Zobrazeno 1 - 10
of 41
pro vyhledávání: '"John Meekin"'
Autor:
Peter Zanvit, Dewald van Dyk, Christine Fazenbaker, Kelly McGlinchey, Weichuan Luo, Jessica M. Pezold, John Meekin, Chien-ying Chang, Rosa A. Carrasco, Shannon Breen, Crystal Sao-Fong Cheung, Ariel Endlich-Frazier, Benjamin Clark, Nina J. Chu, Alessio Vantellini, Philip L. Martin, Clare E. Hoover, Kenesha Riley, Steve M. Sweet, David Chain, Yeoun Jin Kim, Eric Tu, Nathalie Harder, Sandrina Phipps, Melissa Damschroder, Ryan N. Gilbreth, Mark Cobbold, Gordon Moody, Emily E. Bosco
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 22 (2023)
Prostate cancer is generally considered an immunologically “cold” tumor type that is insensitive to immunotherapy. Targeting surface antigens on tumors through cellular therapy can induce a potent antitumor immune response to “heat up” the tu
Externí odkaz:
https://doaj.org/article/e772d4b790a848fcb94aa4259efad645
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Marker genes for the monocyte-macrophage-DC subpopulations identified in Supplementary Figure 5H. Only genes with adjusted p-value < 0.01 and average log fold-change > 0.3 were included. gene, gene name; p_val, p-value calculated based on Wilcoxon te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318ab2f876a4f6d65d1cc34e89e50b21
https://doi.org/10.1158/2159-8290.22540394
https://doi.org/10.1158/2159-8290.22540394
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Pharmacodynamics of STAT3 ASO in CT26 STK11 KO model. (A) Percentage of CD45+ immune cells among live cells from untreated or drug-treated STK11 KO CT26 tumors as indicated. (B) Percentage of Ly6G+ granulocytic cells among live CD45+ cells. (C) Perce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c1f0437b345d54961ba0824610dcb6
https://doi.org/10.1158/2159-8290.22540439.v1
https://doi.org/10.1158/2159-8290.22540439.v1
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Supplementary Appendix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ac7dc7f83ade0389ea5b8926dfead1
https://doi.org/10.1158/2159-8290.22540454.v1
https://doi.org/10.1158/2159-8290.22540454.v1
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This study evaluated this association in patients with nonsquamous non–small cell lung cancer (NSCLC) enrolled in three phase I/II trials. STK11 mutations were associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99faa4f93ebec463e8a33a4c093c1abb
https://doi.org/10.1158/2159-8290.c.6549368.v1
https://doi.org/10.1158/2159-8290.c.6549368.v1
Autor:
David A. Tice, Philip W. Howard, Ronald Herbst, Kenneth C. Anderson, Luke Masterson, Michael J. Wick, Stephen J. Gregson, Sriram Sridhar, Kyriakos P. Papadopoulos, Alyssa Moriarty, Nazzareno Dimasi, Marlon C. Rebelatto, Christine Mione Kiefer, Sandrina Phipps, Yu-Tzu Tai, Arnaud C. Tiberghien, John Meekin, Krista Kinneer
Purpose:Antibody–drug conjugates (ADC) utilizing noncleavable linker drugs have been approved for clinical use, and several are in development targeting solid and hematologic malignancies including multiple myeloma. Currently, there are no reliable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80839c279aab8bddbee384f0cdadbd2b
https://doi.org/10.1158/1078-0432.c.6527396.v1
https://doi.org/10.1158/1078-0432.c.6527396.v1
Autor:
David A. Tice, Philip W. Howard, Ronald Herbst, Kenneth C. Anderson, Luke Masterson, Michael J. Wick, Stephen J. Gregson, Sriram Sridhar, Kyriakos P. Papadopoulos, Alyssa Moriarty, Nazzareno Dimasi, Marlon C. Rebelatto, Christine Mione Kiefer, Sandrina Phipps, Yu-Tzu Tai, Arnaud C. Tiberghien, John Meekin, Krista Kinneer
Supplementary methods and materials, and Supplemental Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f906385187323fe823fa7c557d5fdaf
https://doi.org/10.1158/1078-0432.22469939
https://doi.org/10.1158/1078-0432.22469939
Autor:
Robert Hollingsworth, Emil Michelotti, Nazzareno Dimasi, Andrew Buchanan, Philip Martin, Maureen Kennedy, David Stewart, John Meekin, Binyam Bezabeh, Ryan Fleming, Kelly McGlinchey, Kathy Mulgrew, Patrick Strout, Cui Chen, Allison Marrero, Jon Chesebrough, Leslie Wetzel, Raymond Rothstein, Jay Harper, Jonathan Rios-Doria
Figure S1. Expression of tumor-associated antigens in mouse tumor cell lines; Table S1. Number of complete responses in CT26 tumor-bearing mice that were treated with EphA2-Tub or EphA2-PBD; Figure S2. Activity of EphA2-Tub and EphA2-PBD in the Renca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15729cf380a40b828f0636c11caf6ec
https://doi.org/10.1158/0008-5472.22413317
https://doi.org/10.1158/0008-5472.22413317
Autor:
Robert Hollingsworth, Emil Michelotti, Nazzareno Dimasi, Andrew Buchanan, Philip Martin, Maureen Kennedy, David Stewart, John Meekin, Binyam Bezabeh, Ryan Fleming, Kelly McGlinchey, Kathy Mulgrew, Patrick Strout, Cui Chen, Allison Marrero, Jon Chesebrough, Leslie Wetzel, Raymond Rothstein, Jay Harper, Jonathan Rios-Doria
Immunogenic cell death (ICD) is the process by which certain cytotoxic drugs induce apoptosis of tumor cells in a manner that stimulates the immune system. In this study, we investigated whether antibody–drug conjugates (ADCS) conjugated with pyrro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6170bbc937f404240a8439cdd3db8730
https://doi.org/10.1158/0008-5472.c.6508682.v1
https://doi.org/10.1158/0008-5472.c.6508682.v1
Autor:
David A. Tice, Philip W. Howard, Ronald Herbst, Kenneth C. Anderson, Luke Masterson, Michael J. Wick, Stephen J. Gregson, Sriram Sridhar, Kyriakos P. Papadopoulos, Alyssa Moriarty, Nazzareno Dimasi, Marlon C. Rebelatto, Christine Mione Kiefer, Sandrina Phipps, Yu-Tzu Tai, Arnaud C. Tiberghien, John Meekin, Krista Kinneer
Supplementary table showing the relative expression of 43 target genes in a panel of EphA2-positive cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656bb05d0a44970a8add94d9221308b0
https://doi.org/10.1158/1078-0432.22469936.v1
https://doi.org/10.1158/1078-0432.22469936.v1