Multiple Sclerosis: Are Protective Immune Mechanisms Compromised by a Complex Infectious Background?

Autor: Bernd Krone, John M. Grange

Publikováno v: Autoimmune Diseases, Vol 2011 (2011)

The immunological background of multiple sclerosis (MS) manifests as an altered reactivity against a diverse range of infections, particularly with the Epstein-Barr virus. Although this could be only an epiphenomenon of a more generalised dysfunction

Externí odkaz: https://doaj.org/article/b91804cbd9dc4f0092911dc27be000ae

Viewpoint: Scientific dogmas, paradoxes and mysteries of latent Mycobacterium tuberculosis infection

Autor: Michael Hoelscher, Zhenkun Ma, John M. Grange, Markus Maeurer, Alimuddin Zumla, Rifat Atun, Matthew Bates, Keertan Dheda, Peter Mwaba, Justin O'Grady

Publikováno v: Tropical Medicine & International Health. 16:79-83

Worldwide, there are nearly 10 million new cases of active TB and 1.8 million associated deaths every year. WHO estimates that one-third of the world's population is infected with Mycobacterium tuberculosis (Mtb), forming a huge latent Mtb global res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae766fa35d9dbf511cf9f79615e245c7
https://doi.org/10.1111/j.1365-3156.2010.02665.x

Chronic inflammation as a manifestation of defects in immunoregulatory networks: implications for novel therapies based on microbial products

Autor: John L. Stanford, Guillermo Horacio Docena, Oscar Bottasso, John M. Grange

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

Based on a unifying theory presented here, it is predicted that the immune defects resulting in chronic inflammation rather than effective immune responses could be rectified by the therapeutic use of agents prepared from micro-organisms. With approp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1558bb6aba5bc2a5096b1996b437c391
https://doi.org/10.1007/s10787-009-0008-x

The use of mycobacterial adjuvant-based agents for immunotherapy of cancer

Autor: Oscar Bottasso, C.A. Stanford, John M. Grange, John L. Stanford

Publikováno v: Vaccine. 26:4984-4990

A heat-killed preparation of Mycobacterium vaccae (SRL172) has been shown, in recent studies, to be effective in the treatment of adenocarcinoma of the lung and renal cell cancer. It is postulated that the mechanisms of this form of immunotherapy is,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c48f44a687af41239ccbf0f2f3d7c07
https://doi.org/10.1016/j.vaccine.2008.06.092

Common infectious agents in multiple sclerosis: a case—control study in children

Autor: John M. Grange, Bernd Krone, Frank Oeffner, Folkner Hanefeld, Kevin Rostasy, Jutta Gärtner, Daniela Pohl, Edgar Brunner, Elke Kahler

Publikováno v: Multiple Sclerosis Journal. 14:136-139

Environmental factors, in particular infections, have been linked with the risk of developing multiple sclerosis (MS). The association of Epstein—Barr virus infection with childhood onset of MS has been recently recognized. As other infections char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59d65d4e4b342fe1cff0ba147136f5d
https://doi.org/10.1177/1352458507082069