Zobrazeno 1 - 8
of 8
pro vyhledávání: '"John M. Sondey"'
Autor:
George D. Hartman, Pierre Mallorga, Michael F. Sugrue, Wasyl Halczenko, John M. Sondey, Harvey Schwam, Stuart R. Michelson, Robert L. Smith, W. C. Randall
Publikováno v:
Journal of Medicinal Chemistry. 35:3822-3831
A series of 4-substituted thiophene- and furan-2-sulfonamides was prepared and was found to possess nanomolar-level potency for inhibition of human carbonic anhydrase II in vitro. Selected examples from this group were further evaluated for their pot
Autor:
Anthony M. Smith, Michelson, Samuel L. Graham, Scholz Th, K. M. Strohmaier, Hudcosky Rj, Robert L. Smith, John M. Sondey, Harvey Schwam, Kenneth L. Shepard
Publikováno v:
Journal of Medicinal Chemistry. 34:3098-3105
For several decades a tantalizing goal for the treatment of primary open-angle glaucoma has been the development of a topically active carbonic anhydrase inhibitor. Recent results from several research groups indicate that considerable progress has b
Autor:
Harvey Schwam, John M. Sondey, Robert L. Smith, B. M. Mckeever, Michelson, James P. Springer, Pierre Mallorga, Murcko Mark A, George D. Hartman, John D. Prugh
Publikováno v:
Journal of Medicinal Chemistry. 34:1805-1818
A series of 5-substituted thieno[2,3-b]- and thieno[3,2-b)- and thieno[3,2-b)thiophene-2-sulfonamides was prepared and evaluated for topical ocular hypotensive activity in glaucoma models. The 5-substituents were varied to maximize both inhibitory po
Autor:
Robert L. Smith, Samuel L. Graham, Michelson, Jacob M. Hoffman, P. Gautheron, John M. Sondey, Scholz Th, Anthony M. Smith, Kenneth L. Shepard, Harvey Schwam
Publikováno v:
Journal of Medicinal Chemistry. 33:749-754
Derivatives of benzofuran- and indole-2-sulfonamide were prepared for evaluation as topically active ocular hypotensive agents. These compounds were found to be excellent inhibitors of carbonic anhydrase and to lower intraocular pressure in a rabbit
Autor:
Samuel Graham, Wayne J. Thompson, W. C. Randall, Pierre Mallorga, Scholz Th, Michael F. Sugrue, John M. Sondey, Harvey Schwam
Publikováno v:
Journal of medicinal chemistry. 36(15)
A series of sulfonylmethanesulfonamide derivatives is described, which are inhibitors of carbonic anhydrase (CA). The most potent of these is the racemic fluoro sulfone 9, which inhibits carbon dioxide hydration catalyzed by human CA II (CA-II) with
Autor:
John D. Prugh, Robert L. Smith, W. C. Randall, Harvey Schwam, Michael F. Sugrue, Stuart R. Michelson, John M. Sondey, Pierre Mallorga, Wasyl Halczenko, George D. Hartman
Publikováno v:
Journal of medicinal chemistry. 35(16)
Novel 5-[(alkylamino)methyl]thieno[2,3-b]furan-2-sulfonamides were prepared and evaluated in vitro for inhibition of human carbonic anhydrase II (CA II) and ex vivo for their ability to inhibit Ca II in the albino rabbit eye after topical administrat
Publikováno v:
Biochemistry. 17:1328-1337
The determination of the amino acid sequence of the enzyme dihydrofolate reductase (5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3) from a mutant of Escherichia coli B is described. The 159 residues were positioned by automatic Edman degra
Publikováno v:
Biochemistry. 18:2828-2833