Výsledky vyhledávání - "John M. Gruber"

A green-by-design biocatalytic process for atorvastatin intermediate

Autor: John H. Grate, Gray David R, Christopher S Davis, Roger A. Sheldon, John M. Gruber, Alica Wang, Steven K. Ma, Gjalt W. Huisman, Lisa M. Newman

Publikováno v: Green Chem.. 12:81-86

The development of a green-by-design, two-step, three-enzyme process for the synthesis of a key intermediate in the manufacture of atorvastatin, the active ingredient of the cholesterol lowering drug Lipitor®, is described. The first step involves t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d75a7be10925b2914481e0917afc17e
https://doi.org/10.1039/b919115c

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Improving catalytic function by ProSAR-driven enzyme evolution

Autor: Roger A. Sheldon, Lisa M. Newman, Emily Mundorff, Richard J. Fox, John C Whitman, Gjalt W. Huisman, Loleta M Chung, Steven K. Ma, S. Christopher Davis, Charlene Ching, John M. Gruber, Vesna Gavrilovic, John H. Grate, Sheela Muley, Sarena Tam

Publikováno v: Nature Biotechnology. 25:338-344

We describe a directed evolution approach that should find broad application in generating enzymes that meet predefined process-design criteria. It augments recombination-based directed evolution by incorporating a strategy for statistical analysis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4402e955f779b04c3061c8cc90a7d03
https://doi.org/10.1038/nbt1286

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α-Hydroxy Ketones from the Oxidation of Enol Silyl Ethers withm-Chloroperbenzoic Acid: 6-Hydroxy- 3,5,5-Trimethyl-2-Cyclohexen-1-one

Autor: Dan A. Charleson, George M. Rubottom, Henrik D. Juve, John M. Gruber

Publikováno v: Organic Syntheses

α-Hydroxy ketones from the oxidation of enol silyl ethers with m-chloroperbenzoic acid: 6-hydroxy- 3,5,5-trimethyl-2-cyclohexen-1-one solvent: 11.25 mL (80.4 mmol) of freshly distilled diisopropylamine reactant: 10.0 g (72.4 mmol) of freshly distill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e799698fb013b6f26ac5005cd7c7101
https://doi.org/10.1002/0471264180.os064.19

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Alkylation-Reduction of Carbonyl Systems. V. The Selective Synthesis ofo-Tolylphenylmethanol ando-Tolylphenylmethane by Phenylation-Reduction of Benzocyclobutenone

Autor: Frank J. McEnroe, Richard J. Spangler, John M. Gruber, Stan S. Hall

Publikováno v: Synthetic Communications. 5:441-444

For some time this laboratory has been developing the concept of tandem alkylation-reduction as a convenient method of preparing aromatic hydrocarbons by the lithium-ammonia reduction of benzyl alkoxides generated in situ by alkylation.1 In these as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbad735847bcbfd357b07fa46c1dc0a7
https://doi.org/10.1080/00397917508065578

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Total syntheses of (±)-cycloseychellene and (±)-seychellene

Autor: Steven C. Welch, P. A. Morrison, John M. Gruber

Publikováno v: Tetrahedron Letters. 25:5497-5500

Total syntheses of (±)-cycloseychellene (1) and (±)-seychellene (2) from 2,5-dimethylcyclohexanone (3) are described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7682948cc4fac8abb6742df371139a40
https://doi.org/10.1016/s0040-4039(01)81609-9

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Total syntheses of (.+-.)-seychellene, (.+-.)-isocycloseychellene, and (.+-.)-isoseychellene

Autor: John M. Gruber, Chihyueh Chou, Steven C. Welch, Jean Marie Assercq

Publikováno v: The Journal of Organic Chemistry. 50:2668-2676

Synthese a partir de la dimethyl-2,5 cyclohexanone. Reisolation et determination de la structure du cycloseychellene naturel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78e8619c6779dcf9e0acf230401ca783
https://doi.org/10.1021/jo00215a015

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Epoxidation of retinol and the structure of 'chromogen 574'

Autor: A. S. C. Prakasa Rao, Steven C. Welch, John M. Gruber

Publikováno v: Tetrahedron. 36:1179-1182

Epoxidation of retinol (vitamin A alcohol, 1) with freshly prepared and standardized mono-perphthalic acid in ether affords a product which Karrer named “chromogen 574” in 1945. Repetition of this peracid oxidation of retinol (1) with several per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22d717d394678f81512fd1514401513b
https://doi.org/10.1016/0040-4020(80)87015-3

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