Zobrazeno 1 - 10
of 24
pro vyhledávání: '"John M. Trang"'
Publikováno v:
Clinical Pharmacology in Drug Development
Cachexia occurs in up to 80% of patients with advanced cancer and is characterized by involuntary weight loss, frequently accompanied by anorexia and altered metabolism.1–5 It is associated with poorer survival, a decline in physical functioning an
Autor:
Tulin Cagatay, Amy M. Sturmer, John M. Trang, Roxanne Tavakkol, Sheela Mitta, Nozer M. Mehta, William Stern, Jenna Giacchi, Jeff Wald, Lorraine A. Fitzpatrick
Publikováno v:
Clinical Pharmacokinetics. 52:995-1004
Teriparatide [rhPTH(1–34)OH] is a subcutaneously administered bone anabolic drug that increases bone mineral density (BMD) and reduces the risk of osteoporotic fracture. Because rhPTH(1–34)OH is administered by injection, oral delivery is a desir
Publikováno v:
The Journal of Clinical Pharmacology. 42:1318-1325
The pharmacokinetics of toborinone was studied in subjects with congestive heart failure (CHF) and concomitant renal and/or hepatic disease. At the time of admission, subjects were grouped based on estimated creatinine clearance and serum bilirubin.
Autor:
Brinda Tammara, Steven L. Bramer, Gohachiro Miyamoto, Jerry H Brisson, John M. Trang, Mami Kitani
Publikováno v:
The Journal of Clinical Pharmacology. 42:492-500
This study investigated the effects of the concomitant administration of theophylline and toborinone on the pharmacokinetics of both compounds in poor and extensive metabolizers via CYP2D6. In period 1, a single dose of 3.5 mg/kg theophylline was adm
Publikováno v:
Clinical Drug Investigation. 9:206-211
We conducted a multiple dose, open-label study to evaluate the serum concentrations of cefotaxime (CTX) and desacetylcefotaxime (dCTX) in infants and children following a 75.0 mg/kg dose of CTX given on an 8-hourly schedule. 12 hospitalised infants a
Autor:
John M Trang, Lauren Kidd, William Gruber, Gregory Storch, Gail Demmler, Richard Jacobs, Wayne Dankner, Stuart Starr, Robert Pass, Sergio Stagno, Charles Alford, Seng-jaw Soong, Richard J Whitley, Jean-Pierre Sommadossi, Niaid Collaborative Antiviral Study Group
Publikováno v:
Clinical Pharmacology and Therapeutics. 53:15-21
The pharmacokinetic characteristics of ganciclovir were determined in neonates (age range, 2 to 49 days) after an 1-hour intravenous infusion of a single dose of either 4 mg/kg (n = 14) or 6 mg/kg (n = 13). Twenty-seven newborns with symptomatic cyto
Autor:
P Reuman, Jean Pierre Sommadossi, William Gruber, G Demmler, John M. Trang, M Shelton, Robert F. Pass, X.J. Zhou, S Adler, B Britt, R Jacobs, Richard J. Whitley
The population pharmacokinetics of ganciclovir was investigated in a group of 27 newborns with symptomatic congenital cytomegalovirus infection by nonlinear mixed-effects modeling analysis. Individual characteristics including approximated creatinine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d508136b71aa0000916b595d708f56
https://europepmc.org/articles/PMC163500/
https://europepmc.org/articles/PMC163500/
Autor:
Jeffrey E. Lancet, Jonathan E. Kolitz, Lawrence D. Mayer, Chris E. Swenson, John M. Trang, Arthur C. Louie, Michael Chiarella, Eric J. Feldman
Publikováno v:
Cancer Research. 71:1292-1292
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Background: CPX-351 is a liposomal formulation that co-encapsulates Cyt and Daun enabling delivery of both drugs at a synergistic 5:1 molar ratio. A Phase I study in advan
Autor:
John M. Trang
Publikováno v:
Pharmaceutical Biotechnology ISBN: 9781489923318
Biotechnology has been described as the third great technological revolution of the 20th century, following atomic technology and computer technology (Montague, 1989). Over 100 years have passed since Mendel published his original work on genetics in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8589c1bfdf10f2f11ee26a5c6b1a7d20
https://doi.org/10.1007/978-1-4899-2329-5_8
https://doi.org/10.1007/978-1-4899-2329-5_8
Autor:
William Gruber, Xiao-Jian Zhou, Gail J. Demmler, Robert F. Pass, John M. Trang, Mark Shelton, Richard J. Whitley, Bill Britt, Peter Reuman, Jean-Pierre Sommadossi, Stuart P. Adler, Richard F. Jacobs
Publikováno v:
Clinical Pharmacology & Therapeutics. 59:184-184
The population pharmacokinetics of ganciclovir was investigated in a group of 27 newborns with symptomatic congenital cytomegalovirus infection by nonlinear mixed-effects modeling analysis. Individual characteristicsincludingapproximatedcreatininecle