Výsledky vyhledávání - "John M. Curto"

Palladium-Catalyzed Chemoselective Activation of sp3 vs sp2 C–H Bonds: Oxidative Coupling To Form Quaternary Centers

Autor: Peter Amadeo, Kelsey F. VanGelder, Arjun Vijeta, Uday Kumar Neelam, Marisa C. Kozlowski, Gang Hong, Pradip D Nahide, Charles E Hendrick, John M. Curto

Publikováno v: ACS Catalysis. 9:3716-3724

The oxidative activation of alkyl C-H bonds vs arene C-H bonds with Pd(OAc)2 has been found to be generalizable to a number of nucleophilic substrates allowing the formation of a range of hindered quaternary centers. The substrates share a common mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acdf19a8d939fb112de826c9e2ec7737
https://doi.org/10.1021/acscatal.9b00091

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Lewis Acid-Promoted Enantioselective Dearomative Spirocyclizations of Allenes

Autor: Sergei Tcyrulnikov, Philip H. Gilmartin, John M. Curto, Marisa C. Kozlowski

Publikováno v: The Journal of Organic Chemistry. 83:12207-12212

A chiral oxazaborolidine combined with SnCl4 has been found to promote the dearomative spirocyclization of electron-rich benzyl allenyl ketones. The reaction outcome is sensitive to the nature of activating acid, which was rationalized using hard–s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9f3006e40903b6fd174ae7ec798968
https://doi.org/10.1021/acs.joc.8b01565

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α-Allyl-α-aryl α-Amino Esters in the Asymmetric Synthesis of Acyclic and Cyclic Amino Acid Derivatives by Alkene Metathesis

Autor: Marisa C. Kozlowski, John M. Curto

Publikováno v: The Journal of Organic Chemistry

Allylating agents were explored for the asymmetric synthesis of α-allyl-α-aryl α-amino acids by tandem N-alkylation/π-allylation. Cross-metathesis of the tandem product was developed to provide allylic diversity not afforded in the parent reactio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4045a6326489c07b11672fc4c78f3642
https://doi.org/10.1021/jo500707t

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Asymmetric Synthesis of α-Allyl-α-Aryl α-Amino Acids by Tandem Alkylation/π-Allylation of α-Iminoesters

Autor: Marisa C. Kozlowski, Joshua S. Dickstein, Simon Berritt, John M. Curto

Publikováno v: Organic Letters

The first asymmetric synthesis of α-allyl-α-aryl α-amino acids by means of a three-component coupling of α-iminoesters, Grignard reagents, and cinnamyl acetate is reported. Notably, the enolate from the tandem process provides a much higher level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3883086fcce060c11631a21e3317d6
https://doi.org/10.1021/ol500506t

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