Výsledky vyhledávání - "John M. Mitchell"

Performance of Hair Testing for Cocaine Use—Comparison of Five Laboratories Using Blind Reference Specimens

Autor: E Dale Hart, Svante Vikingsson, Ruth E Winecker, Amy L Evans, Edward J Cone, John M Mitchell, Eugene D Hayes, Ronald R Flegel

Publikováno v: Journal of Analytical Toxicology. 47:154-161

The purpose of this study was to compare results from five commercial hair testing laboratories conducting workplace drug testing with regard to bias, precision, selectivity and decontamination efficiency. Nine blind hair specimens, including cocaine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d461e1319f692e38faf89e4409899a5
https://doi.org/10.1093/jat/bkac066

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Urinary Pharmacokinetic Profile of Cannabidiol (CBD), Δ9-Tetrahydrocannabinol (THC) and Their Metabolites following Oral and Vaporized CBD and Vaporized CBD-Dominant Cannabis Administration

Autor: Ruth E. Winecker, Elia Goffi, George E. Bigelow, Ryan Vandrey, John M. Mitchell, Ronald Flegel, Edward J. Cone, David J. Kuntz, Tory R. Spindle, Dennis J. Sholler

Publikováno v: J Anal Toxicol

The market for products containing cannabidiol (CBD) is booming globally. However, the pharmacokinetics of CBD in different oral formulations and the impact of CBD use on urine drug testing outcomes for cannabis (e.g., 11-nor-9-carboxy-Δ9-tetrahydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9a01ff2acb9ac19c9bc2d671d6c980
https://doi.org/10.1093/jat/bkab059

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Conversion of 7-Carboxy-Cannabidiol (7-COOH-CBD) to 11-Nor-9-Carboxy-Tetrahydrocannabinol (THC-COOH) during Sample Preparation for GC–MS Analysis

Autor: E Dale Hart, John M. Mitchell, Ronald Flegel, Ruth E. Winecker, Svante Vikingsson, Eugene D Hayes

Publikováno v: Journal of Analytical Toxicology. 46:573-576

The growing use of cannabidiol (CBD) products by the general public is expected to result in an increase in the prevalence of CBD and the CBD metabolites in drug testing laboratories. CBD converts into tetrahydrocannabinol (THC) under acid conditions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25f8acb5349991b85fb937caf00ab85
https://doi.org/10.1093/jat/bkab046

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Pharmacokinetic Profile of ∆9-Tetrahydrocannabinol, Cannabidiol and Metabolites in Blood following Vaporization and Oral Ingestion of Cannabidiol Products

Autor: Cecilia L Bergeria, Tory R Spindle, Edward J Cone, Dennis Sholler, Elia Goffi, John M Mitchell, Ruth E Winecker, George E Bigelow, Ronald Flegel, Ryan Vandrey

Publikováno v: J Anal Toxicol

There is limited data on the comparative pharmacokinetics of cannabidiol (CBD) across oral and vaporized formulations. This within-subject, double-blind, double-dummy, placebo-controlled laboratory study analyzed the pharmacokinetic profile of CBD, �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029d3fecfe9db7c274c97498f3ff46f6
https://pubmed.ncbi.nlm.nih.gov/35438179

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Pharmacokinetics of Cannabis Brownies: A Controlled Examination of Δ9-Tetrahydrocannabinol and Metabolites in Blood and Oral Fluid of Healthy Adult Males and Females

Autor: Ronald Flegel, George E. Bigelow, John M. Mitchell, Evan S. Herrmann, Ryan Vandrey, Tory R. Spindle, Edward J. Cone, Charles LoDico

Publikováno v: J Anal Toxicol

Oral cannabis products (a.k.a. “edibles”) have increased in popularity in recent years. Most prior controlled pharmacokinetic evaluations of cannabis have focused on smoked cannabis and included males who were frequent cannabis users. In this stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10bc2569faed54b15b6680e64f96973
https://pubmed.ncbi.nlm.nih.gov/32591782

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Pharmacokinetic Profile of Oral Cannabis in Humans: Blood and Oral Fluid Disposition and Relation to Pharmacodynamic Outcomes

Autor: Ronald Flegel, Edward J. Cone, Charles LoDico, John M. Mitchell, Ryan Vandrey, Evan S. Herrmann, George E. Bigelow

Publikováno v: Journal of Analytical Toxicology. 41:83-99

Most research on cannabis pharmacokinetics has evaluated inhaled cannabis, but oral (“edible”) preparations comprise an increasing segment of the cannabis market. To assess oral cannabis pharmacokinetics and pharmacodynamics, healthy adults (N =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9fd3f4eb5788b6750bacfd7c88da64
https://doi.org/10.1093/jat/bkx012

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Urinary Pharmacokinetic Profile of Cannabinoids Following Administration of Vaporized and Oral Cannabidiol and Vaporized CBD-Dominant Cannabis

Autor: George E. Bigelow, Ryan Vandrey, John M. Mitchell, Ronald Flegel, Edward J. Cone, David J. Kuntz, Tory R. Spindle

Publikováno v: J Anal Toxicol

Cannabis products in which cannabidiol (CBD) is the primary chemical constituent (CBD-dominant) are increasingly popular and widely available. The impact of CBD exposure on urine drug testing has not been well studied. This study characterized the ur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7228347b9d10ac9d78b04d82c30affee
https://pubmed.ncbi.nlm.nih.gov/31682266

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Urinary Excretion Profile of 11-Nor-9-Carboxy-Δ9-Tetrahydrocannabinol (THCCOOH) Following Smoked and Vaporized Cannabis Administration in Infrequent Cannabis Users

Autor: Edward J. Cone, Ryan Vandrey, John M. Mitchell, Nicolas J. Schlienz, Eugene D Hayes, George E. Bigelow, Tory R. Spindle, Ronald Flegel

Publikováno v: J Anal Toxicol

As cannabis has become more accessible, use of alternative methods for cannabis administration such as vaporizers has become more prevalent. Most prior controlled pharmacokinetic evaluations have examined smoked cannabis in frequent (often daily) can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4344976fa6f67a6e6b8202e2183136d3
https://pubmed.ncbi.nlm.nih.gov/31095692

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Acute Pharmacokinetic Profile of Smoked and Vaporized Cannabis in Human Blood and Oral Fluid

Autor: John M. Mitchell, Ronald Flegel, Nicolas J. Schlienz, Ryan Vandrey, Tory R. Spindle, Edward J. Cone, Eugene D Hayes, George E. Bigelow

Publikováno v: J Anal Toxicol

Currently, an unprecedented number of individuals can legally access cannabis. Vaporization is increasingly popular as a method to self-administer cannabis, partly due to perception of reduced harm compared with smoking. Few controlled laboratory stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba1141440fc78342f6ef7699e82de2f
https://europepmc.org/articles/PMC6676961/

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Prescription Opioids. V. Metabolism and Excretion of Oxymorphone in Urine Following Controlled Single Dose Administration

Autor: Anne Z, DePriest, Rebecca, Heltsley, David L, Black, John M, Mitchell, Charles, LoDico, Ronald, Flegel, Edward J, Cone

Publikováno v: Journal of Analytical Toxicology. 40:566-574

Oxymorphone (OM), a prescription opioid and metabolite of oxycodone, was included in the recently published proposed revisions to the Mandatory Guidelines for Federal Workplace Drug Testing Programs. To facilitate toxicological interpretation, this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c015ba97c36790347cf8ab25e1001dae
https://doi.org/10.1093/jat/bkw064

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