Zobrazeno 1 - 10
of 21
pro vyhledávání: '"John Mancuso"'
Autor:
John Mancuso
Publikováno v:
Current Drug Synthesis. :253-264
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80608de7f3576e0710b6f5dbda721857
https://doi.org/10.1002/9781119847281.ch13
https://doi.org/10.1002/9781119847281.ch13
Autor:
Daniel Guay, Éric Lévesque, John Mancuso, Brian DeChristopher, David Chai, Guillaume Barbe, Bin Chen
Publikováno v:
The Journal of organic chemistry. 85(10)
The natural product koningic acid (KA) is a selective covalent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a critical node in the glycolysis pathway. While KA is available commercially, sources are limited and its cost becomes rapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ece988519453accde6e00dedeb28219
https://pubmed.ncbi.nlm.nih.gov/32312046
https://pubmed.ncbi.nlm.nih.gov/32312046
Autor:
Annie Doucet, Conor C. G. Scully, Eric Marsault, Jennifer L. Hickey, John Mancuso, Andrei K. Yudin, Marie-Claude Tremblay, Serge Zaretsky, Adam P. Treder
Publikováno v:
Chemistry - A European Journal. 21:9249-9255
The first solid-phase parallel synthesis of macrocyclic peptides using three-component coupling driven by aziridine aldehyde dimers is described. The method supports the synthesis of 9- to 18-membered aziridine-containing macrocycles, which are then
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fec27d9fb20ab0afc595bc9964c10f2
https://doi.org/10.1002/chem.201500068
https://doi.org/10.1002/chem.201500068
Autor:
Youla S. Tsantrizos, Cyrus M. Lacbay, Nicholas J. Bennett, Yih-Shyan Lin, Matthias Götte, John Mancuso
Publikováno v:
Journal of Medicinal Chemistry. 57:7435-7449
Bisphosphonates can mimic the pyrophosphate leaving group of the nucleotidyl transfer reaction and effectively inhibit RNA/DNA polymerases. In a search of HIV-1 reverse transcriptase (RT) inhibitors, a new chemotype of nonhydrolyzable purine diphosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8049fb091326c56b51c907527e1cb8fe
https://doi.org/10.1021/jm501010f
https://doi.org/10.1021/jm501010f
Autor:
Youla S. Tsantrizos, Kurt Dejgaard, Lekha Sleno, David Y. Thomas, Daniel D Waller, René Roy, Tze Chieh Shiao, Gregor Jansen, Makan Golizeh, Michael Sebag, Chloe Martel-Lorion, John Mancuso
Publikováno v:
Chembiochem : a European journal of chemical biology. 17(9)
The unfolded protein response (UPR) initiated by the transmembrane kinase/ribonuclease Ire1 has been implicated in a variety of diseases. Ire1, with its unique position in the UPR, is an ideal target for the development of therapies; however, the ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc62f3308db6b8bca6a410afe2682c3
https://pubmed.ncbi.nlm.nih.gov/26792008
https://pubmed.ncbi.nlm.nih.gov/26792008
Publikováno v:
Synlett. :247-250
Diphenylacetylenes are obtained when alkyllithium reagents are added to 3-aryl-2-fluorobenzothiophenes at low temperature. The aromatic ring-opening mechanism involves a nucleophilic addition of the alkyllithium to the sulfur atom of the thiophene. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98badb0e85e634f5c6d90fd9c5850736
https://doi.org/10.1055/s-2004-837230
https://doi.org/10.1055/s-2004-837230
Autor:
Mark Lautens, John Mancuso
Publikováno v:
Synlett. 2002:0394-0398
1,6-enynes can be cyclized to 5-membered ring products bearing (tributylstannyl)methyl and exo-methylenylsilane moieties. The reaction is accomplished using either a Pd(0)/Cy 2 P(o-biphenyl) complex or a cationic N-heterocyclic carbene-based Pd(II) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69babff7134c72868f7225ae15029253
https://doi.org/10.1055/s-2002-20449
https://doi.org/10.1055/s-2002-20449
Publikováno v:
Bioorganicmedicinal chemistry. 21(8)
Thienopyrimidine-based bisphosphonates were identified as a new class of nitrogen-containing bisphosphonate (N-BP) inhibitors of the human farnesyl pyrophosphate synthase (hFPPS). Analogs were prepared via cyclization of 2-(1-(trimethylsilyl)ethylide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7dc43cc6cce3b5afe36968f67e71d36
https://pubmed.ncbi.nlm.nih.gov/23477945
https://pubmed.ncbi.nlm.nih.gov/23477945
Autor:
Mark Lautens, John Mancuso
Publikováno v:
ChemInform. 31
[reaction: see text] Treatment of 1,6-enynes with tri(n-butyl)tin hydride in the presence of a catalytic amount of palladium acetate leads to the formation of exo-methylenecyclopentanes bearing a tri(n-butyl)stannylmethyl moiety.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98991308f8e4c4cb0509fb5778ff285e
https://doi.org/10.1002/chin.200026175
https://doi.org/10.1002/chin.200026175
Autor:
Mark Lautens, John Mancuso
Publikováno v:
ChemInform. 33
1,6-enynes can be cyclized to 5-membered ring products bearing (tributylstannyl)methyl and exo-methylenylsilane moieties. The reaction is accomplished using either a Pd(0)/Cy 2 P(o-biphenyl) complex or a cationic N-heterocyclic carbene-based Pd(II) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96d1a87e5ea3b39d580b8cd4e09c2cd2
https://doi.org/10.1002/chin.200228225
https://doi.org/10.1002/chin.200228225