A Point Mutation That Confers Constitutive Activity to CXCR4 Reveals That T140 Is an Inverse Agonist and That AMD3100 and ALX40-4C Are Weak Partial Agonists

Autor: Akane Omagari, Bodduluri Haribabu, James R. Broach, Stephen C. Peiper, Nobutaka Fujii, Hirokazu Tamamura, Wenbo Zhang, Jean-Marc Navenot, Kenichi Hiramatu, John Manfredi, Gang Pei

Publikováno v: Journal of Biological Chemistry. 277:24515-24521

CXCR4 is a G protein-coupled receptor for stromal-derived factor 1 (SDF-1) that plays a critical role in leukocyte trafficking, metastasis of mammary carcinoma, and human immunodeficiency virus type-1 infection. To elucidate the mechanism for CXCR4 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a32fd16b68f877585e394179b47940
https://doi.org/10.1074/jbc.m200889200

Yeast α Mating Factor Structure-Activity Relationship Derived from Genetically Selected Peptide Agonists and Antagonists of Ste2p

Autor: William T. Wiesler, Joshua Trueheart, James R. Broach, Dana M. Fowlkes, Devon R. Byrd, Juan J. Herrero, Christine Klein, John Manfredi

Publikováno v: Molecular and Cellular Biology. 16:4700-4709

alpha-Factor, a 13-amino-acid pheromone secreted by haploid alpha cells of Saccharomyces cerevisiae, binds to Ste2p, a seven-transmembrane, G-protein-coupled receptor present on haploid alpha cells, to activate a signal transduction pathway required

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1f333c6a2e2f88e391a52e4bb366de
https://doi.org/10.1128/mcb.16.9.4700

Contributors

Autor: Omar Abdul-Hadi, Ashutosh Acharya, Mir H. Ali, Carles Amat, G. Rebecca Aspinall, Matthew S. Austin, Khalid Azzam, B. Sonny Bal, Paul E. Beaulé, Benjamin Bender, Keith R. Berend, Michael E. Berend, Gurdeep S. Biring, Petros J. Boscainos, R. Stephen J. Burnett, William N. Capello, Isabelle Catelas, John C. Clohisy, Pablo Corona, Ross Crawford, J. de Beer, Ronald E. Delanois, Douglas A. Dennis, Anthony M. DiGioia, Bill Donnelly, Lawrence D. Dorr, Gavan P. Duffy, John Dumbleton, Michael J. Dunbar, Clive P. Duncan, Thomas A. Einhorn, C. Anderson Engh, Xavier Flores, Reinhold Ganz, Donald S. Garbuz, J.W.M. Gardeniers, Kevin L. Garvin, G.A. Gie, Kenneth A. Greene, Allan E. Gross, Ernesto Guerra, Mahmoud A. Hafez, Arlen D. Hanssen, Curtis W. Hartman, James W. Heitz, Kirby Hitt, Ginger E. Holt, William J. Hozack, Bill K. Huang, B. Jaramaz, Eric Jones, Michael Kain, Eoin C. Kavanagh, Stephen Kearns, Catherine F. Kellett, Tracy L. Kinsey, Brian A. Klatt, Gregg R. Klein, Frank R. Kolisek, George Koulouris, Steven Kurtz, Paul F. Lachiewicz, Jo-Ann Lee, P.D. Michael Leunig, David G. Lewallen, Jay R. Lieberman, Adolph V. Lombardi, William T. Long, P.J. Lusty, Steven J. MacDonald, Aditya Vikram Maheshwari, Ormonde M. Mahoney, Arthur L. Malkani, W. James Malone, John Manfredi, Michael Manley, Bassam A. Masri, James P. McAuley, Joseph C. McCarthy, John B. Medley, Michael A. Mont, William Morrison, Joseph P. Nessler, Michael Nogler, Michelle O'Neill, Alvin Ong, Fabio R. Orozco, Mark W. Pagnano, Panayiotis J. Papagelopoulos, Wayne G. Paprosky, Javad Parvizi, Frank A. Petrigliano, Simon Pickering, James Purtill, Amar S. Ranawat, Chitranjan S. Ranawat, Camilo Restrepo, Raymond R. Ropiak, Richard H. Rothman, B.W. Schreurs, Peter F. Sharkey, Klaus A. Siebenrock, Rafael J. Sierra, Franklin H. Sim, Mark J. Spangehl, Scott M. Sporer, R.G. Steele, Kate Sutton, Moritz Tannast, Marco Teloken, Andrew John Timperley, Slif D. Ulrich, Thomas Parker Vail, Eugene R. Viscusi, W.L. Walter, Aiguo Wang, Madhusudhan R. Yakkanti, D. Young, Eric J. Yue, Adam C. Zoga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df8b1b975dadf285bd82d70af680f901
https://doi.org/10.1016/b978-1-4160-5898-4.00068-9

Genetic selection in Saccharomyces of mutant mammalian adenylyl cyclases with elevated basal activities

Autor: S. Y. Lee, John Manfredi, Steven A. Haney, Jun Xu, E. Duzic, C. L. Ma, James R. Broach

Publikováno v: Molecular genetics and genomics : MGG. 265(6)

We show that co-expression of rat Galphas together with type I, II, IV, or VI mammalian adenylyl cyclase (AC) can suppress the growth defect of cyr1 strains of Saccharomyces cerevisiae, which lack a functional endogenous AC. Complemention of cvr1 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411f90363cb68c362e9e7e4395ee4f4b
https://pubmed.ncbi.nlm.nih.gov/11523785

Small Molecule Suppressors of Drosophila Kinesin Deficiency Rescue Motor Axon Development in a Zebrafish Model of Spinal Muscular Atrophy

Autor: Christine E. Beattie, Le T. Hao, Leena Bhoite, Andrew D. Gassman, John Manfredi, Chad Bradford, Chi-Bin Chien

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e74325 (2013)

Proximal spinal muscular atrophy (SMA) is the most common inherited motor neuropathy and the leading hereditary cause of infant mortality. Currently there is no effective treatment for the disease, reflecting a need for pharmacologic interventions th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade8907953768142d9421b7a57b070ca
https://doi.org/10.1371/journal.pone.0074325