Zobrazeno 1 - 10
of 30
pro vyhledávání: '"John M. Harrold"'
Autor:
Shu-Chen Lu, Michelle Chen, Larissa Atangan, Elizabeth A. Killion, Renee Komorowski, Yuan Cheng, Chawita Netirojjanakul, James R. Falsey, Marina Stolina, Denise Dwyer, Clarence Hale, Shanaka Stanislaus, Todd Hager, Veena A. Thomas, John M. Harrold, David J. Lloyd, Murielle M. Véniant
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100263- (2021)
Summary: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) regulate glucose and energy homeostasis. Targeting both pathways with GIP receptor (GIPR) antagonist antibody (GIPR-Ab) and GLP-1 receptor (GLP-1R) agonis
Externí odkaz:
https://doaj.org/article/6fa1243f07684a9b91237d0446fb0986
Autor:
Julie M. Bailis, Angela Coxon, Benno Rattel, Natalia Grinberg, Christian Brandl, John M. Harrold, Claudia Bluemel, Franziska Vogel, Christoph Dahlhoff, Petra Deegen, Natalie F. Mariano, Michael Lutteropp, Famke Aeffner, Matthias Friedrich, Elizabeth Pham
Includes supplemental methods, tables and figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08323e71546fa55ba8e62f0ad615d7c5
https://doi.org/10.1158/1535-7163.22521394.v1
https://doi.org/10.1158/1535-7163.22521394.v1
Autor:
Andrew T. Chow, John M. Harrold, Murad Melhem, Isabelle Delor, Juan Jose Perez-Ruixo, Philippe Jacqmin, Per Olsson Gisleskog
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 13, Iss 4, Pp 807-817 (2020)
Clinical and Translational Science, Vol 13, Iss 4, Pp 807-817 (2020)
Acute exposure to high doses of radiation leads to severe myelosuppression, but few treatments are currently available to treat hematopoietic syndrome of acute radiation syndrome. Granulocyte colony stimulating factors (e.g., filgrastim) stimulate pr
Autor:
Elizabeth T. Andrews, Stephanie C. Casey, Mohammad Farhad Amani, Grit Lorenczewski, Mozhgan Farshbaf, Lisa Winkel, Matthias Klinger, John M. Harrold, Famke Aeffner, Ana Goyos, Matthias Friedrich, Tara Arvedson, Matthew G. Chun
Publikováno v:
Cancer Research. 82:6251-6251
Multiple myeloma (MM) is a cancer of the antibody-producing plasma cells (PC). MM is invariably fatal due to frequent disease relapse and/or treatment refractoriness, and therapies that provide deeper and more durable responses are needed. BiTE® (Bi
Autor:
Natalia Grinberg, Benno Rattel, Natalie F. Mariano, Christoph Dahlhoff, Franziska Vogel, Claudia Bluemel, Famke Aeffner, Petra Deegen, Matthias Friedrich, Michael Lutteropp, Julie M. Bailis, Angela Coxon, Elizabeth Pham, Christian Brandl, John M. Harrold
Publikováno v:
Molecular cancer therapeutics. 20(10)
MUC12 is a transmembrane mucin that is highly expressed in >50% of primary and metastatic colorectal tumors. MUC12 is also expressed by normal epithelial cells of the colon and small intestine. Although MUC12 localization in normal epithelial cells i
Autor:
Raushan Kurmasheva, Olivier Nolan-Stevaux, John R. Desjarlais, Matthew J. Bernett, Peter J. Houghton, Rodolfo Yabut, Cong Li, Tao Osgood, Anna Rogojina, Umesh Muchhal, Madeline M. Fort, Jude Canon, Gregory T. Moore, John M. Harrold, Sarav Kaliyaperumal, Lingming Liang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Metastatic castration-resistant prostate cancer (mCRPC) and Ewing sarcoma (EWS) are diseases for which immune therapies could potentially provide benefit. STEAP1 (Six Transmembrane Epithelial Antigen of the Prostate 1) is a cell surface pr
Autor:
Juan Jose Perez-Ruixo, Isabelle Delor, Sameer Doshi, Andrew T. Chow, Murad Melhem, Per Olsson Gisleskog, Philippe Jacqmin, Bing-Bing Yang, John M. Harrold, Adimoolam Narayanan
Publikováno v:
Pharmaceutical Research
Purpose To model absolute neutrophil count (ANC) suppression in response to acute radiation (AR) exposure and evaluate ANC time course as a predictor of overall survival (OS) in response to AR exposure with or without treatment with granulocyte colon
Autor:
Elizabeth A. Killion, Yuan Cheng, John M. Harrold, Veena A. Thomas, Shu-Chen Lu, James R. Falsey, Chawita Netirojjanakul, David Lloyd, Clarence Hale, Todd Hager, Shanaka Stanislaus, Marina Stolina, Renee Komorowski, Larissa Atangan, Murielle M. Véniant, Denise Dwyer, Michelle Chen
Publikováno v:
Cell Reports Medicine
Cell Reports Medicine, Vol 2, Iss 5, Pp 100263-(2021)
Cell Reports Medicine, Vol 2, Iss 5, Pp 100263-(2021)
Summary Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) regulate glucose and energy homeostasis. Targeting both pathways with GIP receptor (GIPR) antagonist antibody (GIPR-Ab) and GLP-1 receptor (GLP-1R) agonist
Autor:
Andrew T. Chow, Liviawati Wu, Philippe Jacqmin, Juan Jose Perez-Ruixo, Isabelle Delor, Murad Melhem, John M. Harrold
Publikováno v:
British Journal of Clinical Pharmacology. 84:911-925
Aim The objective of the present study was to use pharmacokinetic-pharmacodynamic modelling to characterize the effects of chemotherapy on the granulopoietic system and to predict the absolute neutrophil counts (ANCs) for patients with chemotherapy-i