Zobrazeno 1 - 10
of 64
pro vyhledávání: '"John McGonigle"'
Autor:
Samuel Turton, Louise M. Paterson, James FM. Myers, Inge Mick, Chen-Chia Lan, John McGonigle, Henrietta Bowden-Jones, Luke Clark, David J. Nutt, Anne R. Lingford-Hughes
Publikováno v:
Neuroimage: Reports, Vol 4, Iss 3, Pp 100211- (2024)
Alcohol dependence (AD) and gambling disorder (GD) are common addiction disorders with significant physical and mental health consequences. AD and GD are associated with dysregulated responses to reward which could be due to a common mechanism of dys
Externí odkaz:
https://doaj.org/article/0c0ed09750da47048d97c96f3d5a9606
Autor:
Dawn Teare, Stuart McPherson, Preya Patel, Ahai Luvai, Kate Hallsworth, Quentin Anstee, Dina Mansour, Jill Dean, Helen Jarvis, Trevor Liddle, Joan Bedlington, John McGonigle, Elodie Hanon, Laura Renwick, Christina Tanney
Publikováno v:
BMJ Open Gastroenterology, Vol 10, Iss 1 (2023)
Introduction Undiagnosed fatty liver disease is prevalent in the community, due to high rates of harmful alcohol consumption and/or obesity. Fatty liver disease can progress to cirrhosis and its complications. Early identification of liver disease an
Externí odkaz:
https://doaj.org/article/814ca2688244451286ab2d2e219b83b6
Autor:
Ioanna A. Vamvakopoulou, Leon Fonville, Alexandra Hayes, John McGonigle, Rebecca Elliott, Karen D. Ersche, Remy Flechais, Csaba Orban, Anna Murphy, Dana G. Smith, John Suckling, Eleanor M. Taylor, Bill Deakin, Trevor W. Robbins, David J. Nutt, Anne R. Lingford-Hughes, Louise M. Paterson
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
IntroductionNegative affective states contribute to the chronic-relapsing nature of addiction. Mesolimbic dopamine D3 receptors are well placed to modulate emotion and are dysregulated in substance dependence. Selective antagonists might restore dopa
Externí odkaz:
https://doaj.org/article/4e8eb72042e4416497f16af44766cb8c
Publikováno v:
JMIR Medical Informatics, Vol 10, Iss 1, p e34038 (2022)
Artificial intelligence (AI) is a broad discipline that aims to understand and design systems that display properties of intelligence. Machine learning (ML) is a subset of AI that describes how algorithms and models can assist computer systems in pro
Externí odkaz:
https://doaj.org/article/6d08d8b2eaba4d61b75d4aa51b366193
Autor:
Adriana Roca-Fernández, Andrea Dennis, Rowan Nicholls, John McGonigle, Matthew Kelly, Rajarshi Banerjee, Amitava Banerjee, Arun J. Sanyal
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Objective: Obesity is a risk factor for SARS-COV2 infection and is often associated with hepatic steatosis. The aim of this study was to determine if pre-existing hepatic steatosis affects the risk of infection and severity for COVID-19.Design: Prosp
Externí odkaz:
https://doaj.org/article/d29bb3e833174b098ff1f0df9357effe
Autor:
Damian J Mole, Jonathan A Fallowfield, Ahmed E Sherif, Timothy Kendall, Scott Semple, Matt Kelly, Gerard Ridgway, John J Connell, John McGonigle, Rajarshi Banerjee, J Michael Brady, Xiaozhong Zheng, Michael Hughes, Lucile Neyton, Joanne McClintock, Garry Tucker, Hilary Nailon, Dilip Patel, Anthony Wackett, Michelle Steven, Fenella Welsh, Myrddin Rees, HepaT1ca Study Group
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0238568 (2020)
The risk of poor post-operative outcome and the benefits of surgical resection as a curative therapy require careful assessment by the clinical care team for patients with primary and secondary liver cancer. Advances in surgical techniques have impro
Externí odkaz:
https://doaj.org/article/efe9d90ff055482e9e64951c38de830b
Autor:
Liam J. Nestor, John Suckling, Karen D. Ersche, Anna Murphy, John McGonigle, Csaba Orban, Louise M. Paterson, Laurence Reed, Eleanor Taylor, Remy Flechais, Dana Smith, Edward T. Bullmore, Rebecca Elliott, Bill Deakin, Ilan Rabiner, Anne-Lingford Hughes, Barbara J. Sahakian, Trevor W. Robbins, David J. Nutt
Publikováno v:
NeuroImage: Clinical, Vol 27, Iss , Pp 102297- (2020)
The prevalent spatial distribution of abnormalities reported in cognitive fMRI studies in addiction suggests there are extensive disruptions across whole brain networks. Studies using resting state have reported disruptions in network connectivity in
Externí odkaz:
https://doaj.org/article/9987c11e6b0d4de496ea949fe410a846
Publikováno v:
PeerJ, Vol 6, p e5540 (2018)
Background Functional magnetic resonance imaging (fMRI) is a popular method for examining pharmacological effects on the brain; however, the BOLD response is dependent on intact neurovascular coupling, and potentially modulated by a number of physiol
Externí odkaz:
https://doaj.org/article/904cbe75d2bd4f1d81643af2953b5487
Autor:
Patrick Lyden, Alastair Buchan, Johannes Boltze, Marc Fisher, Saeed Ansari, Joseph P Broderick, Bruce CV Campbell, Napasri Chaisinanunkul, Christopher Chen, James C Grotta, Walid Haddad, Randa Hareedy, Michael D Hill, Gary Houser, Ashutosh P Jadhav, Pooja Khatri, W Taylor Kimberly, James I Koenig, William S Korinek, Jaren W Landen, Maarten G Lansberg, Lawrence L Latour, David S Liebeskind, Theodore E Liston, John Lynch, John McGonigle, Eva A Mistry, J Mocco, Kent E Pryor, Jeffrey L Saver, Sean I Savitz, Kevin N Sheth, Yoram Solberg, Achala Vagal, Chitra Venkatasubramanian, Nikolaos K Ziogas
Publikováno v:
Stroke. 52:3063-3071
Despite years of basic research and pioneering clinical work, ischemic stroke remains a major public health concern. Prior STAIR (Stroke Treatment Academic Industry Roundtable) conferences identified both failures of clinical trial design and failure
Autor:
Stanislau Hrybouski, Peter Seres, Christopher R. Madan, Ivor Cribben, Rawle Carter, John McGonigle, Fraser Olsen, Nikolai Malykhin
Publikováno v:
Brain Structure and Function. 226:1067-1098
Functional changes in the aging human brain have been previously reported using functional magnetic resonance imaging (fMRI). Earlier resting-state fMRI studies revealed an age-associated weakening of intra-system functional connectivity (FC) and age