Zobrazeno 1 - 10
of 19
pro vyhledávání: '"John M. Nicoludis"'
Autor:
Dawei Sun, Yonglian Sun, Eric Janezic, Tricia Zhou, Matthew Johnson, Caleigh Azumaya, Sigrid Noreng, Cecilia Chiu, Akiko Seki, Teresita L. Arenzana, John M. Nicoludis, Yongchang Shi, Baomei Wang, Hoangdung Ho, Prajakta Joshi, Christine Tam, Jian Payandeh, Laëtitia Comps-Agrar, Jianyong Wang, Sascha Rutz, James T. Koerber, Matthieu Masureel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The C-C motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has emerged as a promising therapeutic target in cancer. Targeting CCR8 with an antibody has appeared to be an attractive therapeutic approach, but the mo
Externí odkaz:
https://doaj.org/article/5b0eb640ac9a4c3d8b5a4451fd7cf224
Autor:
Aaron T Bozzi, Christina M Zimanyi, John M Nicoludis, Brandon K Lee, Casey H Zhang, Rachelle Gaudet
Publikováno v:
eLife, Vol 8 (2019)
Nramp family transporters—expressed in organisms from bacteria to humans—enable uptake of essential divalent transition metals via an alternating-access mechanism that also involves proton transport. We present high-resolution structures of Deino
Externí odkaz:
https://doaj.org/article/2ffaf0b83ca3479bb191db679e73d90c
Autor:
Huong T. Kratochvil, Laura C. Watkins, Marco Mravic, Noah H. Somberg, Jessica L. Thomaston, John M. Nicoludis, Lijun Liu, Mei Hong, Gregory A. Voth, William F. DeGrado
Summary paragraphSelective proton transport through proteins is essential for forming and utilizing proton gradients in cells. Protons are conducted along hydrogen-bonded “wires” of water molecules and polar sidechains, which, somewhat surprising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830086f39133300e46b1b95d02864691
https://doi.org/10.1101/2022.03.28.485852
https://doi.org/10.1101/2022.03.28.485852
Autor:
John M Nicoludis, Bennett E Vogt, Anna G Green, Charlotta PI Schärfe, Debora S Marks, Rachelle Gaudet
Publikováno v:
eLife, Vol 5 (2016)
Protocadherins (Pcdhs) are cell adhesion and signaling proteins used by neurons to develop and maintain neuronal networks, relying on trans homophilic interactions between their extracellular cadherin (EC) repeat domains. We present the structure of
Externí odkaz:
https://doaj.org/article/969b0c85b4b5405ea48a896dbd59b91d
Publikováno v:
Biophysical Journal. 121:325a
Autor:
John M. Nicoludis, Rachelle Gaudet
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1860:895-908
Recently, protein sequence coevolution analysis has matured into a predictive powerhouse for protein structure and function. Direct Coupling Analysis, a method that uses a global statistical model of sequence coevolution, has enabled the prediction o
Autor:
John M. Nicoludis, Anna G. Green, Rachelle Gaudet, Sanket Walujkar, Elizabeth May, Marcos Sotomayor, Debora S. Marks
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(36)
Clustered protocadherins, a large family of paralogous proteins that play important roles in neuronal development, provide an important case study of interaction specificity in a large eukaryotic protein family. A mammalian genome has more than 50 cl
Autor:
Christina M Zimanyi, Casey H Zhang, Aaron T. Bozzi, Brandon Lee, John M. Nicoludis, Rachelle Gaudet
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Nramp family transporters—expressed in organisms from bacteria to humans—enable uptake of essential divalent transition metals via an alternating-access mechanism that also involves proton transport. We present high-resolution structures of Deino
Autor:
Wilhelm A. Weihofen, John M. Nicoludis, Sze-Yi Lau, Debora S. Marks, Rachelle Gaudet, Charlotta P I Schärfe
Publikováno v:
Structure. 23:2087-2098
SummaryClustered protocadherin (Pcdh) proteins mediate dendritic self-avoidance in neurons via specific homophilic interactions in their extracellular cadherin (EC) domains. We determined crystal structures of EC1–EC3, containing the homophilic spe