Zobrazeno 1 - 7
of 7
pro vyhledávání: '"John M. Hinckley"'
Autor:
James B. Reinecke, Amanda J. Saraf, John M. Hinckley, Amy C. Gross, Helene Le Pommellette, Sophia Vatelle, Matthew V. Cannon, Emily Franz, Maren Cam, Ryan D. Roberts
Publikováno v:
Cancer Research. 83:64-64
Metastasis remains the primary cause of morbidity in most solid tumors, yet the mechanisms by which tumors colonize distant tissues remain poorly understood. Osteosarcoma illustrates the need to address this knowledge gap—about 40% of patients diag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bc5e285bcedbde640bceb7ad065b75a
https://doi.org/10.1158/1538-7445.am2023-64
https://doi.org/10.1158/1538-7445.am2023-64
Publikováno v:
Cancer Research. 82:2511-2511
Four decades of intense effort have not improved outcomes for patients with osteosarcoma. Even though 35-40% of young people so treated still die from the disease, usually from complications related to lung metastasis, our standard of care remains un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac16d2637efbc22cc6b25e60ca80afd4
https://doi.org/10.1158/1538-7445.am2022-2511
https://doi.org/10.1158/1538-7445.am2022-2511
Autor:
Sanjana Rajan, James Brandon Reinecke, Amy C. Gross, Ryan D. Roberts, Maren Cam, John M. Hinckley
Publikováno v:
Cancer Research. 80:PO-123
Four decades of intense multinational efforts to improve outcomes for children and teenagers with osteosarcoma have failed. Today, we still treat patients with a regimen first developed in 1982. The same 35-40% of young people diagnosed with osteosar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f5424c8a44ac77f05851fff8ee2491b
https://doi.org/10.1158/1538-7445.tumhet2020-po-123
https://doi.org/10.1158/1538-7445.tumhet2020-po-123
Publikováno v:
Cancer Research. 80:PR10-PR10
Outcomes for patients diagnosed with osteosarcoma (OS) hinge primarily on whether or not they develop pulmonary metastasis. Looking to identify novel opportunities for therapeutic intervention, we have sought mechanisms that facilitate colonization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be1f5f5bf6d9cdf171675f65eb2b8301
https://doi.org/10.1158/1538-7445.pedca19-pr10
https://doi.org/10.1158/1538-7445.pedca19-pr10
Autor:
Sarah Winget, Doris A. Phelps, Amanda J. Saraf, Cheryl A. London, Hakan Cam, Xiaokui Mo, Michael Arnold, John M. Hinckley, Hemant K. Bid, Maren Cam, Ryan D. Roberts, Peter J. Houghton, Amy C. Gross, Laura Brandolini
Publikováno v:
JCI insight. 3(16)
Osteosarcoma (OS), a malignant tumor of bone, kills through aggressive metastatic spread almost exclusively to the lung. Mechanisms driving this tropism for lung tissue remain unknown, though likely invoke specific interactions between tumor cells an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd9cda2a2258dcb2408d95c9db15423
https://pubmed.ncbi.nlm.nih.gov/30135299
https://pubmed.ncbi.nlm.nih.gov/30135299
Publikováno v:
Cancer Research. 78:2134-2134
Osteosarcoma (OS) kills patients through aggressive metastatic spread, primarily to lung tissues. Our lab has sought to understand the tumor-host interactions that facilitate growth of OS cells specifically within the lung. We previously identified t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c33543135f864abbc416e4e2ba886da
https://doi.org/10.1158/1538-7445.am2018-2134
https://doi.org/10.1158/1538-7445.am2018-2134
Publikováno v:
Cancer Research. 78:4488-4488
The survival rate for patients diagnosed with osteosarcoma (OS) drops from 70% to an abysmal 20% when diagnosed with lung metastasis. We have shown that metastatic colonization of lungs by OS cells depends on the production of IL6 and CXCL8 by tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22a5e30d82e29aee79572309fbfabbdf
https://doi.org/10.1158/1538-7445.am2018-4488
https://doi.org/10.1158/1538-7445.am2018-4488