Zobrazeno 1 - 10
of 53
pro vyhledávání: '"John M. Ong"'
Autor:
Lily E. Kisia, Qiuying Cheng, Evans Raballah, Elly O. Munde, Benjamin H. McMahon, Nick W. Hengartner, John M. Ong’echa, Kiprotich Chelimo, Christophe G. Lambert, Collins Ouma, Prakasha Kempaiah, Douglas J. Perkins, Kristan A. Schneider, Samuel B. Anyona
Publikováno v:
Tropical Medicine and Health, Vol 50, Iss 1, Pp 1-15 (2022)
Abstract Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte–macrophage colony-
Externí odkaz:
https://doaj.org/article/9181a3a765424ab5950663800c7efad4
Autor:
Jinwei Hu, Bindu Konda, John M. Ong, Norihiko Kawamata, Dong Yin, Keith L. Black, H. Phillip Koeffler, Julian C. Desmond
Publikováno v:
Clinical Cancer Research. 13:1045-1052
Purpose: Histone acetylation is one of the main mechanisms involved in regulation of gene expression. During carcinogenesis, tumor-suppressor genes can be silenced by aberrant histone deacetylation. This epigenetic modification has become an importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79376474312666c9b2e380d10fc592d
https://doi.org/10.1158/1078-0432.ccr-06-1261
https://doi.org/10.1158/1078-0432.ccr-06-1261
Autor:
Keith L. Black, John S. Yu, Sebastian Wachsmann-Hogiu, John M. Ong, Jinwei Hu, Daniel L. Farkas, Maria Laura Belladonna, Xiangpeng Yuan
Publikováno v:
Cancer Research. 66:8887-8896
Dendritic cells (DCs) are potent antigen-presenting cells that play a critical role in priming immune responses to tumor. Interleukin (IL)-23 can act directly on DC to promote immunogenic presentation of tumor peptide in vitro. Here, we evaluated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268b30dd860c2db842704f065000e7a3
https://doi.org/10.1158/0008-5472.can-05-3448
https://doi.org/10.1158/0008-5472.can-05-3448
Autor:
Takashi Kumagai, John M. Ong, Hong Zhou, Dong Yin, H. Phillip Koeffler, Keith L. Black, Gentao Liu
Publikováno v:
Oncogene. 24:344-354
The proteasome plays a pivotal role in controlling cell proliferation, apoptosis, and differentiation in a variety of normal and tumor cells. PS-341, a novel boronic acid dipeptide that inhibits 26S proteasome activity, has prominent effects in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a57275ca334343e9dede03370dbe9c
https://doi.org/10.1038/sj.onc.1208225
https://doi.org/10.1038/sj.onc.1208225
Autor:
Gail M. Seigel, Ingrid Sacerio, Anthony B. Nesburn, Raquel Castellon, M. Cristina Kenney, Annette M. Aoki, John M. Ong
Publikováno v:
Neurochemical Research. 28:883-891
Studies have shown an intimate relationship between cholesterol and retinal diseases; we examined the effects of cholesterol oxides on cultured cells. Using the rat retinal precursor cell line R28 and the human RPE cell line ARPE-19, we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b34d34cc7d333bdd26711c857ab52167
https://doi.org/10.1023/a:1023223409798
https://doi.org/10.1023/a:1023223409798
Autor:
Anthony B. Nesburn, M. Cristina Kenney, Jacob Reznik, Raquel Castellon, David S. Boyer, Shari R. Atilano, Kent W. Small, Nitin Udar, John M. Ong, Jeffrey H Tavis, Annette M. Aoki, Donald J. Brown, Hamdi K. Hamdi
Publikováno v:
Biochemical and Biophysical Research Communications. 295:668-672
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. We report an association between an Alu polymorphism in the angiotensin-converting enzyme (ACE) gene with the dry/atrophic form of AMD. Using the polymerase chai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6a7619ad78044ba2dcfa4a1120e7b4
https://doi.org/10.1016/s0006-291x(02)00728-3
https://doi.org/10.1016/s0006-291x(02)00728-3
Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in Kenyan children with endemic Burkitt lymphoma
Autor:
Beatrice M. Muriuki, Catherine S. Forconi, Erastus K. Kirwa, Titus K. Maina, Bonface O. Ariera, Jeffrey A. Bailey, Anita Ghansah, Ann M. Moormann, John M. Ong’echa
Publikováno v:
PLoS ONE, Vol 18, Iss 8 (2023)
Endemic Burkitt lymphoma (eBL) is a fast-growing germinal center B cell lymphoma, affecting 5–10 per 100,000 children annually, in the equatorial belt of Africa. We hypothesize that co-infections with Plasmodium falciparum (Pf) malaria and Epstein-
Externí odkaz:
https://doaj.org/article/bbd6fd04cb4e43f8a84fda999cea8ab6
Publikováno v:
Journal of Clinical Investigation. 97:1111-1116
TNFalpha is orverexpressed in the adipose tissue of obese rodents and humans, and is associated with insulin resistance. To more closely link TNF expression with whole body insulin action, we examined the expression of TNF by muscle, which is respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da22bad6b32cd808a29962a7d89ef7ce
https://doi.org/10.1172/jci118504
https://doi.org/10.1172/jci118504
Publikováno v:
Journal of Clinical Investigation. 96:2438-2444
Lipoprotein lipase (LPL) is a central enzyme in lipoprotein metabolism and is in part responsible for adipocyte lipid accumulation. Catecholamines are known to decrease the activity of LPL in adipocytes, and we have previously demonstrated that this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7e235c2884bd00410c74059acad2ef
https://doi.org/10.1172/jci118301
https://doi.org/10.1172/jci118301
Publikováno v:
Journal of Clinical Investigation. 95:2111-2119
A previous study reported the increased expression of the cytokine TNF in the adipose tissue of genetically obese rodents. To examine this paradigm in humans, we studied TNF expression in lean, obese, and reduced-obese human subjects. TNF mRNA was de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a033d2fe404e3e0451d65a0451282f2c
https://doi.org/10.1172/jci117899
https://doi.org/10.1172/jci117899