GLUT3/SLC2A3 Is an Endogenous Marker of Hypoxia in Prostate Cancer Cell Lines and Patient-Derived Xenograft Tumors

Autor: John M. Ryniawec, Matthew R. Coope, Emily Loertscher, Vignesh Bageerathan, Diogo de Oliveira Pessoa, Noel A. Warfel, Anne E. Cress, Megha Padi, Gregory C. Rogers

Publikováno v: Diagnostics, Vol 12, Iss 3, p 676 (2022)

The microenvironment of solid tumors is dynamic and frequently contains pockets of low oxygen levels (hypoxia) surrounded by oxygenated tissue. Indeed, a compromised vasculature is a hallmark of the tumor microenvironment, creating both spatial gradi

Externí odkaz: https://doaj.org/article/c4e1e61df9ed433b88d558f67f31cb13

A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4

Autor: Brian J. Galletta, Carey J. Fagerstrom, Todd A. Schoborg, Tiffany A. McLamarrah, John M. Ryniawec, Daniel W. Buster, Kevin C. Slep, Gregory C. Rogers, Nasser M. Rusan

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

The centrosome is a large intracellular structure that serves as the microtubule-organising center, but how it is accurately assembled is not known. Here the authors generate a ‘domain-level’ centrosome interactome and show that Plk4 positions th

Externí odkaz: https://doaj.org/article/bd602ba043d3456eb55d85545a7af134

Polo-like kinase 4 homodimerization is not required for catalytic activation, autodestruction, or centriole assembly

Autor: Kevin C. Slep, Cody J. Boese, Anastasia Amoiroglou, Lauren K. Slevin, Spencer Dean, John M. Ryniawec, Gregory C. Rogers, Daniel W. Buster

Polo-like kinase 4 (Plk4) is the master-regulator of centriole assembly and cell cycle-dependent regulation of its activity maintains proper centrosome number. During most of the cell cycle, Plk4 levels are nearly undetectable due to its ability to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ce93cb21af899ac63b910c1724da171
https://doi.org/10.1101/2021.11.15.468682

Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells

Autor: Anthony Simon, Yuu Kimata, Maddalena Nano, Victor Racine, Daniel W. Buster, Alix Goupil, John M. Ryniawec, Carole Pennetier, Davide Gambarotto, Renata Basto, Delphine Gogendeau, Gregory C. Rogers, Damien Blanc

Publikováno v: Developmental Cell
Developmental Cell, Elsevier, 2019, 50, pp.11-24.e10. ⟨10.1016/j.devcel.2019.04.036⟩
Developmental Cell, Elsevier, 2019, 50 (1), pp.11-24.e10. ⟨10.1016/j.devcel.2019.04.036⟩

Summary Defects in mitotic spindle orientation (MSO) disrupt the organization of stem cell niches impacting tissue morphogenesis and homeostasis. Mutations in centrosome genes reduce MSO fidelity, leading to tissue dysplasia and causing several disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c652fcb130fbd30e59f665da1f99a21b
https://hal.archives-ouvertes.fr/hal-03454910

A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4

Autor: John M. Ryniawec, Daniel W. Buster, Tiffany A. McLamarrah, Gregory C. Rogers, Nasser M. Rusan, Carey J. Fagerstrom, Kevin C. Slep, Brian J. Galletta, Todd A. Schoborg

Publikováno v: Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

The centrosome is the major microtubule-organizing centre of many cells, best known for its role in mitotic spindle organization. How the proteins of the centrosome are accurately assembled to carry out its many functions remains poorly understood. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718aba7b3b770768603cf8ff2bfa6c0b
https://doi.org/10.1038/ncomms12476