Zobrazeno 1 - 10
of 16
pro vyhledávání: '"John Manion"'
Autor:
Tomislav Kokotović, Michiel Langeslag, Ewelina M. Lenartowicz, John Manion, Christopher W. Fell, Elham Alehabib, Abbas Tafakhori, Hossein Darvish, Eric J. Bellefroid, G. Gregory Neely, Michaela Kress, Josef M. Penninger, Vanja Nagy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
PR domain-containing member 12 (PRDM12) is a key developmental transcription factor in sensory neuronal specification and survival. Patients with rare deleterious variants in PRDM12 are born with congenital insensitivity to pain (CIP) due to the comp
Externí odkaz:
https://doaj.org/article/7ff96855ff3544fa92d3f284c35b0497
Autor:
Man-Tat Lau, John Manion, Jamie B. Littleboy, Lisa Oyston, Thang M. Khuong, Qiao-Ping Wang, David T. Nguyen, Daniel Hesselson, Jamie E. Seymour, G. Gregory Neely
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Box jellyfish venom causes tissue damage, pain, and death through unknown molecular mechanisms. Here, Lau et al. perform a CRISPR screen to identify genes required for venom action and use this information to develop an antidote that blocks venom-ind
Externí odkaz:
https://doaj.org/article/7783b05d2b904dac8b8436b3b11b2579
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Chronic pain afflicts as much as 50% of the population at any given time but our methods to address pain remain limited, ineffective and addictive. In order to develop new therapies an understanding of the mechanisms of painful sensitization is essen
Externí odkaz:
https://doaj.org/article/c8bb90711e1a4b9c81834ad754357378
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Motor Neuron Disease (MND) typically affects patients during the later stages of life, and thus, MND is having an increasingly devastating impact on diagnosed individuals, their families and society. The umbrella term MND refers to diseases which cau
Externí odkaz:
https://doaj.org/article/a2c4d0e47f5846d892f82f6a7851ec69
Autor:
Jodie Pearlman, John Manion, Travis Ruan, Leslie Caron, Matthew A. Waller, Gregory G. Neely, Elizabeth Ford
Publikováno v:
Cells
Neurodegenerative diseases are characterized by irreversible cell damage, loss of neuronal cells and limited regeneration potential of the adult nervous system. Pluripotent stem cells are capable of differentiating into the multitude of cell types th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999c564d46b4ab58f2965304a53ad0b5
https://pubmed.ncbi.nlm.nih.gov/33233861
https://pubmed.ncbi.nlm.nih.gov/33233861
Autor:
Leslie Caron, Lipin Loo, Mark Larance, Michael Costigan, G. Gregory Neely, John Manion, Thang M. Khuong, Jamie B. Littleboy, Dylan J. Harney, Travis Ruan
Publikováno v:
Pain. 161(2)
Neuropathic pain causes severe suffering, and most patients are resistant to current therapies. A core element of neuropathic pain is the loss of inhibitory tone in the spinal cord. Previous studies have shown that foetal GABAergic neuron precursors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e3f7ffe0867bfd41e915d401c11410
https://pubmed.ncbi.nlm.nih.gov/31972853
https://pubmed.ncbi.nlm.nih.gov/31972853
Autor:
Thang M, Khuong, Zina, Hamoudi, John, Manion, Lipin, Loo, Arjun, Muralidharan, G Gregory, Neely
Publikováno v:
Philos Trans R Soc Lond B Biol Sci
Nerve injury leads to devastating and often untreatable neuropathic pain. While acute noxious sensation (nociception) is a crucial survival mechanism and is conserved across phyla, chronic neuropathic pain is considered a maladaptive response owing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb1c7aa42f524e571ccdccc587085f26
https://pubmed.ncbi.nlm.nih.gov/31544607
https://pubmed.ncbi.nlm.nih.gov/31544607
Autor:
John Manion, Thang M. Khuong, Qiao-Ping Wang, Man-Tat Lau, G. Gregory Neely, Harry Towler, Lisa J. Oyston, Yong Qi Lin
Publikováno v:
Science Advances. 5
Injury can lead to devastating and often untreatable chronic pain. While acute pain perception (nociception) evolved more than 500 million years ago, virtually nothing is known about the molecular origin of chronic pain. Here we provide the first evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::049d57ca816b82c0041cc7332a09b171
https://doi.org/10.1126/sciadv.aaw4099
https://doi.org/10.1126/sciadv.aaw4099
Autor:
Thang M. Khuong, Man-Tat Lau, John Manion, Daniel Hesselson, G. Gregory Neely, Lisa J. Oyston, Qiao-Ping Wang, Jamie Seymour, Jamie B. Littleboy, David T. Nguyen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
The box jellyfish Chironex fleckeri is extremely venomous, and envenoming causes tissue necrosis, extreme pain and death within minutes after severe exposure. Despite rapid and potent venom action, basic mechanistic insight is lacking. Here we perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6710d450790a3ed5bf91fde472034ebe
https://doi.org/10.1038/s41467-019-09681-1
https://doi.org/10.1038/s41467-019-09681-1
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Frontiers in Neuroscience
Frontiers in Neuroscience
Motor Neuron Disease (MND) typically affects patients during the later stages of life, and thus, MND is having an increasingly devastating impact on diagnosed individuals, their families and society. The umbrella term MND refers to diseases which cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0424303baaaf5e1cbdaa7d2d6d209fb
https://doi.org/10.3389/fnins.2019.00331
https://doi.org/10.3389/fnins.2019.00331