The non-diuretic hypotensive effects of thiazides are enhanced during volume depletion states.

Autor: Saeed Alshahrani, Robert M Rapoport, Kamyar Zahedi, Min Jiang, Michelle Nieman, Sharon Barone, Andrea L Meredith, John N Lorenz, Jack Rubinstein, Manoocher Soleimani

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0181376 (2017)

Thiazide derivatives including Hydrochlorothiazide (HCTZ) represent the most common treatment of mild to moderate hypertension. Thiazides initially enhance diuresis via inhibition of the kidney Na+-Cl- Cotransporter (NCC). However, chronic volume dep

Externí odkaz: https://doaj.org/article/6163c2d7d96f4556820c9ee8f385b5ce

HuR inhibition reduces post-ischemic cardiac remodeling by dampening acute inflammatory gene expression and the innate immune response

Autor: Samuel Slone, Sarah R. Anthony, Lisa C. Green, Michelle L. Nieman, Perwez Alam, Xiaoqing Wu, Sudeshna Roy, Jeffrey Aube, Liang Xu, John N. Lorenz, A. Phillip Owens, Onur Kanisicak, Michael Tranter

Publikováno v: bioRxiv

Myocardial ischemia/reperfusion (I/R) injury and the resulting cardiac remodeling is a common cause of heart failure. The RNA binding protein Human Antigen R (HuR) has been previously shown to reduce cardiac remodeling following both I/R and cardiac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c616617f797378b82d427a86bdf37bc
https://europepmc.org/articles/PMC9882229/

Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility

Autor: Richard J. Gilbert, Thomas C. Irving, David M. Warshaw, Sakthivel Sadayappan, Weikang Ma, James W. McNamara, Gina Kuffel, Mayandi Sivaguru, Diederik W. D. Kuster, Paul M.L. Janssen, Burns C. Blaxall, Mohit Kumar, Dana M. Leichter, John N. Lorenz, Kyounghwan Lee, Michael J. Previs, Roger Craig, Michelle L. Nieman, Brian Lin, Thomas L. Lynch, Rohit R. Singh, Pieter P. de Tombe, Aaron M. Gibson, Michael J. Zilliox, Owen P. Leary

Publikováno v: Lynch, T L, Kumar, M, McNamara, J W, Kuster, D W D, Sivaguru, M, Singh, R R, Previs, M J, Lee, K H, Kuffel, G, Zilliox, M J, Lin, B L, Ma, W, Gibson, A M, Blaxall, B C, Nieman, M L, Lorenz, J N, Leichter, D M, Leary, O P, Janssen, P M L, de Tombe, P P, Gilbert, R J, Craig, R, Irving, T, Warshaw, D M & Sadayappan, S 2021, ' Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility ', Journal of Molecular and Cellular Cardiology, vol. 156, pp. 33-44 . https://doi.org/10.1016/j.yjmcc.2021.03.009
Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2021, 156, pp.33-44. ⟨10.1016/j.yjmcc.2021.03.009⟩
J Mol Cell Cardiol
Journal of Molecular and Cellular Cardiology, 156, 33-44. Academic Press Inc.

International audience; Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) regulates cardiac contraction through modulation of actomyosin interactions mediated by the protein's amino terminal (N′)-region (C0-C2 domains, 358 amino acids).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9aaf27df6df4e97fdee0c961f48de4d
https://doi.org/10.1016/j.yjmcc.2021.03.009

Pharmacologic Inhibition of Pain Response to Incomplete Vascular Occlusion Blunts Cardiovascular Preconditioning Response

Autor: Akiva, Kirschner, Sheryl E, Koch, Nathan, Robbins, Felix, Karthik, Parvathi, Mudigonda, Ranjani, Ramasubramanian, Michelle L, Nieman, John N, Lorenz, Jack, Rubinstein

Publikováno v: Cardiovascular toxicology. 21(11)

Complete vascular occlusion to distant tissue prior to an ischemic cardiac event can provide significant cardioprotection via remote ischemic preconditioning (RIPC). Despite understanding its mechanistic basis, its translation to clinical practice ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1cbe6b0e592b64ddd7174a4ec1810eaa
https://pubmed.ncbi.nlm.nih.gov/34324134

NBCe1 Na+-HCO3- cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo

Autor: Yigang Wang, Yinhua Chen, Kanimozhi Vairamani, Mario Medvedovic, Gary E. Shull, John N. Lorenz, Vikram Prasad, Wei Huang

Publikováno v: World Journal of Cardiology

AIM To investigate the hypothesis that cardiomyocyte-specific loss of the electrogenic NBCe1 Na+-HCO3- cotransporter is cardioprotective during in vivo ischemia-reperfusion (IR) injury. METHODS An NBCe1 (Slc4a4 gene) conditional knockout mouse (KO) m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b86bd3be4c266930aa164643f1913e9
http://europepmc.org/articles/PMC6189072