Zobrazeno 1 - 10
of 182
pro vyhledávání: '"John M. Shannon"'
Autor:
Lu Han, Praneet Chaturvedi, Keishi Kishimoto, Hiroyuki Koike, Talia Nasr, Kentaro Iwasawa, Kirsten Giesbrecht, Phillip C. Witcher, Alexandra Eicher, Lauren Haines, Yarim Lee, John M. Shannon, Mitsuru Morimoto, James M. Wells, Takanori Takebe, Aaron M. Zorn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The fetal murine foregut develops into visceral organs via interactions between the mesoderm and endoderm, but how is unclear. Here, the authors use single cell RNAseq to show a diversity in organ specific splanchnic mesoderm cell-types, infer a sign
Externí odkaz:
https://doaj.org/article/0ee51be150a74c26a536081300641197
Autor:
Laertis Ikonomou, Michael J. Herriges, Sara L. Lewandowski, Robert Marsland, Carlos Villacorta-Martin, Ignacio S. Caballero, David B. Frank, Reeti M. Sanghrajka, Keri Dame, Maciej M. Kańduła, Julia Hicks-Berthet, Matthew L. Lawton, Constantina Christodoulou, Attila J. Fabian, Eric Kolaczyk, Xaralabos Varelas, Edward E. Morrisey, John M. Shannon, Pankaj Mehta, Darrell N. Kotton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The identity of the earliest murine in vivo lung epithelial progenitors (marked by NKX2-1 expression) is unclear. Here, the authors use single-cell RNA sequencing to define the genetic program of these lung primordial progenitors, which will improve
Externí odkaz:
https://doaj.org/article/3fb65185b9414530bfbace794788404c
Autor:
Talia Nasr, Andrea M. Holderbaum, Praneet Chaturvedi, Kunal Agarwal, Jessica L. Kinney, Keziah Daniels, Stephen L. Trisno, Vladimir Ustiyan, John M. Shannon, James M. Wells, Debora Sinner, Vladimir V. Kalinichenko, Aaron M. Zorn
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are
Externí odkaz:
https://doaj.org/article/22d587f58b184e8ba68ff0e088f3e21b
Autor:
Scott A. Rankin, Lu Han, Kyle W. McCracken, Alan P. Kenny, Christopher T. Anglin, Emily A. Grigg, Calyn M. Crawford, James M. Wells, John M. Shannon, Aaron M. Zorn
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 66-78 (2016)
Organogenesis of the trachea and lungs requires a complex series of mesoderm-endoderm interactions mediated by WNT, BMP, retinoic acid (RA), and hedgehog (Hh), but how these pathways interact in a gene regulatory network is less clear. Using Xenopus
Externí odkaz:
https://doaj.org/article/9c4e2dee78e04be7a6e7b6e8d913ce0e
Autor:
Keziah Daniels, Vladimir Ustiyan, James M. Wells, Debora Sinner, Stephen L. Trisno, Jessica L. Kinney, John M. Shannon, Vladimir V. Kalinichenko, Kunal Agarwal, Andrea M. Holderbaum, Praneet Chaturvedi, Talia Nasr, Aaron M. Zorn
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms
article-version (VoR) Version of Record
Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are
Autor:
Takanori Takebe, Keishi Kishimoto, Talia Nasr, Lauren Haines, Phillip C. Witcher, Hiroyuki Koike, Mitsuru Morimoto, Kirsten Giesbrecht, Lu Han, Aaron M. Zorn, Yarim Lee, John M. Shannon, James M. Wells, Alexandra Eicher, Praneet Chaturvedi, Kentaro Iwasawa
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Visceral organs, such as the lungs, stomach and liver, are derived from the fetal foregut through a series of inductive interactions between the definitive endoderm (DE) and the surrounding splanchnic mesoderm (SM). While DE patterning is fairly well
Autor:
Stephen L. Trisno, Talia Nasr, Aaron M. Zorn, Keziah Daniels, Vladimir V. Kalinichenko, Praneet Chaturvedi, John M. Shannon, James M. Wells, Kunal Agarwal, Jessica L. Kinney, Vladimir Ustiyan, Debora Sinner
Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35ffa2175c500e914ca9b94c9e99df81
https://doi.org/10.1101/2020.07.11.198556
https://doi.org/10.1101/2020.07.11.198556
Autor:
Jeffrey E. Gotts, Dong-Kee Lee, Ying Wei, Ying Xi, Thomas J. Kim, Jianming Xu, Harold A. Chapman, Michael A. Matthay, Victor M. Tan, Andrew E. Vaughan, John M. Shannon, Ian Driver, Julia R. Jackson, Alexis N. Brumwell
Publikováno v:
Nature cell biology
Nature cell biology, vol 19, iss 8
Nature cell biology, vol 19, iss 8
After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar ty
Publikováno v:
Developmental Biology. 427:93-105
Crosstalk between mesenchymal and epithelial cells influences organogenesis in multiple tissues, such as lung, pancreas, liver, and the nervous system. Lung mesenchyme comprises multiple cell types, however, and precise identification of the mesenchy
Autor:
Darrell N. Kotton, Brian R. Davis, Brandon G. Wong, Finn Hawkins, Anthony N. Hollenberg, Katherine B. McCauley, Sarah X.L. Huang, Nicholas Skvir, Jason R. Rock, Dylan C. Thomas, Sinead Nguyen, Anita A. Kurmann, Philipp Kramer, Ahmad S. Khalil, John M. Shannon, Ian Driver, Ana M. Crane, Anjali Jacob, Susan H. Guttentag
Publikováno v:
Journal of Clinical Investigation. 127:2277-2294
It has been postulated that during human fetal development, all cells of the lung epithelium derive from embryonic, endodermal, NK2 homeobox 1–expressing (NKX2-1+) precursor cells. However, this hypothesis has not been formally tested owing to an i