Zobrazeno 1 - 10
of 69
pro vyhledávání: '"John M. Lehman"'
Autor:
Lydia E. Hainley, Martina S. Hughson, Amithi Narendran, Ralph Smith, Justin Arthur, Alida Hayner-Buchan, David J. Conti, John M. Lehman, Thomas D. Friedrich
Publikováno v:
Viruses, Vol 13, Iss 7, p 1353 (2021)
The human BK polyomavirus (BKPyV) is latent in the kidneys of most adults, but can be reactivated in immunosuppressed states, such as following renal transplantation. If left unchecked, BK polyomavirus nephropathy (PyVAN) and possible graft loss may
Externí odkaz:
https://doaj.org/article/e1be5ee50af8442ea856442e9a43f861
Autor:
Thomas D. Friedrich, David J. Conti, Lydia E Hainley, Amithi Narendran, Justin Arthur, Alida Hayner-Buchan, John M. Lehman, Ralph L. Smith, Martina S Hughson
Publikováno v:
Viruses
Volume 13
Issue 7
Viruses, Vol 13, Iss 1353, p 1353 (2021)
Volume 13
Issue 7
Viruses, Vol 13, Iss 1353, p 1353 (2021)
The human BK polyomavirus (BKPyV) is latent in the kidneys of most adults, but can be reactivated in immunosuppressed states, such as following renal transplantation. If left unchecked, BK polyomavirus nephropathy (PyVAN) and possible graft loss may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9c6782141d0021318ea9682584a5c6
https://doi.org/10.3390/v13071353
https://doi.org/10.3390/v13071353
Autor:
Michael P. Trova, Keith D. Barnes, Curt Barford, Travis Benanti, Mark Bielaska, Lori Burry, John M. Lehman, Christine Murphy, Harold O’Grady, Denise Peace, Susan Salamone, Jennifer Smith, Patricia Snider, Joseph Toporowski, Steven Tregay, Alison Wilson, Michael Wyle, Xiaozhang Zheng, Thomas D. Friedrich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6608-6612
The introduction of an aryl ring onto the 4-position of the C-6 benzyl amino group of the Cdk inhibitor roscovitine (2), maintained the potent Cdk inhibition demonstrated by roscovitine (2) as well as greatly improving the antiproliferative activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b74222a35c5b64e239a7140455c1dba
https://doi.org/10.1016/j.bmcl.2009.10.025
https://doi.org/10.1016/j.bmcl.2009.10.025
Autor:
Susan Salamone, Steven Tregay, Brian I. Bliss, Michael P. Trova, Simon Haydar, Joseph Anthony Bilotta, Luis Alicea, Patricia Snider, Matthew P. Rainka, R. Jason Herr, Xiaozhang Zheng, Denise Peace, Thuy Nguyen Duong, Keith D. Barnes, Travis Benanti, Thomas D. Friedrich, Matthew R. Johnson, Mark Bielaska, Yu Hui, John M. Lehman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6613-6617
The introduction of an aryl ring onto the 4-position of the C-6 benzyl amino group of the Cdk inhibitor roscovitine (2), maintained the potent Cdk inhibition demonstrated by roscovitine (2) as well as greatly improving the antiproliferative activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc9ed62ae30c61b43e5febf5164cc35
https://doi.org/10.1016/j.bmcl.2009.10.011
https://doi.org/10.1016/j.bmcl.2009.10.011
Publikováno v:
Cytometry Part A. :10-18
Background Simian Virus 40 (SV40) infection of growth-arrested monkey kidney cells stimulates S phase entry and the continued synthesis of both viral and cellular DNA. Infected cells can attain total DNA contents as high as DNA Index, DI = 5.0–6.0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4291b38ef5e9d29700004779570f52
https://doi.org/10.1002/cyto.a.20185
https://doi.org/10.1002/cyto.a.20185
Implementation of virtual microscope slides in the annual pathobiology of cancer workshop laboratory
Publikováno v:
Human Pathology. 34:430-436
Virtual slides are digital facsimiles of glass microscope slides that, when viewed with a pan and zoom viewer, can emulate viewing a glass slide with a traditional microscope. Based on successful implementation of virtual slides in medical student hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::249568602112a53c0f0bf72c2c330db5
https://doi.org/10.1016/s0046-8177(03)00185-0
https://doi.org/10.1016/s0046-8177(03)00185-0
Publikováno v:
Cell Proliferation. 33:115-125
Cells transformed by the simian virus 40 (SV40) large T antigen (Tag) contain elevated levels of cellular p53 protein. To quantify this relationship, levels of p53 were measured in NIH 3T3 cells that expressed different concentrations of Tag. Using i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6f1fca91416be56ec326eb2162f37da
https://doi.org/10.1046/j.1365-2184.2000.00168.x
https://doi.org/10.1046/j.1365-2184.2000.00168.x
Publikováno v:
Experimental Cell Research. 251:121-127
The infection of monkey kidney (CV-1) cells with simian virus 40 (SV40) stimulates the cells into successive rounds of DNA synthesis without an intervening mitosis, leading to the acquisition of a >G2 DNA content. To elucidate the role of small t ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162fa2d07c26b06c4ce7ddff52734c9a
https://doi.org/10.1006/excr.1999.4572
https://doi.org/10.1006/excr.1999.4572
Publikováno v:
Cytometry. 31:260-264
Simian virus 40 (SV40) infection of quiescent monkey kidney cells stimulates two successive rounds of cellular DNA synthesis without an intervening mitosis. This uncoupling of S phase and mitosis indicates that SV40 modulates pathways regulating the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b38f3dd7051ad531b11fc58cc901f7bb
https://doi.org/10.1002/(sici)1097-0320(19980401)31:4<260::aid-cyto5>3.0.co
https://doi.org/10.1002/(sici)1097-0320(19980401)31:4<260::aid-cyto5>3.0.co
Autor:
Jac A. Nickoloff, John B. Little, John M. Lehman, Mary Jo Waltman, F. Andrew Ray, Paul M. Kraemer
Publikováno v:
Cytometry. 31:242-250
The SV40 T antigen causes numerical (aneuploidy) and structural (aberrations) chromosome damage when expressed in human diploid fibroblasts. This chromosome damage precedes the acquisition of neoplastic traits such as anchorage independence, colony f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba88fa9c7193d5f0a94c7e919dc1a30a
https://doi.org/10.1002/(sici)1097-0320(19980401)31:4<242::aid-cyto3>3.0.co
https://doi.org/10.1002/(sici)1097-0320(19980401)31:4<242::aid-cyto3>3.0.co