Zobrazeno 1 - 10 of 26 pro vyhledávání: '"John N Mariani"'
1
Akademický článek
Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation.
Autor: Benjamin M Laitman, John N Mariani, Chi Zhang, Setsu Sawai, Gareth R John
Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170477 (2017)
Proper regulation of the coordinated transcriptional program that drives oligodendrocyte (OL) differentiation is essential for central nervous system myelin formation and repair. Nuclear import, mediated in part by a group of karyopherin alpha (Kpna)
Externí odkaz: https://doaj.org/article/a751b4fa70f34b4c93fd2a42d9e500cf
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2
Akademický článek
The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.
Autor: Benjamin M Laitman, Linnéa Asp, John N Mariani, Jingya Zhang, Jia Liu, Setsu Sawai, Candice Chapouly, Sam Horng, Elisabeth G Kramer, Nesanet Mitiku, Hannah Loo, Natalie Burlant, Xiomara Pedre, Yuko Hara, German Nudelman, Elena Zaslavsky, Young-Min Lee, David A Braun, Q Richard Lu, Goutham Narla, Cedric S Raine, Scott L Friedman, Patrizia Casaccia, Gareth R John
Publikováno v: PLoS Biology, Vol 14, Iss 5, p e1002467 (2016)
Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood. Here, we show that these effects are coordinated, in part, by the transcriptional
Externí odkaz: https://doaj.org/article/2dfa39249e6546189fb8f3c3d17cf445
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3
Akademický článek
Repression of developmental transcription factor networks triggers aging-associated gene expression in human glial progenitor cells
Autor: John N. Mariani, Benjamin Mansky, Pernille M. Madsen, Dennis Salinas, Deniz Kesmen, Nguyen P. T. Huynh, Nicholas J. Kuypers, Erin R. Kesel, Janna Bates, Casey Payne, Devin Chandler-Militello, Abdellatif Benraiss, Steven A. Goldman
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Human glial progenitor cells (hGPCs) exhibit diminished expansion competence with age, as well as after recurrent demyelination. Using RNA-sequencing to compare the gene expression of fetal and adult hGPCs, we identify age-related changes in
Externí odkaz: https://doaj.org/article/5d6bbb20559247ef91df3bdc2e5860bf
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4
Akademický článek
CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance
Autor: Masaki Takasugi, Naoko Ohtani, Kazuaki Takemura, Stephan Emmrich, Frances T. Zakusilo, Yuya Yoshida, Nobuyuki Kutsukake, John N. Mariani, Martha S. Windrem, Devin Chandler-Militello, Steven A. Goldman, Junko Satoh, Shinji Ito, Andrei Seluanov, Vera Gorbunova
Publikováno v: Cell Reports, Vol 42, Iss 9, Pp 113130- (2023)
Summary: The naked mole rat (NMR) is the longest-lived rodent, resistant to multiple age-related diseases including neurodegeneration. However, the mechanisms underlying the NMR’s resistance to neurodegenerative diseases remain elusive. Here, we is
Externí odkaz: https://doaj.org/article/04f80f73b8014e2e83d91863b9a4d47c
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5
Glial progenitor cells of the adult human white and grey matter are contextually distinct
Autor: Maria Joana Osorio, John N. Mariani, Lisa Zou, Steven J. Schanz, Kate Heffernan, Adam Cornwell, Steven A. Goldman
Publikováno v: Osorio, M J, Mariani, J N, Zou, L, Schanz, S J, Heffernan, K, Cornwell, A & Goldman, S A 2023, ' Glial progenitor cells of the adult human white and grey matter are contextually distinct ', Glia, vol. 71, no. 3, pp. 524-540 . https://doi.org/10.1002/glia.24291
Genomic analyses have revealed heterogeneity among glial progenitor cells (GPCs), but the compartment selectivity of human GPCs (hGPCs) is unclear. Here, we asked if GPCs of human grey and white brain matter are distinct in their architecture and ass
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0441d4589702f469309819dcba70240
https://doi.org/10.1002/glia.24291
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7
A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice
Autor: Abdellatif Benraiss, John N. Mariani, Ashley Tate, Pernille M. Madsen, Kathleen M. Clark, Kevin A. Welle, Renee Solly, Laetitia Capellano, Karen Bentley, Devin Chandler-Militello, Steven A. Goldman
Publikováno v: Benraiss, A, Mariani, J N, Tate, A, Madsen, P M, Clark, K M, Welle, K A, Solly, R, Capellano, L, Bentley, K, Chandler-Militello, D & Goldman, S A 2022, ' A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice ', Cell Reports, vol. 40, no. 9, 111291 . https://doi.org/10.1016/j.celrep.2022.111291
Huntington’s disease (HD) is characterized by defective oligodendroglial differentiation and white matter disease. Here, we investigate the role of oligodendrocyte progenitor cell (OPC) dysfunction in adult myelin maintenance in HD. We first note a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbe5e536dd7841c848b9b470d4e5249
https://pubmed.ncbi.nlm.nih.gov/36044851
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8
Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease
Autor: Martha S. Windrem, Mikhail Osipovitch, Devin Chandler-Militello, Abdellatif Benraiss, Steven A. Goldman, Carlos Benitez Villanueva, John N. Mariani, Adam Cornwell
Publikováno v: Benraiss, A, Mariani, J N, Osipovitch, M, Cornwell, A, Windrem, M S, Villanueva, C B, Chandler-Militello, D & Goldman, S A 2021, ' Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease ', Cell Reports, vol. 36, no. 1, 109308 . https://doi.org/10.1016/j.celrep.2021.109308
Glial pathology is a causal contributor to the striatal neuronal dysfunction of Huntington's disease (HD). We investigate mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to ident
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b206d15dbfad3f84e0ea8f4d27df81c8
https://curis.ku.dk/portal/da/publications/cellintrinsic-glial-pathology-is-conserved-across-human-and-murine-models-of-huntingtons-disease(c3ca9d6a-32a3-4218-8682-ce9366a925d3).html
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9
Glial progenitor cell-based repair of the dysmyelinated brain:Progression to the clinic
Autor: Pernille M. Madsen, John N. Mariani, Steven A. Goldman
Publikováno v: Goldman, S A, Mariani, J N & Madsen, P M 2021, ' Glial progenitor cell-based repair of the dysmyelinated brain : Progression to the clinic ', Seminars in Cell and Developmental Biology, vol. 116, pp. 62-70 . https://doi.org/10.1016/j.semcdb.2020.12.004
Semin Cell Dev Biol
Demyelinating disorders of the central white matter are among the most prevalent and disabling conditions in neurology. Since myelin-producing oligodendrocytes comprise the principal cell type deficient or lost in these conditions, their replacement
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfe5556dd2039b055ad6c88ea142728
https://curis.ku.dk/ws/files/334400670/nihms_1708427.pdf
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