Accelerated sonothrombolysis with Definity in a xenographic porcine cerebral thromboembolism model

Autor: Robert T. Kleven, Kunal B. Karani, Nicole Hilvert, Samantha M. Ford, Karla P. Mercado-Shekhar, John M. Racadio, Marepalli B. Rao, Todd A. Abruzzo, Christy K. Holland

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Adjuvant ultrasound at 2 MHz with or without an ultrasound contrast agent improves the rate of thrombus resolution by recombinant tissue plasminogen activator (rt-PA) in laboratory and clinical studies. A sub-megahertz approach can further e

Externí odkaz: https://doaj.org/article/194cf381637f4fa18334d3a7647f19d8

Isolated Upper Extremity Posttransplant Lymphoproliferative Disorder in a Child

Autor: Sarah E. Halula, Daniel G. Leino, Manish N. Patel, John M. Racadio, Matthew P. Lungren

Publikováno v: Case Reports in Radiology, Vol 2015 (2015)

Posttransplant lymphoproliferative disorder (PTLD) is a well-described complication of solid organ and bone marrow transplants. The most common presentation is intra-abdominal lymphadenopathy or single or multiple intraparenchymal masses involving th

Externí odkaz: https://doaj.org/article/ffbc022b5ecd48c9811c6e6e19e7460e

Data from Intratumoral Injection of HSV1716, an Oncolytic Herpes Virus, Is Safe and Shows Evidence of Immune Response and Viral Replication in Young Cancer Patients

Autor: Timothy P. Cripe, Joe Conner, Robert Spavin, Kathleen Simpson, Marianne Brunner, Beth Stockman, Lori R. Backus, Devon J. Dishman, Kristy Ott-Napier, Melinda Triplet, Michele R. Vaughan, Alexander J. Towbin, John M. Racadio, Patrick S. Warren, Mark A. Currier, James I. Geller, Keri A. Streby

Purpose: HSV1716 is an oncolytic herpes simplex virus-1 (HSV-1) studied in adults via injection into the brain and superficial tumors. To determine the safety of administering HSV1716 to pediatric patients with cancer, we conducted a phase I trial of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c03d81186256f1fe1e3d21f5dfaed99
https://doi.org/10.1158/1078-0432.c.6526407.v1

Effect of Thrombin and Incubation Time on Porcine Whole Blood Clot Elasticity and Recombinant Tissue Plasminogen Activator Susceptibility

Autor: Chadi Zemzemi, Matthew Phillips, Deborah C. Vela, Nicole A. Hilvert, John M. Racadio, Kenneth B. Bader, Kevin J. Haworth, Christy K. Holland

Publikováno v: Ultrasound in medicinebiology. 48(8)

Deep vein thrombosis is a major source of morbidity and mortality worldwide. Catheter-directed thrombolytics are the frontline approach for vessel recanalization, though fibrinolytic efficacy is limited for stiff, chronic thrombi. Although thrombin h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e123868047a22cdba83b6c69e09be1
https://pubmed.ncbi.nlm.nih.gov/35644763

Diffuse reflectance spectroscopy for breach detection during pedicle screw placement: a first in vivo investigation in a porcine model

Autor: Joanneke Groen, Jarich W. Spliethoff, John M. Racadio, Erik Edström, Benno H. W. Hendriks, Jenny Dankelman, Akash Swamy, Gustav Burström, Adrian Elmi-Terander, Drazenko Babic, Christian Reich

Publikováno v: BioMedical Engineering
BioMedical Engineering OnLine, 19(1)
Biomedical engineering online, 19(1):47. BioMed Central
BioMedical Engineering OnLine, Vol 19, Iss 1, Pp 1-12 (2020)

Background The safe and accurate placement of pedicle screws remains a critical step in open and minimally invasive spine surgery, emphasizing the need for intraoperative guidance techniques. Diffuse reflectance spectroscopy (DRS) is an optical sensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa79f6a57efacc891be71f8c6635cfd
https://pubmed.ncbi.nlm.nih.gov/32532305