Zobrazeno 1 - 10
of 40
pro vyhledávání: '"John M. Candy"'
Autor:
William D. Ehmann, John M. Candy, Paul G. Ince, Lav Tandon, David Mantle, William R. Markesbery, Pamela J. Shaw
Publikováno v:
Neuroscience Letters. 182:87-90
Oxygen free radical damage is strongly implicated in the pathogenesis of familial motor neuron disease (MND) associated with mutation of the Cu/Zn superoxide dismutase gene, and may be relevant in sporadic MND. Selenium (Se) and iron (Fe) have import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090c63d76d4e5efef7ddf7df5d993d94
https://doi.org/10.1016/0304-3940(94)90213-5
https://doi.org/10.1016/0304-3940(94)90213-5
Autor:
Claude Michel Wischik, J.A Edwardson, John M. Candy, F.K. McArthur, Charles R. Harrington, G.A. Taylor
Publikováno v:
The Lancet. 343:993-997
Tau protein is a major structural protein of the paired helical filaments (PHFs) found in both neuritic senile plaques and neurofibrillary tangles in Alzheimer's disease (AD). Senile plaques also contain amyloid beta protein (A beta). We did an immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc85269b0a03dfb538fcfc5fa973a02e
https://doi.org/10.1016/s0140-6736(94)90124-4
https://doi.org/10.1016/s0140-6736(94)90124-4
Autor:
John M. Candy, Simon A. Mountfort, Christopher Morris, James A. Edwardson, Geoffrey A. Taylor, Hugh E. Bishop, Arthur E. Oakley
Publikováno v:
Biology of the Cell. 74:109-118
Dynamic secondary ion mass spectrometry (SIMS) has been utilised to study the post-mortem distribution of aluminium in air-dried frozen sections from unfixed, unstained human brain in order to minimise contamination of the tissue and avoid redistribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3102b266a2a092c7d31fb3844777c9
https://doi.org/10.1016/0248-4900(92)90016-t
https://doi.org/10.1016/0248-4900(92)90016-t
Publikováno v:
Brain Research. 565:42-47
Specific [3H]nitrendipine binding which was shown to be calcium- and calmodulin-dependent was found to be significantly reduced in the temporal cortex in Alzheimer's disease compared to age-matched controls. Scatchard analysis revealed that this redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abdb6576db3af69cb41a844fffc9021
https://doi.org/10.1016/0006-8993(91)91734-i
https://doi.org/10.1016/0006-8993(91)91734-i
Autor:
Lav Tandon, John M. Candy, Paul G. Ince, William D. Ehmann, William R. Markesbery, Pamela J. Shaw, Michael A. Deibel
Publikováno v:
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. 4(4)
Levels of 10 trace elements were analysed in autopsied lumbar spinal cords of 38 motor neuron disease patients and 22 control subjects using instrumental neutron activation analysis. Statistically significant elevations of iron, selenium and zinc, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f1b1e0702a0baf5fc6306ee83842ac
https://pubmed.ncbi.nlm.nih.gov/8846231
https://pubmed.ncbi.nlm.nih.gov/8846231
Autor:
Paul G. Ince, James A. Edwardson, Fiona K. McArthur, Ansgar Torvik, John M. Candy, Espen Bjertness
Publikováno v:
Dementia (Basel, Switzerland). 6(3)
Neuropathological changes in elderly residents of Oslo, Norway, were characterised with respect to the cerebral substrates of dementia. Ninety-two brains were examined, representing 41% of all deaths occurring in 10 nursing homes during a 9-month per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc2aaa7f0c9ce63859b3002bb650801
https://pubmed.ncbi.nlm.nih.gov/7620529
https://pubmed.ncbi.nlm.nih.gov/7620529
Publikováno v:
Brain research. 637(1-2)
The distribution and density of NMDA receptors in spinal cord and motor cortex was compared in motor neuron disease (MND; 10 cases) and controls (8 cases) using [3H]MK-801 autoradiography. In the spinal ventral horn of MND cases, [3H]MK-801 binding w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8161c39894386ab82acd178344bfd57a
https://pubmed.ncbi.nlm.nih.gov/7514083
https://pubmed.ncbi.nlm.nih.gov/7514083
Publikováno v:
Brain research. 572(1-2)
The distribution of N-methyl-D-aspartate (NMDA) receptors in the normal human brainstem has been investigated using MK-801. Specific [3H]MK-801 binding showed a heterogeneous distribution, the greatest density of binding sites being found in the subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45d3890e4eb6234b3d417d9ff077194
https://pubmed.ncbi.nlm.nih.gov/1611523
https://pubmed.ncbi.nlm.nih.gov/1611523
Publikováno v:
Brain research. 539(1)
The distribution of NMDA receptors in the normal human spinal cord has been investigated using the non-competitive channel blocking agent MK-801. Specific [3H]MK-801 binding was present throughout the spinal grey matter at all segmental levels, the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56f5f4fca0e4a5b54caf85ffe01d211
https://pubmed.ncbi.nlm.nih.gov/1826627
https://pubmed.ncbi.nlm.nih.gov/1826627
Publikováno v:
Biochemical Society transactions. 18(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852610ad15baa5b1b9cf9e4d8b281fde
https://pubmed.ncbi.nlm.nih.gov/2177421
https://pubmed.ncbi.nlm.nih.gov/2177421