N. Calley, Sarah Glover, Roger Moore, Amanda J. Bell, Suzanne C. Brewerton, Eric Karran, Annalisa Cavallini, Philip G. Szekeres, Michael Poidinger, Devaki Ramachandran, Clare Hardy, Michael Hutton, Suchira Bose, Samantha Sargent
Publikováno v:
Journal of Biological Chemistry. 288:23331-23347
Neurofibrillary tangles, one of the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates with synaptic loss and severi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4328d38f19e34dc88a7b7d6a434d84f9
https://doi.org/10.1074/jbc.m113.463984
https://doi.org/10.1074/jbc.m113.463984
Autor:
Sachin Mathur, Florian Caiment, Craig Fisher, Erik Koenig, David Greg Hall, Patrick Kirby, David E. Watson, Aaron P. Smith, Mark W. Farmen, John N. Calley, Pierre R. Bushel, Han Wu, Jianying Li, Hui-Rong Qian
Publikováno v:
BMC Genomics
BMC Genomics, 17:694. BioMed Central Ltd
BMC Genomics, 17:694. BioMed Central Ltd
Background MicroRNAs (miRNA) are ~19–25 nucleotide long RNA molecules that fine tune gene expression through the inhibition of translation or degradation of the mRNA through incorporation into the RNA induced silencing complex (RISC). MicroRNAs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f3f15378f8f133a3860806b066eda1
https://doi.org/10.1186/s12864-016-2956-z
https://doi.org/10.1186/s12864-016-2956-z
Autor:
Philip J. Ebert, Aimee Bence Lin, Ricardo Martinez, Jiangang Liu, Yan Ding, Gregory P. Donoho, Hui-Rong Qian, Richard P. Beckmann, John N. Calley, Wenjuan Wu, Philip W. Iversen, Emma T. Bowden, Amit Aggarwal
Publikováno v:
Cancer Research. 78:2586-2586
Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by poor clinical outcomes and limited treatment options. Transcriptional analysis has divided TNBC into different molecular subtypes (BL1, BL2, M and LAR) that were charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bab3de469e7635cb1a8d8901cd25b58f
https://doi.org/10.1158/1538-7445.am2018-2586
https://doi.org/10.1158/1538-7445.am2018-2586