Zobrazeno 1 - 10
of 38
pro vyhledávání: '"John Maciejowski"'
Autor:
Sunwoo Oh, Elodie Bournique, Danae Bowen, Pégah Jalili, Ambrocio Sanchez, Ian Ward, Alexandra Dananberg, Lavanya Manjunath, Genevieve P. Tran, Bert L. Semler, John Maciejowski, Marcus Seldin, Rémi Buisson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The cytidine deaminase APOBEC3A is a main source of mutagenesis in many types of cancer. Here the authors reveal that transient up-regulation of APOBEC3A and other pro-inflammatory genes can occur due to viral infection and genotoxic stress via multi
Externí odkaz:
https://doaj.org/article/f03f488fd0c5499ab43ab73627e76395
Autor:
Eléonore Toufektchan, John Maciejowski
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100378- (2021)
Summary: Micronuclei are aberrant nuclear compartments that form when chromosomes or chromosome fragments fail to incorporate into a primary nucleus during mitotic exit. Ruptures at the micronuclear envelope are associated with DNA damage and activat
Externí odkaz:
https://doaj.org/article/9f20432ba70048d6b2a9331c1e272d5a
Autor:
Patrick von Morgen, John Maciejowski
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-4 (2018)
Editorial summary Telomere crisis is linked with many of the genomic alterations found in cancer genomes. A new understanding of how these alterations arise points towards an active role for innate immune sensors during crisis and to new opportunitie
Externí odkaz:
https://doaj.org/article/ca7cda63b57f44ef82a58dea3e27a3e6
Autor:
Rebecca E. McIntyre, Jérôme Nicod, Carla Daniela Robles-Espinoza, John Maciejowski, Na Cai, Jennifer Hill, Ruth Verstraten, Vivek Iyer, Alistair G. Rust, Gabriel Balmus, Richard Mott, Jonathan Flint, David J. Adams
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 8, Pp 2343-2354 (2016)
In mammals the regulation of genomic instability plays a key role in tumor suppression and also controls genome plasticity, which is important for recombination during the processes of immunity and meiosis. Most studies to identify regulators of geno
Externí odkaz:
https://doaj.org/article/6b12f11393a14aaabd82a63bacdd0e90
Autor:
Mark E Burkard, John Maciejowski, Verónica Rodriguez-Bravo, Michael Repka, Drew M Lowery, Karl R Clauser, Chao Zhang, Kevan M Shokat, Steven A Carr, Michael B Yaffe, Prasad V Jallepalli
Publikováno v:
PLoS Biology, Vol 7, Iss 5, p e1000111 (2009)
Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation relies on positional cues pr
Externí odkaz:
https://doaj.org/article/efcc32a4efcb4dc7bae4cafa4776e364
Publikováno v:
Nat Genet
Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC)3 cytosine deaminase activity have been found in over half of cancer types, including some therapy-resistant and metastatic tumors. Driver m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43860e52f321f980d4818eec01259608
https://doi.org/10.1038/s41588-022-01196-8
https://doi.org/10.1038/s41588-022-01196-8
Supplementary Figure 1. FACS analysis of cells with Rb or p53 depletion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d595231e1eef765d1f340e9ad8ed106f
https://doi.org/10.1158/1541-7786.22511212
https://doi.org/10.1158/1541-7786.22511212
CRISPR-Cas mediated homology-directed repair (HDR) can flexibly introduce desired mutations at targeted sites in a genome. But achieving high HDR efficiencies is a major hurdle in many cellular contexts. Moreover, cells from patients with mutations i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c46b249e2e74e768f82547f366697a6
https://doi.org/10.1101/2022.12.12.520063
https://doi.org/10.1101/2022.12.12.520063
Autor:
Albert Agustinus, Ramya Raviram, Bhargavi Dameracharla, Jens Luebeck, Stephanie Stransky, Lorenzo Scipioni, Robert M. Myers, Melody Di Bona, Mercedes Duran, Britta Weigelt, Shira Yomtoubian, Eléonore Toufektchan, Paul S. Mischel, Vivek Mittal, Sohrab Shah, John Maciejowski, Enrico Gratton, Peter Ly, Mathieu F. Bakhoum, Dan Landau, Vineet Bafna, Simone Sidoli, Yael David, Samuel F. Bakhoum
Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers [1-4], yet whether they are mechanistically linked is unknown. Here we show that missegregation of mitotic chromosomes, their sequestratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bca96ab2ad7e1411c903ace33782445f
https://doi.org/10.1101/2022.01.12.475944
https://doi.org/10.1101/2022.01.12.475944
Autor:
Albert S. Agustinus, Ramya Raviram, Bhargavi Dameracharla, Jens Luebeck, Stephanie Stransky, Lorenzo Scipioni, Robert M. Myers, Melody Di Bona, Mercedes Duran, Britta Weigelt, Shira Yomtoubian, Eleonore Toufektchan, Paul S. Mischel, Vivek Mittal, Sohrab Shah, John Maciejowski, Enrico Gratton, Peter Ly, Mathieu F. Bakhoum, Dan Landau, Vineet Bafna, Simone Sidoli, Yael David, Samuel F. Bakhoum
Publikováno v:
Cancer Research. 82:3768-3768
Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers, yet whether they are mechanistically linked is unknown. Here we show that missegregation of mitotic chromosomes, their sequestration in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18a6f16ec658a478a97dc7ccb98078d
https://doi.org/10.1158/1538-7445.am2022-3768
https://doi.org/10.1158/1538-7445.am2022-3768