Zobrazeno 1 - 10
of 21
pro vyhledávání: '"John Millholland"'
Autor:
Natasha S. Hochberg, Srinivasa P. S. Rao, Gerhild Angyalosi, Xiaojun Zhao, Leticia Carballo, Caroline Demacq, Sofia Braud-Perez, Daniela Wieser, JP Casas, John Millholland, Debby Ngo
Publikováno v:
Frontiers in Parasitology, Vol 2 (2023)
Novel therapies for chronic indeterminate Chagas disease (CICD) are needed, but trials are limited by the absence of tests to detect infection and early treatment efficacy. This perspective highlights the shortfalls and strengths of polymerase chain
Externí odkaz:
https://doaj.org/article/c24db153dd35483e96c775d1ff263e9e
Autor:
Dominik Hartl, Valeria de Luca, Anna Kostikova, Jason Laramie, Scott Kennedy, Enrico Ferrero, Richard Siegel, Martin Fink, Sohail Ahmed, John Millholland, Alexander Schuhmacher, Markus Hinder, Luca Piali, Adrian Roth
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product and business model innovation, fundamentally changing the traditional approach of
Externí odkaz:
https://doaj.org/article/be644fa7db0840c4a7d56dccea721ede
Autor:
Erica M.F. Gotardo, Lidiane S. Torres, Lucas F.S. Gushiken, Pamela L. Brito, Flavia C. Leonardo, Sergei Agoulnik, Jiri Kovarik, Andreas Bruederle, John Millholland, Alessandra Vitaliti, Irmgard Förster, Fernando Ferreira Costa, Nicola Conran
Publikováno v:
Blood. 140:8230-8232
Autor:
Phillip M. Rappold, Lynda Vuong, Josef Leibold, Nicholas H. Chakiryan, Michael Curry, Fengshen Kuo, Erich Sabio, Hui Jiang, Briana G. Nixon, Ming Liu, Anders E. Berglund, Andrew W. Silagy, Eduardo A. Mascareno, Mahdi Golkaram, Mahtab Marker, Albert Reising, Alexander Savchenko, John Millholland, Ying-Bei Chen, Paul Russo, Jonathan Coleman, Ed Reznik, Brandon J. Manley, Irina Ostrovnaya, Vladimir Makarov, Renzo G. DiNatale, Kyle A. Blum, Xiaoxiao Ma, Diego Chowell, Ming O. Li, David B. Solit, Scott W. Lowe, Timothy A. Chan, Robert J. Motzer, Martin H. Voss, A. Ari Hakimi
Publikováno v:
Cancer Discov
It is poorly understood how the tumor immune microenvironment influences disease recurrence in localized clear-cell renal cell carcinoma (ccRCC). Here we performed whole-transcriptomic profiling of 236 tumors from patients assigned to the placebo-onl
Autor:
A. Ari Hakimi, Martin H. Voss, Robert J. Motzer, Timothy A. Chan, Scott W. Lowe, David B. Solit, Ming O. Li, Diego Chowell, Xiaoxiao Ma, Kyle A. Blum, Renzo G. DiNatale, Vladimir Makarov, Irina Ostrovnaya, Brandon J. Manley, Ed Reznik, Jonathan Coleman, Paul Russo, Ying-Bei Chen, John Millholland, Alexander Savchenko, Albert Reising, Mahtab Marker, Mahdi Golkaram, Eduardo A. Mascareno, Andrew W. Silagy, Anders E. Berglund, Ming Liu, Briana G. Nixon, Hui Jiang, Erich Sabio, Fengshen Kuo, Michael Curry, Nicholas H. Chakiryan, Josef Leibold, Lynda Vuong, Phillip M. Rappold
It is poorly understood how the tumor immune microenvironment influences disease recurrence in localized clear-cell renal cell carcinoma (ccRCC). Here we performed whole-transcriptomic profiling of 236 tumors from patients assigned to the placebo-onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af22d74b1526aba432a0f069b99d41d9
