Zobrazeno 1 - 10
of 193
pro vyhledávání: '"John M. Essigmann"'
Autor:
Bogdan I. Fedeles, Supawadee Chawanthayatham, Robert G. Croy, Gerald N. Wogan, John M. Essigmann
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 4 (2017)
Using duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B1 in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnos
Externí odkaz:
https://doaj.org/article/05309f2c5a934343a7416f7218e559cf
Autor:
Deyu Li, James C. Delaney, Charlotte M. Page, Alvin S. Chen, Cintyu Wong, Catherine L. Drennan, John M. Essigmann
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
DNA alkylation can cause mutations, epigenetic changes, and even cell death. All living organisms have evolved enzymatic and non-enzymatic strategies for repairing such alkylation damage. AlkB, one of the Escherichia coli adaptive response proteins,
Externí odkaz:
https://doaj.org/article/72c0ce95c6494c019c622d58039844e0
Publikováno v:
Dalton Transactions. 52:3219-3233
Binuclear Cu(i) complexes bearing N-heterocycles-containing phosphines function as luminescent sensors for N-nitrosamines.
Autor:
Ashis K. Basu, John M. Essigmann
Publikováno v:
Chem Res Toxicol
DNA damage by chemicals, radiation, or oxidative stress leads to a mutational spectrum, which is complex because it is determined in part by lesion structure, the DNA sequence context of the lesion, lesion repair kinetics, and the type of cells in wh
Autor:
Amanda L Armijo, Pennapa Thongararm, Bogdan I Fedeles, Judy Yau, Jennifer E Kay, Joshua J Corrigan, Marisa Chancharoen, Supawadee Chawanthayatham, Leona D Samson, Sebastian E Carrasco, Bevin P Engelward, James G Fox, Robert G Croy, John M Essigmann
Publikováno v:
NAR Cancer. 5
DNA-methylating environmental carcinogens such as N-nitrosodimethylamine (NDMA) and certain alkylators used in chemotherapy form O6-methylguanine (m6G) as a functionally critical intermediate. NDMA is a multi-organ carcinogen found in contaminated wa
Publikováno v:
J Am Chem Soc
N-Nitrosamines are found in food, drugs, air, water, and soil. They pose a significant risk to human health because of their carcinogenicity; consequently, materials that can be used to selectively and sensitively detect nitrosamines are needed. In t
Autor:
Andrey V Aralov, Nina Gubina, Cristina Cabrero, Vladimir B Tsvetkov, Anton V Turaev, Bogdan I Fedeles, Robert G Croy, Ekaterina A Isaakova, Denis Melnik, Svetlana Dukova, Dmitriy Y Ryazantsev, Alexei A Khrulev, Anna M Varizhuk, Carlos González, Timofei S Zatsepin, John M Essigmann
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
14 pags., 9 figs.
This work investigated the structural and biological properties of DNA containing 7,8-dihydro-8-oxo-1,N6-ethenoadenine (oxo-ϵA), a non-natural synthetic base that combines structural features of two naturally occurring DNA les
This work investigated the structural and biological properties of DNA containing 7,8-dihydro-8-oxo-1,N6-ethenoadenine (oxo-ϵA), a non-natural synthetic base that combines structural features of two naturally occurring DNA les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9a0e96021c16b9d7b61161c12d1e47
http://hdl.handle.net/10261/268285
http://hdl.handle.net/10261/268285
Autor:
Jutamaad Satayavivad, Bogdan I. Fedeles, John M. Essigmann, Nuchanart Rangkadilok, Preechaya Tajai, Tawit Suriyo
Publikováno v:
Asian Pacific Journal of Cancer Prevention. 22:3-8
Paraquat (1,1'-dimethyl, 4,4'-bipyridinium dichloride; PQ), a commonly used herbicide worldwide, is both toxic and mutagenic. The mutagenic effect of PQ stems from its ability to redox-cycle, generating oxidative stress and subsequently oxidative DNA
Autor:
Lina Kim, Jeerawan Promvijit, Apinya Thiantanawat, Amanda L. Armijo, Panida Navasumrit, Robert G. Croy, Pennapa Thongararm, Sakunchai Khumsubdee, Bogdan I. Fedeles, John M. Essigmann, Mathuros Ruchirawat
Publikováno v:
Chemical Research in Toxicology. 33:625-633
DNA methylating agents are abundant in the environment and are sometimes used in cancer chemotherapy. They react with DNA to form methyl-DNA adducts and byproduct lesions that can be both toxic and...
Publikováno v:
ACS Sensors. 4:2819-2824
N-Nitrosamines are environmental genotoxicants that are widely encountered in air, water, and food. Contamination of indoor and outdoor air with N-nitrosamines has been reported on many occasions. Conventional detection of airborne N-nitrosamines req