Zobrazeno 1 - 10
of 58
pro vyhledávání: '"John M. Stafford"'
Autor:
Lin Zhu, Julia An, Thao Luu, Sara M. Reyna, Puntip Tantiwong, Apiradee Sriwijitkamol, Nicolas Musi, John M. Stafford
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
IntroductionHigh density lipoproteins (HDL) exert cardiovascular protection in part through their antioxidant capacity and cholesterol efflux function. Effects of exercise training on HDL function are yet to be well established, while impact on triac
Externí odkaz:
https://doaj.org/article/88565ec9845944d587551b17651b4618
Autor:
Adriana C. Norris, Eugenia M. Yazlovitskaya, Lin Zhu, Bailey S. Rose, Jody C. May, Katherine N. Gibson-Corley, John A. McLean, John M. Stafford, Todd R. Graham
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Genetic association studies have linked ATP10A and closely related type IV P-type ATPases (P4-ATPases) to insulin resistance and vascular complications, such as atherosclerosis. ATP10A translocates phosphatidylcholine and glucosylceramide ac
Externí odkaz:
https://doaj.org/article/deaa33da942b4706af48c6856d33d349
Autor:
Lin Zhu, Bridget Litts, Yu Wang, Jeffrey A. Rein, Cassandra L. Atzrodt, Sivaprakasam Chinnarasu, Julia An, Ariel S. Thorson, Yaomin Xu, John M. Stafford
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101932- (2024)
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common complication of obesity and, in severe cases, progresses to metabolic dysfunction-associated steatohepatitis (MASH). Small heterodimer partner (SHP) is an orphan
Externí odkaz:
https://doaj.org/article/135bee091a7a4ee798034ba67244a454
Autor:
Adriana C. Norris, Eugenia M. Yazlovitskaya, Tzushan Sharon Yang, Alex Mansueto, John M. Stafford, Todd R. Graham
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Over 8% of couples worldwide are affected by infertility and nearly half of these cases are due to male-specific issues where the underlying cause is often unknown. Therefore, discovery of new genetic factors contributing to male-specific infertility
Externí odkaz:
https://doaj.org/article/c7f64f44adc947cc93b34f6290620bee
Autor:
Lin Zhu, Julia An, Sivaprakasam Chinnarasu, Thao Luu, Yasminye D. Pettway, Kelly Fahey, Bridget Litts, Hye-Young H. Kim, Charles R. Flynn, MacRae F. Linton, John M. Stafford
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Mounting evidence has shown that CETP has important physiological roles in adapting to chronic nutrient excess, specifically, to protect against diet-induced insulin resistance. However, the underlying mechanisms for the protective roles of CETP in m
Externí odkaz:
https://doaj.org/article/d13b563333c6492787d6d4eb6f12ac44
Publikováno v:
Physiological Reports, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract Elevated triglycerides (TGs) and impaired TG clearance increase the risk of cardiovascular disease in both men and women, but molecular mechanisms remain poorly understood. Cholesteryl ester transfer protein (CETP) is a lipid shuttling prote
Externí odkaz:
https://doaj.org/article/ce4569dc61aa4e86acc526337b4f22af
Publikováno v:
Molecular Metabolism, Vol 15, Iss , Pp 45-55 (2018)
Background: Endogenous sex hormones are important for metabolic health in men and women. Before menopause, women are protected from atherosclerotic cardiovascular disease (ASCVD) relative to men. Women have fewer cardiovascular complications of obesi
Externí odkaz:
https://doaj.org/article/706fafb1baf74a21a7e8f4de489933c6
Autor:
Lin Zhu, Jeanne Shi, Thao N. Luu, Joshua C. Neuman, Elijah Trefts, Sophia Yu, Brian T. Palmisano, David H. Wasserman, MacRae F. Linton, John M. Stafford
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 106-116 (2018)
Objective: Hepatocyte deletion of estrogen receptor alpha (LKO-ERα) worsens fatty liver, dyslipidemia, and insulin resistance in high-fat diet fed female mice. However, whether or not hepatocyte ERα regulates reverse cholesterol transport (RCT) in
Externí odkaz:
https://doaj.org/article/280e1ee22eac4ce5bbf61622a910d72b
Autor:
Brian T. Palmisano, Lin Zhu, Bridget Litts, Andreanna Burman, Sophia Yu, Joshua C. Neuman, Uche Anozie, Thao N. Luu, Emery M. Edington, John M. Stafford
Publikováno v:
Metabolites, Vol 11, Iss 5, p 330 (2021)
Mechanisms of sex differences in hypertriglyceridemia remain poorly understood. Small heterodimer partner (SHP) is a nuclear receptor that regulates bile acid, glucose, and lipid metabolism. SHP also regulates transcriptional activity of sex hormone
Externí odkaz:
https://doaj.org/article/0dabcd93f1b04e9aaee70835e6a8ce19
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 8, Pp 1541-1551 (2016)
Elevated plasma TGs increase risk of cardiovascular disease in women. Estrogen treatment raises plasma TGs in women, but molecular mechanisms remain poorly understood. Here we explore the role of cholesteryl ester transfer protein (CETP) in the regul
Externí odkaz:
https://doaj.org/article/cea0562813e443f99b006bc81a58b4c7