Zobrazeno 1 - 10
of 13
pro vyhledávání: '"John M. van Baal"'
Autor:
An A.J.M. Bakkeren, Chris H.M.M. De Bruyn, John M. van Baal, E. D. A. M. Schretlen, Ronney A. De Abreu
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 229:67-75
A method is presented for the separation and quantitative determination of compounds normally related to purine and pyrimidine metabolism in biological material. The retention behaviour of nucleobases, ribonucleosides, deoxyribonucleosides and cyclic
Autor:
Ronney A. De Abreu, John M. van Baal, Peter M. van Zandvoort, Jan A.J.M. Bakkeren, Peter M. van der Kraan
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 927:213-221
The exact role of adenosine in the adenosine deaminase (EC 3.5.4.4) deficiency-related severe combined immunodeficiency disease has not been ascertained. We analysed the effects of adenosine, in the presence of the adenosine deaminase inhibitor, deox
Publikováno v:
Journal of chromatography. 336(2)
Autor:
Jos P.M. Bökkerink, Tilly W. Hulscher, John M. van Baal, Ronney A. De Abreu, E. D. A. M. Schretlen, Chris H. M. M. de Bruijn, Marinka A.H. Bakker
Publikováno v:
Purine and Pyrimidine Metabolism in Man V ISBN: 9781468412505
Methotrexate (MTX) and 6-mercaptopurine (6MP) are among the most commonly used agents in the maintenance treatment of acute lymphoblastic leukemia (ALL) in children.1-3 There are biochemical considerations for an increased efficacy of a combination o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd97e8c597cf4ce043a3e7bc2a8d4507
https://doi.org/10.1007/978-1-4684-1248-2_17
https://doi.org/10.1007/978-1-4684-1248-2_17
Autor:
Ronney A. De Abreu, John M. van Baal, E. D. A. M. Schretlen, Chris H.M.M. De Bruyn, T. J. Schouten
Publikováno v:
Journal of chromatography. 227(2)
Autor:
Tilly W. Hulscher, Ronney A. De Abreu, Chris H. M. M. de Bruijn, Marinka A.H. Bakker, Jos P.M. Bökkerink, E. D. A. M. Schretlen, John M. van Baal
Publikováno v:
Biochemical pharmacology. 37(12)
MOLT-4 (T−), RAJI (B−), and KM-3 (non-B-non-T-, common ALL) malignant lymphoblasts demonstrated significant differences in their activities of purine de novo synthesis (PDNS) and purine salvage pathway and in their cell-kinetic parameters. Incuba
Autor:
Tilly W. Hulscher, John M. van Baal, Ronney A. De Abreu, Marinka A.H. Bakker, Jos P.M. Bökkerink
Publikováno v:
The Role of Pharmacology in Pediatric Oncology ISBN: 9789401083959
Methotrexate (MTX) and 6-mercaptopurine (6-MP) are widely used in the maintenance treatment of acute lymphoblastic leukemia (ALL) in children. Based on their biochemical interactions there are reasons to support a combination therapy of both drugs. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::766cbf6b7e4a44e2ae75ffd0ae60a320
https://doi.org/10.1007/978-94-009-4267-7_14
https://doi.org/10.1007/978-94-009-4267-7_14
Autor:
E. D. A. M. Schretlen, John M. van Baal, Jan A.J.M. Bakkeren, Chris H.M.M. De Bruyn, Ronney A. De Abreu
Publikováno v:
Journal of chromatography. 227(1)
A method for the identification and quantitation of nucleotide pools in lymphocytes and leukemic blasts is described. Separation of these metabolites was performed by anion-exchange high-performance liquid chromatography using a pH and concentration
Autor:
Ronney A. De Abreu, Gerard A. M. de Vaan, Jos P.M. Bökkerink, Tilly W. Hulscher, Marinka A.H. Bakker, John M. van Baal
Publikováno v:
Biochemical pharmacology. 35(20)
The effects of methotrexate (MTX) on cytotoxicity (trypan blue exclusion and soft agar clonal growth), cell cycle perturbation, and purine and pyrimidine ribonucleotide and deoxyribonucleotide pools have been studied in MOLT-4 malignant T-lymphoblast
Autor:
Jos P.M. Bökkerink, Tilly W. Hulscher, John M. van Baal, E. D. A. M. Schretlen, Ronney A. De Abreu, Chris H.M.M. De Bruyn, Marinka A.H. Bakker
Publikováno v:
Pediatric Research. 19:752-752
INFLUENCE OF METHOTREXATE ON PURINE AND PYRIMIDINI POOLS AND ON CELL PHASE DISTRIBUTION OF CULTURED HUMAN LYMPHOBLASTS: 50