Zobrazeno 1 - 10
of 68
pro vyhledávání: '"John M. Barnard"'
Autor:
John M. Barnard, Geoffrey M. Downs
Publikováno v:
WIREs Computational Molecular Science. 1:727-741
The chemical structure information in patents remains difficult to access, partly because it is frequently expressed in the form of Markush structures, which can encompass enormous numbers of individual compounds. Early search systems were based on c
Autor:
John M. Barnard, P. Matthew Wright
Publikováno v:
World Patent Information. 31:97-103
Most large pharmaceutical and biotechnology companies now use Oracle RDBMS chemistry data cartridges to manage databases of individual molecules for chemical structure searching. These systems are often linked to processes for new drug discovery and
Publikováno v:
Tissue Antigens. 8:207-215
HLA typing was performed on 384 individuals of an isolated population of 1,500 people with a.familial aggregate of lymphoma and immunodeficiency cases. Eighty-five % of the total population were descendants of the founding couple. First cousin marria
Publikováno v:
Tissue Antigens. 17:265-268
We found HLA-DR5 to be present among 53% of 40 patients with goitrous autoimmune (Hashimoto's ) thyroiditis compared to 26% of 80 controls. No deviations from those expected in the incidences of HLA-A, B, C antigens were seen. In contrast HLA-DR3 was
Publikováno v:
Tissue Antigens. 13:342-348
One-hundred-and-forty-seven patients with autoimmune thyroiditis were studied with respect to HLA antigens as they related to various clinical features. HLA--B8 was found to be significantly increased among 59 patients with atrophic thyroiditis (57%
Publikováno v:
Tissue Antigens. 10:403-409
Five hundred and fourteen individuals from an isolated NewFoundland population have been typed and haplotyped for HLA and Factor B (Bf locus). The Bf gene frequencies were: S0.704, F0.226, F1 0.052 and S1 0.018. Tracing the haplotypes backwards on th
Autor:
Michael H. Charlton, Geoffrey M. Downs, Peter Willett, Roger Lahana, John M. Barnard, John D. Holliday, Florence Casset, Mark Ashton, Dominique Gorse
Publikováno v:
Quantitative Structure-Activity Relationships. 21:598-604
This paper reports a comparison of calculated molecular properties and of 2D fragment bit-strings when used for the selection of structurally diverse subsets of a file of 44295 compounds. MaxMin dissimilarity-based selection and k-means cluster-based
Publikováno v:
Virtual Screening for Bioactive Molecules
Publikováno v:
Journal of Chemical Information and Computer Sciences. 38:983-996
This paper reviews the use of similarity searching in chemical databases. It begins by introducing the concept of similarity searching, differentiating it from the more common substructure searching, and then discusses the current generation of fragm
Autor:
John M. Barnard, Geoff M. Downs
Publikováno v:
Perspectives in Drug Discovery and Design. :13-30
Though combinatorial libraries can be represented by enumerating the members of the library and using any of the commonly used computer representations for specific chemical structures, more compact forms are required for the processing of large ‘v