https://doi.org/10.1158/2159-8290.c.6549733.v1
https://doi.org/10.1158/2159-8290.c.6549733.v1
Autor:
A. Ari Hakimi, Martin H. Voss, Robert J. Motzer, Timothy A. Chan, Scott W. Lowe, David B. Solit, Ming O. Li, Diego Chowell, Xiaoxiao Ma, Kyle A. Blum, Renzo G. DiNatale, Vladimir Makarov, Irina Ostrovnaya, Brandon J. Manley, Ed Reznik, Jonathan Coleman, Paul Russo, Ying-Bei Chen, John Millholland, Alexander Savchenko, Albert Reising, Mahtab Marker, Mahdi Golkaram, Eduardo A. Mascareno, Andrew W. Silagy, Anders E. Berglund, Ming Liu, Briana G. Nixon, Hui Jiang, Erich Sabio, Fengshen Kuo, Michael Curry, Nicholas H. Chakiryan, Josef Leibold, Lynda Vuong, Phillip M. Rappold
Supplementary Figure from A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1ec763b13cff9a6658602529674209
https://doi.org/10.1158/2159-8290.22541734.v1
https://doi.org/10.1158/2159-8290.22541734.v1
Autor:
Autumn J. McRee, Takayuki Yoshino, Filip de Vos, Chloe E. Atreya, Eduard Gasal, Jan H.M. Schellens, Salvatore Siena, Eric Van Cutsem, Rona Yaeger, Thierry André, John Millholland, Ryan B. Corcoran, Antoine Hollebecque, Catarina D. Campbell, Josep Tabernero, Peter J. O'Dwyer, Fatima Rangwala, Johanna C. Bendell, Jan C. Brase, Yiqun Yang, Gary Middleton, Michael S. Gordon
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 26, iss 11
Purpose: The influence of the transcriptional and immunologic context of mutations on therapeutic outcomes with targeted therapy in cancer has not been well defined. BRAF V600E–mutant (BM) colorectal cancer comprises two main transcriptional subtyp
Autor:
Phillip M Rappold, Paul Russo, Mahtab Marker, Timothy A. Chan, Fengshen Kuo, A. Ari Hakimi, Albert Reising, John Millholland, Jonathan A. Coleman, Robert J. Motzer, Martin H. Voss, Andrew W. Silagy
Publikováno v:
Journal of Urology. 206
INTRODUCTION AND OBJECTIVE:Transcriptomic profiling of the renal cell carcinoma (RCC) tumor microenvironment (TME) has recently revealed gene signatures predictive of response to systemic therapy i...
Autor:
Jonathan A. Coleman, Robert J. Motzer, Timothy A. Chan, Andrew W. Silagy, Martin H. Voss, John Millholland, Mahtab Marker, Paul Russo, A. Ari Hakimi, Albert Reising, Fengshen Kuo, Phillip M Rappold
Publikováno v:
Journal of Clinical Oncology. 39:353-353
353 Background: Transcriptomic profiling of the renal cell carcinoma (RCC) tumor microenvironment (TME) has revealed gene signatures predictive of response to therapies in the metastatic setting. High expression of angiogenesis genes correlate with r
Autor:
Tong Luo, Anne-Marie Martin, Catherine Anne Sabatos-Peyton, Valerie Rezek, Alexander Savchenko, Marc Pelletier, Muchun Wang, Vanessa Rodrik-Outmezguine, Pushpa Jayaraman, John Millholland, Scott G. Kitchen, Rohan Diwanji, Wong Connie C, Jason Baum, Neil A. O'Brien, Kristine Rose, Glenn Dranoff, Elizabeth Choi, Ronald Linnartz
Publikováno v:
Cancer Research. 80:5640-5640
Introduction: TPI is a hallmark of cancer and plays a pivotal role in tumor initiation, development, progression, and invasiveness. High levels of tumor-promoting inflammatory cytokines e.g. IL-1β and IL-6 are associated with advanced malignancies a