Zobrazeno 1 - 9
of 9
pro vyhledávání: '"John M. Stavorski"'
Autor:
A. Scriabine, John M. Stavorski
Publikováno v:
European Journal of Pharmacology. 42:63-69
Clonidine reduced cardiac acceleration induced by low frequency eletrical stimulation of cardiac symphathetic nerve fibers in anesthetized and vagotomized dogs. This effect of clonidine was abolished by short periods of high frequency electrical stim
Autor:
Robert G. Pendleton, John M. Stavorski
Publikováno v:
Drug Development Research. 6:363-370
Indomethacin was studied for its effects on three indices of gastric mucosal integrity in anesthetized cats. Following intragastric administration of the compound under conditions of constant stomach acidity and electrolyte concentrations, the transg
Autor:
Pfister Karl, Gaines Walter A, Katherine L. Meckelnberg, Clement A. Stone, Reinhold Donald F, Heinz. Arnold, William V Ruyle, Stein Gustav A, M. L. Torchiana, John M. Stavorski, Meyer Sletzinger
Publikováno v:
Journal of Medicinal and Pharmaceutical Chemistry. 5:665-690
Publikováno v:
Experientia. 35:653-655
2 new 4-trifluoromethylimidazole derivatives were found which lowered mean arterial pressure in renal and spontaneously hypertensive (SH) rats by the oral route. In SH rats, compounds A and B were 0.1 and 0.3 times, respectively, as potent as hydrala
Autor:
Charles S. Sweet, Herbert C. Wenger, Neeti R. Bohidar, C. T. Ludden, A. Scriabine, John M. Stavorski
Publikováno v:
European journal of pharmacology. 43(4)
St-91, 2(2,6-diethylphenylamino)-2-imidazoline ∗∗ , is a clonidine derivative which does not penetrate the blood-brain barrier. In spontaneously hypertensive (SH) rats is acutely increased arterial pressure and reduced heart rate while at 8 to 12
Publikováno v:
European journal of pharmacology. 123(1)
The effects of leukotrienes on gastric mucosal function in vivo, and on acid and pepsin secretion in vitro were investigated. In cats, treatment with leukotrienes C4 (LTC4), D4 (LTD4), and E4 (LTE4) caused significant decreases in the transgastric el
Autor:
Walfred S. Saari, Edward L. Engelhardt, Zell Hc, Stone Ca, Marcia E. Christy, Ludden Ct, John M. Stavorski, Colton Cd, Wenger Hc
Publikováno v:
Journal of medicinal chemistry. 8(6)
Publikováno v:
European journal of pharmacology. 14(4)
In anesthetized dogs germine-3-monoacetate (GMA), 40 to 640 μg/kg i.v., increased mean arterial pressure, right ventricular contractile force, left ventricular pressure and left ventricular dp/dt max. At 160 μg/kg i.v., GMA slightly increased the h
Autor:
A. Scriabine, John M. Stavorski
Publikováno v:
European journal of pharmacology. 24(1)
In anesthetized dogs, clonidine, 3, 10 and 30 μg/kg, i.v., antagonized cardiac acceleration induced by electrical stimulation of right post-ganglionic sympathetic fibers. In dogs with vagi intact, the effect of clonidine was not dependent on the fre