Zobrazeno 1 - 8
of 8
pro vyhledávání: '"John M. Edgar"'
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract The generation of T-cells from stem cells in vitro could provide an alternative source of cells for immunotherapies. T-cell development from hematopoietic stem and progenitor cells (HSPCs) is tightly regulated through Notch pathway activatio
Externí odkaz:
https://doaj.org/article/71cda5e4d6d64e01a7fc4d2753c6d8d5
Autor:
Laura N Stankiewicz, Kevin Salim, Emily A Flaschner, Yu Xin Wang, John M Edgar, Bruce ZB Lin, Grace C Bingham, Matthew C Major, Ross D Jones, Helen M Blau, Elizabeth J Rideout, Megan K Levings, Peter W Zandstra, Fabio MV Rossi
Publikováno v:
bioRxiv
SummaryWithin the thymus, regulation of the cellular cross-talk directing T cell development is dependent on spatial interactions within specialized niches. To create a holistic, spatially defined map of tissue niches guiding postnatal T cell develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7bca0c46114847f2a5ad4602946ecd
https://doi.org/10.1101/2023.04.13.536804
https://doi.org/10.1101/2023.04.13.536804
Autor:
Yale S. Michaels, John M. Edgar, Matthew C. Major, Elizabeth L. Castle, Carla Zimmerman, Ting Yin, Andrew Hagner, Charles Lau, Han Hsuan Hsu, M. Iliana Ibañez-Rios, Lauren J. Durland, David J. H. F. Knapp, Peter W. Zandstra
Publikováno v:
Science Advances. 8
T cells show tremendous efficacy as cellular therapeutics. However, obtaining primary T cells from human donors is expensive and variable. Pluripotent stem cells (PSCs) have the potential to provide a renewable source of T cells, but differentiating
Autor:
John M. Edgar, Peter W. Zandstra
T-cell development from hematopoietic stem and progenitor cells (HSPCs) is tightly regulated through Notch pathway activation by the Notch ligands Delta-like (DL) 1 and 4 and Jagged-2. Other molecules, such as stem cell factor (SCF), FMS-like tyrosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cd4ccec3b195291da853bae742b6bf3
https://doi.org/10.1101/2021.01.18.427186
https://doi.org/10.1101/2021.01.18.427186
Autor:
Emma Bibault, Stephanie M. Willerth, Jose Carlos Gomez, Amy Montgomery, Nima Khadem Mohtaram, Andrew Agbay, John M. Edgar
Publikováno v:
Cellular and Molecular Bioengineering. 8:307-319
Pluripotent stem cells (PSCs) can form any specialized cell type found in the body making them an excellent tool for regenerative medicine applications. Directed differentiation of PSCs into specific phenotypes can be accomplished by introducing spec
Publikováno v:
Acta biomaterialia. 51
We hypothesized that generating spinal motor neurons (sMNs) from human induced pluripotent stem cell (hiPSC)-derived neural aggregates (NAs) using a chemically-defined differentiation protocol would be more effective inside of 3D fibrin hydrogels com
Autor:
John M. Edgar, Jastaranpreet Singh, Mahmood Mohtashami, Shreya Shukla, Juan Carlos Zúñiga-Pflücker, Peter W. Zandstra, Matthew A Langley
Publikováno v:
Nature methods. 14(5)
The molecular and cellular signals that guide T-cell development from hematopoietic stem and progenitor cells (HSPCs) remain poorly understood. The thymic microenvironment integrates multiple niche molecules to potentiate T-cell development in vivo.
Autor:
Andrew Agbay, Julian Schroll, Stephanie M. Willerth, Meghan Robinson, Tara Styan, Martin B.G. Jun, Nima Khadem Mohtaram, Junghyuk Ko, John M. Edgar, Krista Wilson
Publikováno v:
Cells, tissues, organs. 202(1-2)
Ongoing clinical trials are evaluating the use of stem cells as a way to treat traumatic spinal cord injury (SCI). However, the inhibitory environment present in the injured spinal cord makes it challenging to achieve the survival of these cells alon