Zobrazeno 1 - 10
of 11
pro vyhledávání: '"John M. Saathoff"'
Autor:
John M. Saathoff, Kai Liu, Jeremy E. Chojnacki, Liu He, Qun Chen, Edward J. Lesnefsky, Shijun Zhang
Publikováno v:
Molecules, Vol 21, Iss 4, p 412 (2016)
We have recently developed a bivalent strategy to provide novel compounds that potentially target multiple risk factors involved in the development of Alzheimer’s disease (AD). Our previous studies employing a bivalent compound with a shorter space
Externí odkaz:
https://doaj.org/article/1db1d823b7944daa8f51870c7e3b6df2
Publikováno v:
Bioorg Med Chem Lett
In our continuing efforts to develop novel neuroprotectants for Alzheimer’s disease (AD), a series of analogs based on a lead compound that was recently shown to target the mitochondrial complex I were designed, synthesized and biologically charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fadc54243b9fb5a2f8362d3b4ef201
https://doi.org/10.1016/j.bmcl.2021.128081
https://doi.org/10.1016/j.bmcl.2021.128081
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:7324-7331
In an effort to combat the multifaceted nature of Alzheimer's disease (AD) progression, a series of multifunctional, bivalent compounds containing curcumin and diosgenin were designed, synthesized, and biologically characterized. Screening results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3106dfebaaa0cbbb88878992db2f2c64
https://doi.org/10.1016/j.bmc.2015.10.032
https://doi.org/10.1016/j.bmc.2015.10.032
Autor:
John M. Saathoff, Jeremy E. Chojnacki, Emily E. Wade, Qun Chen, Kai Liu, Edward J. Lesnefsky, Shijun Zhang
Publikováno v:
Journal of Alzheimer's Disease. 47:1021-1033
Multiple pathogenic factors have been suggested in playing a role in the development of Alzheimer’s disease (AD). The multifactorial nature of AD also suggests the potential use of compounds with polypharmacology as effective disease-modifying agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fd1c10b1f8c60a3c06adfe2a631d2e
https://doi.org/10.3233/jad-150242
https://doi.org/10.3233/jad-150242
Autor:
Pablo Martinez-Martin, Gorka Gerenu, Xiongwei Zhu, Kai Liu, Shijun Zhang, George Perry, John M. Saathoff, Hyoung Gon Lee, Jeremy E. Chojnacki
Publikováno v:
ACS Chemical Neuroscience. 6:1393-1399
In our efforts to develop hybrid compounds of curcumin and melatonin as potential disease-modifying agents for Alzheimer’s disease (AD), a potent lead hybrid compound, Z-CM-I-1, has been recently identified and biologically characterized in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedbc9b48a594c5326fb77c299533e91
https://doi.org/10.1021/acschemneuro.5b00082
https://doi.org/10.1021/acschemneuro.5b00082
Autor:
Luca Agnetta, Maria Laura Bolognesi, Salvatore Bongarzone, Giovanni Bottegoni, María do Carmo Carreiras, Andrea Cavalli, Kelly Chibale, Michael Decker, Dominik Dolles, John F. Gilmer, Liu He, Guozheng Huang, Lhassane Ismaili, José Marco-Contelles, Diego Muñoz-Torrero, Peter Mbugua Njogu, John Okombo, Federica Prati, Alejandro Romero, John M. Saathoff, Elisa Uliassi, Shijun Zhang, Qingjie Zhao
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5677f55d1c838fea5d9b976a5938be20
https://doi.org/10.1016/b978-0-08-101011-2.00016-7
https://doi.org/10.1016/b978-0-08-101011-2.00016-7
The pipeline in drug discovery for diseases with complex pathogenic factors has been facing significant challenges recently since the traditional “one molecule, one target” drug discovery paradigm is not adequately addressing many diseases. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51f3083c404b673eb82831e38a6feef4
https://doi.org/10.1016/b978-0-08-101011-2.00008-8
https://doi.org/10.1016/b978-0-08-101011-2.00008-8
Autor:
Liu He, Jeremy E. Chojnacki, Kai Liu, John M. Saathoff, Edward J. Lesnefsky, Qun Chen, Shijun Zhang
Publikováno v:
Molecules, Vol 21, Iss 4, p 412 (2016)
Molecules (Basel, Switzerland)
Molecules; Volume 21; Issue 4; Pages: 412
Molecules (Basel, Switzerland)
Molecules; Volume 21; Issue 4; Pages: 412
We have recently developed a bivalent strategy to provide novel compounds that potentially target multiple risk factors involved in the development of Alzheimer's disease (AD). Our previous studies employing a bivalent compound with a shorter spacer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cb0d61c421ace40069b233c8e7477c
http://www.mdpi.com/1420-3049/21/4/412
http://www.mdpi.com/1420-3049/21/4/412
Publikováno v:
Alzheimer's & Dementia. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec23327fb97ebfc611a92123cd8acd1e
https://doi.org/10.1016/j.jalz.2015.06.1877
https://doi.org/10.1016/j.jalz.2015.06.1877
Publikováno v:
Alzheimer's & Dementia. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e4d66ebd6efedbe919bcea982f875c7
https://doi.org/10.1016/j.jalz.2015.06.520
https://doi.org/10.1016/j.jalz.2015.06.520