Zobrazeno 1 - 10
of 22
pro vyhledávání: '"John M. Molyneaux"'
Autor:
Sandra W. Curtiss, D. Joseph Rogier, Alan MacInnes, Brown David L, Mike B. Tollefson, Brian R. Bond, Yvette M. Fobian, Maddux Todd Michael, Dafydd R. Owen, Jeanne M. Rumsey, Brent V. Mischke, Jerry W. Cubbage, Alan G. Benson, Robert Hughes, Lena L Zhang, E. Jon Jacobsen, Steven E. Heasley, Joseph B. Moon, Ying Yu, John M. Molyneaux, Yi Zheng, Brad A. Acker, Blevis-Bal Radhika M, John N. Freskos, John K. Walker, Jennie L. Walgren
Publikováno v:
Journal of Medicinal Chemistry. 53:2656-2660
We recently described a novel series of aminopyridopyrazinones as PDE5 inhibitors. Efforts toward optimization of this series culminated in the identification of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::892c7788c8aa398973abd4f8bb5a78a5
https://doi.org/10.1021/jm901781q
https://doi.org/10.1021/jm901781q
Autor:
Maddux Todd Michael, Yvette M. Fobian, Alan G. Benson, Dafydd R. Owen, Brian R. Bond, Christopher Phillips, Brad A. Acker, E. Jon Jacobsen, Michael John Palmer, D. Joseph Rogier, John M. Molyneaux, Brent V. Mischke, John N. Freskos, Tracy J. Ringer, Andrew Simon Bell, Blevis-Bal Radhika M, Robert Hughes, David G. Brown, Steve E. Heasley, Joseph B. Moon, John K. Walker, Brown David L, William C. Stallings, Michael B. Tollefson, Alan MacInnes, Jerry W. Cubbage, Yung Yu, Margarita Rodriquez-Lens, Fox David Nathan Abraham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4088-4091
A new class of potent and selective PDE5 inhibitors is disclosed. Guided by X-ray crystallographic data, optimization of an HTS lead led to the discovery of a series of 2-aryl, (N8)-alkyl substituted-6-aminosubstituted pyrido[3,2b]pyrazinones which s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5005db6742e606fdadbf520ea66a63a9
https://doi.org/10.1016/j.bmcl.2009.06.012
https://doi.org/10.1016/j.bmcl.2009.06.012
Autor:
John N. Freskos, Yvette M. Fobian, Timothy E. Benson, Michael J. Bienkowski, David L. Brown, Thomas L. Emmons, Robert Heintz, Alice Laborde, Joseph J. McDonald, Brent V. Mischke, John M. Molyneaux, Joseph B. Moon, Patrick B. Mullins, D. Bryan Prince, Donna J. Paddock, Alfredo G. Tomasselli, Gregory Winterrowd
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:73-77
We describe a novel series of potent inhibitors of human beta-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5A crystal structure of inhibitor 32 bound to BACE is provided.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e643373fd67faba63c23379fdd0447
https://doi.org/10.1016/j.bmcl.2006.09.092
https://doi.org/10.1016/j.bmcl.2006.09.092
Autor:
John M. Molyneaux, Jennifer L. Brace, Tim N. Oulmassov, James K. Bashkin, Stephen C. Winans, John C. Anderson, Paula C. Miller, Terina Pappas, Rongguang Zhang, Andrzej Joachimiak
Publikováno v:
Nature. 417:971-974
Many proteobacteria are able to monitor their population densities through the release of pheromones known as N-acylhomoserine lactones. At high population densities, these pheromones elicit diverse responses that include bioluminescence, biofilm for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955edd4adf1767bb7d9bc913ce492221
https://doi.org/10.1038/nature00833
https://doi.org/10.1038/nature00833
Autor:
James R. Kiefer, Barta Thomas E, Heintz Robert M, Yvette M. Fobian, Daniel P. Becker, Grace E. Munie, Patrick B. Mullins, John M. Molyneaux, Brent V. Mischke, Darren J. Kassab, Louis J. Bedell, John N. Freskos
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2823-2825
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64fc828c6eacfa443f80cdc71c9f154
https://doi.org/10.1016/j.bmcl.2011.03.095
https://doi.org/10.1016/j.bmcl.2011.03.095
Autor:
Paula C. Miller, John M. Molyneaux
Publikováno v:
Organic Preparations and Procedures International. 31:295-304
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1beaf8d86ab91205ad83043d483e039
https://doi.org/10.1080/00304949909458323
https://doi.org/10.1080/00304949909458323
Publikováno v:
Journal of Combinatorial Chemistry. 1:223-234
A solid-phase organic synthesis method has been developed for the preparation of 3-carboxypyrrolinones 9. Treatment of polymer-bound malonic acid with amino alcohols afforded the malonamide resin products 6. Benzyl and alkyl amino alcohols were prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ea7fa5a05c424de297128e81095deb3
https://doi.org/10.1021/cc990002j
https://doi.org/10.1021/cc990002j
Publikováno v:
ChemInform. 22
The title compounds 2, have now been shown to arise in certain cases from condensation of aromatic ortho-diesters with ketone, where formerly only indeno[1,2-c]pyrazol-4(1H)-ones 3 have been reported from such reaction. Heretofore 2 was obtained in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b49655b416711cb2b4ba0edec9e51ff
https://doi.org/10.1002/chin.199138075
https://doi.org/10.1002/chin.199138075
Autor:
J. E. Kaufmann, L. Y. L. Sing, Gina L. Stikes, John M. Molyneaux, John P. Chupp, S. K. Parrish, J. E. Normansell, L. F. Lee
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b985876ce3fd4ac3470f17df9133382
https://doi.org/10.1002/chin.199132296
https://doi.org/10.1002/chin.199132296
Autor:
John M. Molyneaux, Paula C. Miller
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c7bd856c4ea07669beee096f492dcfb
https://doi.org/10.1002/chin.199942182
https://doi.org/10.1002/chin.199942182