Zobrazeno 1 - 10
of 15
pro vyhledávání: '"John Man-Tak Chu"'
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Introduction Glucose transporter 1 (GLUT1) is essential for glucose transport into the brain and is predominantly expressed in the cerebral microvasculature. Downregulation of GLUT1 precedes the development of cognitive impairment in neurode
Externí odkaz:
https://doaj.org/article/aaedea4c6f58481ab3d3e4a99358145b
Autor:
John Man Tak Chu, Suki Pak Wing Chiu, Jiaqi Wang, Raymond Chuen Chung Chang, Gordon Tin Chun Wong
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-16 (2024)
Abstract Background The number of major operations performed in obese patients is expected to increase given the growing prevalence of obesity. Obesity is a risk factor for a range of postoperative complications including perioperative neurocognitive
Externí odkaz:
https://doaj.org/article/f17fe75f105e4a94b5ecd75941d52753
Autor:
Yan Liu, John Man Tak Chu, You Ran, Yan Zhang, Raymond Chuen Chung Chang, Gordon Tin Chun Wong
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-21 (2022)
Abstract Background Postoperative neurocognitive dysfunction remains a significant problem in vulnerable groups such as the elderly. While experimental data regarding its possible pathogenic mechanisms accumulate, therapeutic options for this disorde
Externí odkaz:
https://doaj.org/article/541d0b486ec2469a94a226534f1bdecf
Autor:
John Man Tak Chu, Amina Abulimiti, Brian Shing Hei Wong, Guan Ding Zhao, Shi Hang Xiong, Ming Ming Zhao, Yingyi Wang, Ying Chen, Jiaqi Wang, Yan Zhang, Raymond Chuen Chung Chang, Hua Yu, Gordon Tin Chun Wong
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Neuroinflammation is closely related to the pathogenesis of perioperative neurocognitive disorders (PNDs), which is characterized by the activation of microglia, inflammatory pathways and the release of inflammatory mediators. Sigesbeckia orientalis
Externí odkaz:
https://doaj.org/article/3eabb4be3fc341baa36948861cc6a0a9
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 337 (2022)
The functions of the complement system to both innate and adaptive immunity through opsonization, cell lysis, and inflammatory activities are well known. In contrast, the role of complement in the central nervous system (CNS) which extends beyond imm
Externí odkaz:
https://doaj.org/article/c22035e076b747e695cc3a38609d1f56
Autor:
Chunxia Huang, John Man Tak Chu, Yan Liu, Vivian Suk Wai Kwong, Raymond Chuen Chung Chang, Gordon Tin Chun Wong
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 11; Pages: 6250
Perioperative neurocognitive disorders are frequently observed in postoperative patients and previous reports have shown that pre-existing mild cognitive impairment with accumulated neuropathology may be a risk factor. Sevoflurane is a general anesth
Publikováno v:
Biomolecules. 12(4)
Glutamate is the major excitatory neurotransmitter in the central nervous system and is intricately linked to learning and memory. Its activity depends on the expression of AMPA and NMDA receptors and excitatory amino transporters on neurons and glia
Publikováno v:
Biomolecules. 12(2)
The functions of the complement system to both innate and adaptive immunity through opsonization, cell lysis, and inflammatory activities are well known. In contrast, the role of complement in the central nervous system (CNS) which extends beyond imm
Akademický článek
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Publikováno v:
Journal of neurochemistry. 123(3)
Neurokinin 3 (NK3) receptor is predominantly expressed in striatum and substantia nigra (SN). Evidences have indicated the roles of NK3 receptor in the pathogenesis of Parkinson's disease. By administrating NK3 receptor agonist senktide into 6-hydrox