Zobrazeno 1 - 10
of 284
pro vyhledávání: '"John M. Hickey"'
Autor:
Prashant Kumar, Michael Wang, Ozan S. Kumru, John M. Hickey, Julio Sanmiguel, Nerea Zabaleta, Luk H. Vandenberghe, Sangeeta B. Joshi, David B. Volkin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 103-121 (2023)
Recombinant adeno-associated viruses (rAAVs) are a preferred vector system in clinical gene transfer. A fundamental challenge to formulate and deliver rAAVs as stable and efficacious vaccines is to elucidate interrelationships between the vector’s
Externí odkaz:
https://doaj.org/article/c0cdad5aefc247faaa90ba08588e0e25
Autor:
Sungbong Jang, Roger Ros-Freixedes, John M. Hickey, Ching-Yi Chen, Justin Holl, William O. Herring, Ignacy Misztal, Daniela Lourenco
Publikováno v:
Genetics Selection Evolution, Vol 55, Iss 1, Pp 1-14 (2023)
Abstract Background Whole-genome sequence (WGS) data harbor causative variants that may not be present in standard single nucleotide polymorphism (SNP) chip data. The objective of this study was to investigate the impact of using preselected variants
Externí odkaz:
https://doaj.org/article/28cdcd2260864b89960a349718dc62ee
Autor:
Suzanne Desire, Martin Johnsson, Roger Ros-Freixedes, Ching-Yi Chen, Justin W. Holl, William O. Herring, Gregor Gorjanc, Richard J. Mellanby, John M. Hickey, Melissa K. Jungnickel
Publikováno v:
Genetics Selection Evolution, Vol 55, Iss 1, Pp 1-13 (2023)
Abstract Background Genome-wide association studies (GWAS) aim at identifying genomic regions involved in phenotype expression, but identifying causative variants is difficult. Pig Combined Annotation Dependent Depletion (pCADD) scores provide a meas
Externí odkaz:
https://doaj.org/article/6256dd90e214432991a89312e92ec1cc
Autor:
Ria T. Caringal, John M. Hickey, Nitya Sharma, Kaushal Jerajani, Oluwadara Bewaji, Sarah Brendle, Neil Christensen, Saurabh Batwal, Mustafa Mahedvi, Harish Rao, Vikas Dogar, Rahul Chandrasekharan, Umesh Shaligram, Sangeeta B. Joshi, David B. Volkin
Publikováno v:
Vaccines, Vol 12, Iss 6, p 580 (2024)
During the multi-dose formulation development of recombinant vaccine candidates, protein antigens can be destabilized by antimicrobial preservatives (APs). The degradation mechanisms are often poorly understood since available analytical tools are li
Externí odkaz:
https://doaj.org/article/bba59822ec044a848e29864c5e328c6a
Autor:
Ozan S. Kumru, Sakshi Bajoria, Kawaljit Kaur, John M. Hickey, Greta Van Slyke, Jennifer Doering, Katherine Berman, Charles Richardson, Hans Lien, Harry Kleanthous, Nicholas J. Mantis, Sangeeta B. Joshi, David B. Volkin
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 19, Iss 2 (2023)
ABSTRACTSecond-generation COVID-19 vaccines with improved immunogenicity (e.g., breadth, duration) and availability (e.g., lower costs, refrigerator stable) are needed to enhance global coverage. In this work, we formulated a clinical-stage SARS-CoV-
Externí odkaz:
https://doaj.org/article/158fc546f0eb4b9a9cde3509161cd3e9
Autor:
Roger Ros-Freixedes, Martin Johnsson, Andrew Whalen, Ching-Yi Chen, Bruno D. Valente, William O. Herring, Gregor Gorjanc, John M. Hickey
Publikováno v:
Genetics Selection Evolution, Vol 54, Iss 1, Pp 1-18 (2022)
Abstract Background Early simulations indicated that whole-genome sequence data (WGS) could improve the accuracy of genomic predictions within and across breeds. However, empirical results have been ambiguous so far. Large datasets that capture most
Externí odkaz:
https://doaj.org/article/8bad4d76ab95401eae3fa70898f1c7b0
Autor:
Roger Ros-Freixedes, Bruno D. Valente, Ching-Yi Chen, William O. Herring, Gregor Gorjanc, John M. Hickey, Martin Johnsson
Publikováno v:
Genetics Selection Evolution, Vol 54, Iss 1, Pp 1-16 (2022)
Abstract Background It is expected that functional, mainly missense and loss-of-function (LOF), and regulatory variants are responsible for most phenotypic differences between breeds and genetic lines of livestock species that have undergone diverse
Externí odkaz:
https://doaj.org/article/2a7e0249ae5c4d0a9f3144f43aca40a7
Autor:
Robert Jackson, Jaap B. Buntjer, Alison R. Bentley, Jacob Lage, Ed Byrne, Chris Burt, Peter Jack, Simon Berry, Edward Flatman, Bruno Poupard, Stephen Smith, Charlotte Hayes, Tobias Barber, Bethany Love, R. Chris Gaynor, Gregor Gorjanc, Phil Howell, Ian J. Mackay, John M. Hickey, Eric S. Ober
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Genomic selection has recently become an established part of breeding strategies in cereals. However, a limitation of linear genomic prediction models for complex traits such as yield is that these are unable to accommodate Genotype by Environment ef
Externí odkaz:
https://doaj.org/article/59d314d9f61c4d54a18320e861bd780b
Autor:
Sungbong Jang, Roger Ros-Freixedes, John M. Hickey, Ching-Yi Chen, William O. Herring, Justin Holl, Ignacy Misztal, Daniela Lourenco
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Genomic evaluations in pigs could benefit from using multi-line data along with whole-genome sequencing (WGS) if the data are large enough to represent the variability across populations. The objective of this study was to investigate strategies to c
Externí odkaz:
https://doaj.org/article/4e300998e1394d998658c19511691216
Publikováno v:
JDS Communications, Vol 2, Iss 6, Pp 366-370 (2021)
Breeding has increased genetic gain for dairy cattle in advanced economies but has had limited success in improving dairy cattle in low- to middle-income countries (LMIC). Genetic evaluations are a central component of delivering genetic gain, becaus
Externí odkaz:
https://doaj.org/article/f41db90dc2dd4c6a9ec07176dfd92843