Zobrazeno 1 - 10
of 69
pro vyhledávání: '"John Mastropaolo"'
Publikováno v:
European Neuropsychopharmacology. 20:207-210
NR2B-subtype-selective antagonists differ from MK-801, a nonselective NMDA receptor antagonist. MK-801 antagonizes electrical seizures at doses as low as 0.1 to 0.18 mg/kg and elicits popping at doses as low as 0.5 mg/kg, whereas ifenprodil and Ro 8-
Publikováno v:
European Neuropsychopharmacology. 18:814-819
The genetically-inbred Balb/c mouse strain shows heightened sensitivity to the ability of MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist, to raise the threshold voltage necessary to precipitate tonic hindlimb extension and elicit irr
Autor:
Katrice D. Long, Jessica A. Burket, Brooke L. Gaskins, John Mastropaolo, Richard B. Rosse, Stephen I. Deutsch
Publikováno v:
European Neuropsychopharmacology. 18:565-568
Twenty-four hours after mice are exposed to a single session of forced swimming in cold water, the ability of MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist, to antagonize electrically precipitated seizures is reduced. Conceivably, t
Publikováno v:
Clinical Neuropharmacology. 31:104-119
Chromatin remodeling is recognized as a major regulator of gene expression that can be influenced by inhibition of epigenetic mechanisms that result in stable, heritable, covalent modifications of histone proteins and their associated DNA. Epigenetic
Autor:
Nina R. Schooler, Barbara L. Schwartz, John Mastropaolo, Brooke L. Gaskins, Stephen I. Deutsch, Richard B. Rosse, Katrice D. Long
Publikováno v:
European Neuropsychopharmacology. 18:147-151
The regionally selective reduction of expression of the alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) in schizophrenia underlies impaired sensory inhibition, a possible endophenotype of the disorder. This ligand-gated ion channel receptor ha
Publikováno v:
Psychiatry Research. 145:87-94
Diminished facial expressivity is a common feature of schizophrenia that interferes with effective interpersonal communication. This study was designed to determine if real-time visual feedback improved the ability of patients with schizophrenia to i
Publikováno v:
Behavioural Brain Research. 153:419-422
The expression of the alpha7-nicotinic acetylcholine receptor is diminished in selected brain areas of patients with schizophrenia. This diminished expression may account for the pathophysiological deficits of sensory inhibition and smooth pursuit ey
Publikováno v:
Clinical Neuropharmacology. 26:277-283
In persons with Down syndrome, soluble Abeta peptides, which result from the processing of the amyloid precursor protein, appear in the brain decades before the extracellular deposition of neuritic plaques. These soluble amyloidogenic peptides accumu
Autor:
Richard B. Rosse, John Mastropaolo, Stephen I. Deutsch, Stefanie A. Horsfield, Barbara L. Schwartz, Vincent Tomasino
Publikováno v:
The International Journal of Psychiatry in Medicine. 32:337-344
Objective: There are preclinical data showing that fluoxetine stimulated expression of Brain Derived Neurotrophic Factor (BDNF) and its specific tyrosine kinase receptor, and caused neuritic elongation and increased dendritic branching density of CA3
Publikováno v:
European Journal of Pharmacology. 449:121-125
The phencyclidine (PCP) model of schizophrenia suggests that N -methyl- d -aspartate (NMDA) receptor hypofunction and its consequences may play an important role in the pathophysiology of this psychiatric disorder. Moreover, the schizophreniform psyc