Zobrazeno 1 - 10
of 29
pro vyhledávání: '"John McNevin"'
Autor:
One B. Dintwe, Lamar Ballweber Fleming, Valentin Voillet, John McNevin, Aaron Seese, Anneta Naidoo, Saleha Omarjee, Linda-Gail Bekker, James G. Kublin, Stephen C. De Rosa, Evan W. Newell, Andrew Fiore-Gartland, Erica Andersen-Nissen, M. Juliana McElrath
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract A recent clinical trial demonstrated that Bacille Calmette-Guérin (BCG) revaccination of adolescents reduced the risk of sustained infection with Mycobacterium tuberculosis (M.tb). In a companion phase 1b trial, HVTN 602/Aeras A-042, we cha
Externí odkaz:
https://doaj.org/article/2df45c22cd2240a5b3efbdb7bbd386ce
Autor:
Marina Chan, Siddharth Vijay, John McNevin, M Juliana McElrath, Eric C Holland, Taranjit S Gujral
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Abstract Although 15–20% of COVID‐19 patients experience hyper‐inflammation induced by massive cytokine production, cellular triggers of this process and strategies to target them remain poorly understood. Here, we show that the N‐terminal do
Externí odkaz:
https://doaj.org/article/44d51e033dfc42b98ce0ad7ba88f050d
Autor:
Ryan M Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W Krizan, Awet Abraha, Denis M Tebit, Hong Zhao, Santiago Avila, Michael A Lobritz, M Juliana McElrath, Sylvie Le Gall, James I Mullins, Eric J Arts
Publikováno v:
PLoS Pathogens, Vol 5, Iss 4, p e1000365 (2009)
Human lymphocyte antigen (HLA)-restricted CD8(+) cytotoxic T lymphocytes (CTL) target and kill HIV-infected cells expressing cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication fi
Externí odkaz:
https://doaj.org/article/73d3c53637944733899bd6ed54aaad98
Autor:
Siddharth Vijay, John McNevin, M. Juliana McElrath, Taranjit S. Gujral, Marina Chan, Eric C. Holland
Publikováno v:
Molecular Systems Biology
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Although 15–20% of COVID‐19 patients experience hyper‐inflammation induced by massive cytokine production, cellular triggers of this process and strategies to target them remain poorly understood. Here, we show that the N‐terminal domain (NTD
Autor:
Martin Prlic, M. Juliana McElrath, Maxmillian Mpina, Stephen C. De Rosa, Raphael Gottardo, Claudia Daubenberger, Chloe K. Slichter, John McNevin, Mukta Dutta, Salim Abdulla, Stephen L. Hoffman, Marcel Tanner, Nicholas J. Maurice, Kenneth Stuart, Hannah W. Miller, Peter S. Linsley, Masanao Yajima
Publikováno v:
The Journal of Immunology. 199:107-118
Animal model studies highlight the role of innate-like lymphocyte populations in the early inflammatory response and subsequent parasite control following Plasmodium infection. IFN-γ production by these lymphocytes likely plays a key role in the ear
Autor:
Gabriela Diaz, Hannah W. Miller, Raphael Gottardo, Martin Prlic, Chloe K. Slichter, John McNevin, M. Juliana McElrath, Andrew McDavid, Greg Finak, Brenda J. Seymour, Julie Czartoski
Publikováno v:
JCI Insight. 1
Conventional memory CD8+ T cells and mucosal-associated invariant T cells (MAIT cells) are found in blood, liver, and mucosal tissues and have similar effector potential following activation, specifically expression of IFN-γ and granzyme B. To bette
Autor:
M. Juliana McElrath, Arjun Rustagi, John McNevin, Brian P. Doehle, Kristina Chang, Michael Gale
Publikováno v:
Journal of Virology. 86:8367-8374
HIV has evolved sophisticated mechanisms to avoid restriction by intracellular innate immune defenses that otherwise serve to control acute viral infection and virus dissemination. Innate defenses are triggered when pattern recognition receptor (PRR)
Autor:
John McNevin, Jaisri R. Lingappa, Jonathan C. Reed, Kevin C. Klein, Britta Molter, Samina Giri, Clair D. Geary, Julie McElrath
Publikováno v:
The Journal of Cell Biology
The RNA helicase DDX6 promotes HIV-1 assembly in a co-opted cellular complex containing P body proteins and ABCE1.
To produce progeny virus, human immunodeficiency virus type I (HIV-1) Gag assembles into capsids that package the viral genome and
To produce progeny virus, human immunodeficiency virus type I (HIV-1) Gag assembles into capsids that package the viral genome and
Autor:
John McNevin, Brook Vander Stoep Hunt, Kevin C. Klein, Beth K Thielen, Jaisri R. Lingappa, M. Juliana McElrath
Publikováno v:
Journal of Biological Chemistry. 285:27753-27766
In HIV-1-infected individuals, G-to-A hypermutation is found in HIV-1 DNA isolated from peripheral blood mononuclear cells (PBMCs). These mutations are thought to result from editing by one or more host enzymes in the APOBEC3 (A3) family of cytidine
Publikováno v:
Journal of Virology. 83:10395-10405
Interferon regulatory factor 3 (IRF-3) is essential for innate intracellular immune defenses that limit virus replication, but these defenses fail to suppress human immunodeficiency virus (HIV) infection, which can ultimately associate with opportuni