Zobrazeno 1 - 10
of 31
pro vyhledávání: '"John M. Matsoukas"'
Autor:
Harry Ridgway, Vasso Apostolopoulos, Graham J. Moore, Laura Kate Gadanec, Anthony Zulli, Jordan Swiderski, Sotirios Tsiodras, Konstantinos Kelaidonis, Christos T. Chasapis, John M. Matsoukas
Publikováno v:
Viruses, Vol 16, Iss 11, p 1776 (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza, and respiratory syncytial virus (RSV) are significant global health threats. The need for low-cost, easily synthesized oral drugs for rapid deployment during outbreaks is crucia
Externí odkaz:
https://doaj.org/article/effde1e4cc9546c1a3d7ad1ab0fc4087
Autor:
Harry Ridgway, John D. Orbell, Minos-Timotheos Matsoukas, Konstantinos Kelaidonis, Graham J. Moore, Sotiris Tsiodras, Vasilis G. Gorgoulis, Christos T. Chasapis, Vasso Apostolopoulos, John M. Matsoukas
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4589-4612 (2023)
Furins are serine endoproteases that process precursor proteins into their biologically active forms, and they play essential roles in normal metabolism and disease presentation, including promoting expression of bacterial virulence factors and viral
Externí odkaz:
https://doaj.org/article/c49dea784d9c4b30b61faf8fe083263b
Autor:
Harry Ridgway, Graham J. Moore, Thomas Mavromoustakos, Sotirios Tsiodras, Irene Ligielli, Konstantinos Kelaidonis, Christos T. Chasapis, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, Russell Petty, Ioannis Karakasiliotis, Vassilis G. Gorgoulis, John M. Matsoukas
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2091-2111 (2022)
The discovery and facile synthesis of a new class of sartan-like arterial antihypertensive drugs (angiotensin receptor blockers [ARBs]), subsequently referred to as “bisartans” is reported. In vivo results and complementary molecular modelling pr
Externí odkaz:
https://doaj.org/article/c273711c046740748e8c42638b922ec3
Autor:
Despoina P. Kiouri, Charalampos Ntallis, Konstantinos Kelaidonis, Massimiliano Peana, Sotirios Tsiodras, Thomas Mavromoustakos, Alessandro Giuliani, Harry Ridgway, Graham J. Moore, John M. Matsoukas, Christos T. Chasapis
Publikováno v:
Proteomes, Vol 11, Iss 2, p 21 (2023)
The potential of targeting the Renin-Angiotensin-Aldosterone System (RAAS) as a treatment for the coronavirus disease 2019 (COVID-19) is currently under investigation. One way to combat this disease involves the repurposing of angiotensin receptor bl
Externí odkaz:
https://doaj.org/article/b9dba9a5c93f4d56b563f3e09625703a
Autor:
Jordan Swiderski, Laura Kate Gadanec, Vasso Apostolopoulos, Graham J. Moore, Konstantinos Kelaidonis, John M. Matsoukas, Anthony Zulli
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 787 (2023)
Cardiovascular diseases (CVDs) are the main contributors to global morbidity and mortality. Major pathogenic phenotypes of CVDs include the development of endothelial dysfunction, oxidative stress, and hyper-inflammatory responses. These phenotypes h
Externí odkaz:
https://doaj.org/article/06b726c78186485ba573dccbd51f8787
Autor:
Harry Ridgway, Charalampos Ntallis, Christos T. Chasapis, Konstantinos Kelaidonis, Minos-Timotheos Matsoukas, Panagiotis Plotas, Vasso Apostolopoulos, Graham Moore, Sotirios Tsiodras, Dimitrios Paraskevis, Thomas Mavromoustakos, John M. Matsoukas
Publikováno v:
Viruses, Vol 15, Iss 2, p 309 (2023)
Background, Aims, Methods, Results, Conclusions: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global challenge due to its ability to mutate into variants that spread more rapidly than the wild-type virus. The molecular biology of
Externí odkaz:
https://doaj.org/article/bf4a94437923467e81a13e8f6ce5ed80
Autor:
John M. Matsoukas, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, Konstantinos Kelaidonis, Irene Ligielli, Kalliopi Moschovou, Nikitas Georgiou, Panagiotis Plotas, Christos T. Chasapis, Graham Moore, Harry Ridgway, Thomas Mavromoustakos
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1731 (2022)
Diminazene aceturate (DIZE) is a putative angiotensin-converting enzyme 2 (ACE2) activator and angiotensin type 1 receptor antagonist (AT1R). Its simple chemical structure possesses a negatively charged triazene segment that is homologous to the tetr
Externí odkaz:
https://doaj.org/article/7b5d7773b68e4ceaa0b69e34701d9cbb
Autor:
Graham J. Moore, Harry Ridgway, Konstantinos Kelaidonis, Christos T. Chasapis, Irene Ligielli, Thomas Mavromoustakos, Joanna Bojarska, John M. Matsoukas
Publikováno v:
Molecules, Vol 27, Iss 15, p 4854 (2022)
Angiotensin receptor blockers (ARBs) used in the treatment of hypertension and potentially in SARS-CoV-2 infection exhibit inverse agonist effects at angiotensin AR1 receptors, suggesting the receptor may have evolved to accommodate naturally occurri
Externí odkaz:
https://doaj.org/article/16c7f511d66a4c7f8ef39a135dff15e8
Autor:
Vasso Apostolopoulos, Joanna Bojarska, Tsun-Thai Chai, Jack Feehan, Krzysztof Kaczmarek, John M. Matsoukas, Octavio Paredes Lopez, Michele Saviano, Mariusz Skwarczynski, Jillian Smith-Carpenter, Mariano Venanzi, Wojciech M. Wolf, Piotr Zielenkiewicz, Zyta M. Ziora
Publikováno v:
Molecules, Vol 27, Iss 11, p 3635 (2022)
It is beyond doubt that short peptides hold significant promise in bio-medicine, as the most versatile molecules, both structurally and functionally [...]
Externí odkaz:
https://doaj.org/article/3c588846425b4f409504e03c45462da6
Autor:
Harry Ridgway, Christos T. Chasapis, Konstantinos Kelaidonis, Irene Ligielli, Graham J. Moore, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, Thomas Mavromoustakos, John M. Matsoukas
Publikováno v:
Viruses, Vol 14, Iss 5, p 1029 (2022)
SARS-CoV-2 is a global challenge due to its ability to mutate into variants that spread more rapidly than the wild-type virus. Because the molecular biology of this virus has been studied in such great detail, it represents an archetypal paradigm for
Externí odkaz:
https://doaj.org/article/693ec5b86d2b4c4ca9682b1260b5d669