Zobrazeno 1 - 10
of 129
pro vyhledávání: '"John M. Higgins"'
Autor:
Daniel C. De Souza, Nicolas Hebert, Erica B. Esrick, M. Felicia Ciuculescu, Natasha M. Archer, Myriam Armant, Étienne Audureau, Christian Brendel, Giuseppe Di Caprio, Frédéric Galactéros, Donghui Liu, Amanda McCabe, Emily Morris, Ethan Schonbrun, Dillon Williams, David K. Wood, David A. Williams, Pablo Bartolucci, John M. Higgins
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract We previously reported initial clinical results of post-transcriptional gene silencing of BCL11A expression (NCT 03282656) reversing the fetal to adult hemoglobin switch. A goal of this approach is to increase fetal hemoglobin (HbF) expressi
Externí odkaz:
https://doaj.org/article/c27e3b0ea4ac4641bfd4b6b6b60347e0
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Inflammation is a protective response of the body. Here, authors show that healthy inflammation induces remarkably consistent changes in white cell and platelet populations, regardless of the underlying cause, including heart attack, infection and tr
Externí odkaz:
https://doaj.org/article/ad3c017b14d645ccb4d25d6cedfe0bd3
Autor:
Athena C. Geisness, Melissa Azul, Dillon Williams, Hannah Szafraniec, Daniel C. De Souza, John M. Higgins, David K. Wood
Publikováno v:
Haematologica, Vol 107, Iss 6 (2021)
Sickle cell disease (SCD) is characterized by sickle hemoglobin (HbS) which polymerizes under deoxygenated conditions to form a stiff, sickled erythrocyte. The dehydration of sickle erythrocytes increases intracellular HbS concentration and the prope
Externí odkaz:
https://doaj.org/article/2c9bacc87031420c84daa30f5d0874b2
Publikováno v:
APL Bioengineering, Vol 3, Iss 4, Pp 046102-046102-9 (2019)
The pathology of sickle cell disease begins with the polymerization of intracellular hemoglobin under low oxygen tension, which leads to increased blood effective viscosity and vaso-occlusion. However, it has remained unclear how single-cell changes
Externí odkaz:
https://doaj.org/article/18179ae6b464457cb523a7cd57bce7f5
Autor:
Francisco Feijó Delgado, Nathan Cermak, Vivian C. Hecht, Sungmin Son, Yingzhong Li, Scott M. Knudsen, Selim Olcum, John M. Higgins, Jianzhu Chen, William H. Grover, Scott R. Manalis
Publikováno v:
PLoS ONE, Vol 8, Iss 9 (2013)
Externí odkaz:
https://doaj.org/article/bc17dce362d2419eb81200befb05e3d9
Autor:
Peter G. Miller, Geoffrey G. Fell, Brody H. Foy, Allison K. Scherer, Christopher J. Gibson, Adam S. Sperling, Bala B. Burugula, Tetsushi Nakao, Md M. Uddin, Hailey Warren, Lynn Bry, Olga Pozdnyakova, Matthew J. Frigault, Alex G. Bick, Donna Neuberg, John M. Higgins, Michael K. Mansour, Pradeep Natarajan, Annette S. Kim, Jacob O. Kitzman, Benjamin L. Ebert
Publikováno v:
Blood. 140:1993-1997
Two Letters to Blood address the risks of COVID-19 in populations with precursors of hematological disease. In the first article, Miller and colleagues report on whether clonal hematopoiesis of intermediate potential (CHIP) is associated with adverse
Autor:
Brody Foy, Jonathan Stefely, Pavan K Bendapudi, Robert P. Hasserjian, Hanny Al-Samkari, Abner Louissaint, Megan Fitzpatrick, Bailey Hutchison, Christopher Mow, Julia Collins, Hasmukh Patel, Chhaya Patel, Nikita Patel, Samantha Ho, Richard M Kaufman, Walter 'Sunny' Dzik, John M Higgins, Robert S Makar
Publikováno v:
Blood Advances.
Examination of red blood cell (RBC) morphology in peripheral blood smears can help diagnose hematologic disease, even in resource-limited settings, but this analysis remains subjective and semi-quantitative with low throughput. Prior attempts to deve
Autor:
Yuhao Qiang, Abdoulaye Sissoko, Zixiang L. Liu, Ting Dong, Fuyin Zheng, Fang Kong, John M. Higgins, George E. Karniadakis, Pierre A. Buffet, Subra Suresh, Ming Dao
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The spleen clears altered red blood cells (RBCs) from circulation, contributing to the balance between RBC formation (erythropoiesis) and removal. The splenic RBC retention and elimination occur predominantly in open circulation where RBCs flow throu
Autor:
Maximilian J. Schloss, Maarten Hulsmans, David Rohde, I-Hsiu Lee, Nicolas Severe, Brody H. Foy, Fadi E. Pulous, Shuang Zhang, Konstantinos D. Kokkaliaris, Vanessa Frodermann, Gabriel Courties, Chongbo Yang, Yoshiko Iwamoto, Anders Steen Knudsen, Cameron S. McAlpine, Masahiro Yamazoe, Stephen P. Schmidt, Gregory R. Wojtkiewicz, Gustavo Santos Masson, Karin Gustafsson, Diane Capen, Dennis Brown, John M. Higgins, David T. Scadden, Peter Libby, Filip K. Swirski, Kamila Naxerova, Matthias Nahrendorf
Publikováno v:
Nature Immunology. 23:605-618
Autonomic nerves control organ function through the sympathetic and parasympathetic branches, which have opposite effects. In the bone marrow, sympathetic (adrenergic) nerves promote hematopoiesis; however, how parasympathetic (cholinergic) signals m
Autor:
Antonio Perazzo, Zhangli Peng, Y.-N. Young, Zhe Feng, David K. Wood, John M. Higgins, Howard A. Stone
Publikováno v:
Soft Matter
Sickle cell anemia (SCA) is a disease that affects red blood cells (RBCs). Healthy RBCs are highly deformable objects that under flow can penetrate blood capillaries smaller than their typical size. In SCA there is an impaired deformability of some c