Loss of immune tolerance to IL-2 in type 1 diabetes

Autor: Louis Pérol, John M. Lindner, Pamela Caudana, Nicolas Gonzalo Nunez, Audrey Baeyens, Andrea Valle, Christine Sedlik, Delphine Loirat, Olivier Boyer, Alain Créange, José Laurent Cohen, Ute Christine Rogner, Jun Yamanouchi, Martine Marchant, Xavier Charles Leber, Meike Scharenberg, Marie-Claude Gagnerault, Roberto Mallone, Manuela Battaglia, Pere Santamaria, Agnès Hartemann, Elisabetta Traggiai, Eliane Piaggio

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggest

Externí odkaz: https://doaj.org/article/db770a8739b84dbf870ffd96cace147e

T-FINDER: A highly sensitive, pan-HLA platform for functional T cell receptor and ligand discovery

Autor: Theresa Schmid, Miray Cetin, Veronica Pinamonti, Ana Mellado Fuentes, Kristina Kromer, Taga Lerner, Jing Zhang, Tamara Boschert, Yonatan Herzig, Christopher Ehlert, Laura Fisch, Valeriia Dragan, Arlette Kouwenhoven, Bertrand Van Schoubroeck, Hans Wils, Carl Van Hove, Michael Platten, Edward Green, Frederik Stevenaert, Nathan J. Felix, John M. Lindner

Effective, unbiased, high-throughput methods to functionally identify both class II and class I HLA-presented T cell epitopes and their cognate T cell receptors (TCRs) are essential for and prerequisite to diagnostic and therapeutic applications, yet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82919b45ad4a89bdeb0ca5cb007d52b9
https://doi.org/10.1101/2023.05.16.540992

Synthetic standards combined with error and bias correction improves the accuracy and quantitative resolution of antibody repertoire sequencing in human naïve and memory B cells

Autor: Vanessa Cornacchione, Simon Friedensohn, John M. Lindner, Sai T. Reddy, Simon M Meng, Mariavittoria Iazeolla, Andreas Zingg, Elisabetta Traggiai, Enkelejda Miho

Publikováno v: Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, 9
Frontiers in Immunology

High-throughput sequencing of immunoglobulin (Ig) repertoires (Ig-seq) is a powerful method for quantitatively interrogating B cell receptor sequence diversity. When applied to human repertoires, Ig-seq provides insight into fundamental immunological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c377f0dee547f78b9ff03779ca63ed9
https://doi.org/10.1101/284810

Loss of immune tolerance to IL-2 in type 1 diabetes

Autor: Roberto Mallone, Louis Pérol, Marie Claude Gagnerault, Alain Créange, Jun Yamanouchi, Meike Scharenberg, Pere Santamaria, Audrey Baeyens, Agnès Hartemann, José L. Cohen, Ute Christine Rogner, Olivier Boyer, Martine Marchant, Delphine Loirat, Elisabetta Traggiai, Christine Sedlik, Nicolás Gonzalo Núñez, Andrea Valle, Manuela Battaglia, Pamela Caudana, Eliane Piaggio, John M. Lindner, Xavier Charles Leber

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2016, 7 (1), ⟨10.1038/ncomms13027⟩
Nature Communications, 2016, 7 (1), ⟨10.1038/ncomms13027⟩
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

Type 1 diabetes (T1D) is characterized by a chronic, progressive autoimmune attack against pancreas-specific antigens, effecting the destruction of insulin-producing β-cells. Here we show interleukin-2 (IL-2) is a non-pancreatic autoimmune target in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1a6599e3f3adbacc9c30cefbeea295
https://doi.org/10.1038/ncomms13027