Výsledky vyhledávání - "John M. van Baal"

High-performance liquid chromatographic determination of purine and pyrimidine bases, ribonucleosides, deoxyribonucleosides and cyclic ribonucleotides in biological fluids

Autor: An A.J.M. Bakkeren, Chris H.M.M. De Bruyn, John M. van Baal, E. D. A. M. Schretlen, Ronney A. De Abreu

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 229:67-75

A method is presented for the separation and quantitative determination of compounds normally related to purine and pyrimidine metabolism in biological material. The retention behaviour of nucleobases, ribonucleosides, deoxyribonucleosides and cyclic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d7303f425763297da6f7f2f3ad3d9f
https://doi.org/10.1016/s0378-4347(00)86037-5

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Inhibition of lymphoid cell growth by adenine ribonucleotide accumulation. The role of phosphoribosylpyrophosphate-depletion induced pyrimidine starvation

Autor: Ronney A. De Abreu, John M. van Baal, Peter M. van Zandvoort, Jan A.J.M. Bakkeren, Peter M. van der Kraan

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 927:213-221

The exact role of adenosine in the adenosine deaminase (EC 3.5.4.4) deficiency-related severe combined immunodeficiency disease has not been ascertained. We analysed the effects of adenosine, in the presence of the adenosine deaminase inhibitor, deox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d799effa882f1c63dc6912178163e9
https://doi.org/10.1016/0167-4889(87)90137-6

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Influence of Methotrexate on Purine and Pyrimidine Pools and on Cell Phase Distribution of Cultured Human Lymphoblasts

Autor: Jos P.M. Bökkerink, Tilly W. Hulscher, John M. van Baal, Ronney A. De Abreu, E. D. A. M. Schretlen, Chris H. M. M. de Bruijn, Marinka A.H. Bakker

Publikováno v: Purine and Pyrimidine Metabolism in Man V ISBN: 9781468412505

Methotrexate (MTX) and 6-mercaptopurine (6MP) are among the most commonly used agents in the maintenance treatment of acute lymphoblastic leukemia (ALL) in children.1-3 There are biochemical considerations for an increased efficacy of a combination o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd97e8c597cf4ce043a3e7bc2a8d4507
https://doi.org/10.1007/978-1-4684-1248-2_17

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Effects of methotrexate on purine and pyrimidine metabolism and cell-kinetic parameters in human malignant lymphoblasts of different lineages

Autor: Tilly W. Hulscher, Ronney A. De Abreu, Chris H. M. M. de Bruijn, Marinka A.H. Bakker, Jos P.M. Bökkerink, E. D. A. M. Schretlen, John M. van Baal

Publikováno v: Biochemical pharmacology. 37(12)

MOLT-4 (T−), RAJI (B−), and KM-3 (non-B-non-T-, common ALL) malignant lymphoblasts demonstrated significant differences in their activities of purine de novo synthesis (PDNS) and purine salvage pathway and in their cell-kinetic parameters. Incuba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba7081333530985d3e167de9c5a4dd8
https://pubmed.ncbi.nlm.nih.gov/2455520

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The effect of methotrexate on purine and pyrimidine deoxyribonucleoside triphosphate pools and on cell viability and cell-phase distribution in malignant human T- and B-lymphoblasts

Autor: Tilly W. Hulscher, John M. van Baal, Ronney A. De Abreu, Marinka A.H. Bakker, Jos P.M. Bökkerink

Publikováno v: The Role of Pharmacology in Pediatric Oncology ISBN: 9789401083959

Methotrexate (MTX) and 6-mercaptopurine (6-MP) are widely used in the maintenance treatment of acute lymphoblastic leukemia (ALL) in children. Based on their biochemical interactions there are reasons to support a combination therapy of both drugs. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::766cbf6b7e4a44e2ae75ffd0ae60a320
https://doi.org/10.1007/978-94-009-4267-7_14

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High-performance liquid chromatographic assay for identification and quantitation of nucleotides in lymphocytes and malignant lymphoblasts

Autor: E. D. A. M. Schretlen, John M. van Baal, Jan A.J.M. Bakkeren, Chris H.M.M. De Bruyn, Ronney A. De Abreu

Publikováno v: Journal of chromatography. 227(1)

A method for the identification and quantitation of nucleotide pools in lymphocytes and leukemic blasts is described. Separation of these metabolites was performed by anion-exchange high-performance liquid chromatography using a pH and concentration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a478bcb786eeaa9451b1fe2f7f862c1
https://pubmed.ncbi.nlm.nih.gov/7056821

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Autor: Ronney A. De Abreu, Gerard A. M. de Vaan, Jos P.M. Bökkerink, Tilly W. Hulscher, Marinka A.H. Bakker, John M. van Baal

Publikováno v: Biochemical pharmacology. 35(20)

The effects of methotrexate (MTX) on cytotoxicity (trypan blue exclusion and soft agar clonal growth), cell cycle perturbation, and purine and pyrimidine ribonucleotide and deoxyribonucleotide pools have been studied in MOLT-4 malignant T-lymphoblast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02a98a7050991b89f870943fbcf0d7b
https://pubmed.ncbi.nlm.nih.gov/2429668

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