Zobrazeno 1 - 10
of 21
pro vyhledávání: '"John M. Essery"'
Publikováno v:
Expert Opinion on Investigational Drugs. 3:133-144
One of the most commercially successful classes of human antibacterials is the cephalosporins, intially introduced in the 1960s, commanding a major market share worldwide. The cephalosporins have evolved slowly, keeping intact the 7R-amino-cephalospo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b5f0d7d610bb3a6c88a38af3a03f309
https://doi.org/10.1517/13543784.3.2.133
https://doi.org/10.1517/13543784.3.2.133
Publikováno v:
Journal of Medicinal Chemistry. 22:263-269
The synthesis of some 1,6-dihydro-6-oxo-2-phenylpyrimidine-5-carboxylic acids and esters with potent oral and intravenous antiallergic activity against passive cutaneous anaphylaxis in the rat is described. Requirements for high activity include a fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7dbc9a649511156974f8c3a1f58ec1
https://doi.org/10.1021/jm00189a009
https://doi.org/10.1021/jm00189a009
Publikováno v:
Journal of Medicinal Chemistry. 22:1425-1428
The synthesis of analogues of carminomycin in which the daunosamine group has been replaced by (cis- and trans-3-aminocyclohexane)thio moieties is described. The new compounds were found to exhibit none of the antitumor or antibiotic activity associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064088b10eaa143c0dd91f2cb4d82cf6
https://doi.org/10.1021/jm00197a029
https://doi.org/10.1021/jm00197a029
Autor:
J. Huftalen, S. Nachfolger, H. G. Howell, John M. Essery, William C. Rose, E. Cundliffe, H. Schmitz, Richard A. Partyka, Terrence W. Doyle, O'Herron Fa, T. Kaneko, J. Davies, W. T. Bradner
Publikováno v:
Journal of Medicinal Chemistry. 25:579-589
Approximately 60 derivatives of anguidin were prepared for evaluation of antitumor activities. Positions 3, 4, 8-10, and 15 were modified, and the resultant derivatives were screened against P-388 leukemia. It was found that introduction of the C3-ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbb7478ca9b95057b1128b31e128f88
https://doi.org/10.1021/jm00347a018
https://doi.org/10.1021/jm00347a018
Publikováno v:
Journal of Medicinal Chemistry. 25:1145-1150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9186cd867c4fe32dfa23c8182b91c5a7
https://doi.org/10.1021/jm00352a009
https://doi.org/10.1021/jm00352a009
Autor:
John M. Essery, Terrence W. Doyle
Publikováno v:
Canadian Journal of Chemistry. 58:1869-1874
The epimerisation at C10 of ε-rhodomycinone by aqueous alkali treatment of its 6,7-acetonide is described. Daunosaminyl ε-rhodomycinone and daunosaminyl 10-epi-ε-rhodomycinone were prepared and compared with regard to their antibacterial propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313705347fb2342e2e7125954baf1f17
https://doi.org/10.1139/v80-295
https://doi.org/10.1139/v80-295
Autor:
David Willner, Crast Leonard B, John M. Essery, Peter F. Misco, Mcgregor Donald N, Ute Corbin, Robert G. Graham, Lee C Cheney, Vilmars Sprancmanis
Publikováno v:
The Journal of Antibiotics. 27:573-578
A series of new derivatives of 7-aminocephalosporanic acid in which the acetoxymethylfunction at C3 has been replaced with a heteroaromatic carbonylthiomethylmoiety and the 7-amino group has been acylated with D-phenylglycine has beenprepared. Many o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977d5dd7eb21107ca5076d26c89883f6
https://doi.org/10.7164/antibiotics.27.573
https://doi.org/10.7164/antibiotics.27.573
Autor:
Lee C Cheney, J. C. Godfrey, M E Neubert, C A Panetta, R R Fraser, Charles Truman Holdrege, William J. Gottstein, Crast Leonard B, R B Babel, W. F. Minor, John M. Essery
Publikováno v:
Journal of Medicinal Chemistry. 8:794-797
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d91983ada1501719f92d5552c4505249
https://doi.org/10.1021/jm00330a014
https://doi.org/10.1021/jm00330a014
Autor:
John M. Essery, Terrence W. Doyle
Publikováno v:
The Journal of Antibiotics. 32:247-249
The conversion of epsilon-rhodomycinone to its 11-methyl ether via selective hydrolysis of the 4,6,7,11-tetraacetate is described. This series of reactions was used as a model for the conversion of carminomycin to its 11-methyl ether. The anti-tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72514359ed95b32f98bd69270e29b77
https://doi.org/10.7164/antibiotics.32.247
https://doi.org/10.7164/antibiotics.32.247
Autor:
John M. Essery, William J. Gottstein, G. E. Bocian, Crast Leonard B, J. C. Godfrey, Lee C Cheney, Kathleen Dadabo
Publikováno v:
The Journal of Organic Chemistry. 31:1922-1924
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43ac71cfd50d20d9102445f3b0dc6008
https://doi.org/10.1021/jo01344a058
https://doi.org/10.1021/jo01344a058